Results 31 to 40 of about 136,980 (341)

YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation [PDF]

, 2019
Yes-associated protein (YAP) is a transcriptional co-factor involved in many cell processes, including development, proliferation, stemness, differentiation, and tumorigenesis.
Amicone, Laura, Battistelli, Cecilia, Cicchini, Carla, Consalvi, Veronica, Cozzolino, Angela Maria, Marchetti, Alessandra, Noce, Valeria, Strippoli, Raffaele, Tripodi, Marco   +8 more
core   +1 more source

SRC-1 and GRIP1 Coactivate Transcription with Hepatocyte Nuclear Factor 4 [PDF]

Journal of Biological Chemistry, 1998
Hepatocyte nuclear factor-4 (HNF4), a member of the nuclear receptor superfamily, plays an important role in tissue-specific gene expression, including genes involved in hepatic glucose metabolism. In this study, we show that SRC-1 and GRIP1, which act as coactivators for various nuclear receptors, associate with HNF4 in vivo and enhance its ...
Jen-Chywan, Wang, John M, Stafford, Daryl K, Granner   +2 more
openaire   +2 more sources

The Hepatocyte nuclear factor-1 alpha (HNF1A) gene is associated with fatness and loin muscle area in the pig

Animal, 2010
The significance of hepatocyte nuclear factors (HNFs) in β-cell development and function has been generally recognized in humans, as evidenced by their associations with cases of maturity onset diabetes of the young (MODY).
B. Fan, Z.-Q. Du, M.F. Rothschild
doaj   +1 more source

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]

, 2018
The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello, AL Cattin, AM Cozzolino, C Battistelli, C Battistelli, C Battistelli, C Cicchini, C Cicchini, C Cicchini, C Padua Alves, Carla Cicchini, Cecilia Battistelli, Claudia Montaldo, DW Dodd, E Bolotin, F Garibaldi, F Parviz, Frank J. Gonzalez, Giovanna Sabarese, H Hagege, J Dekker, JA Bonzo, JL Rinn, K Kim, L Amicone, L Santangelo, Laura Santangelo, M Darsigny, MA Battle, Marco Tripodi, MC Tsai, MJ Milevskiy, N Skrypek, NL Lazarevich, R Kogo, RA Gupta, RE Hewitt, S Holwerda, S Satohisa, S Sekiya, SH Ahn, T Oshima, WD Garrison, Y Kamiyama, Y Nie, Y Qiao, Y Ren, YJ Geng, Z Chen, Z Yang, ZH Wu, ZQ Wu   +51 more
core   +1 more source

Hepatocyte Nuclear Factor 4  enhances the Hepatocyte Nuclear Factor 1 -mediated activation of transcription [PDF]

Nucleic Acids Research, 2004
Hepatocyte Nuclear Factor 1alpha (HNF1alpha) and Hepatocyte Nuclear Factor 4alpha (HNF4alpha) are two liver-enriched transcription factors coexpressed in specific tissues where they play a crucial role through their involvement in a complex cross-regulatory network.
openaire   +1 more source

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure [PDF]

, 2015
Hepatocellular carcinoma (HCC) is characterized by the accumulation of unfolded proteins in the endoplasmic reticulum (ER), which activates the unfolded protein response (UPR).
Ampe, Christophe, Bogaerts, Eliene, Descamps, Benedicte, Devisscher, Lindsey, Geerts, Anja, Govaere, O, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van den Bussche, A, Van Steenkiste, Christophe, Van Troys, Marleen, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vanhove, Christian, Verhelst, Xavier   +16 more
core   +6 more sources

Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter

Journal of Lipid Research, 2006
Hepatic lipase (HL) plays a key role in the metabolism of plasma lipoproteins, and its level of activity requires tight regulation, given the association of both low and high levels with atherosclerosis and coronary artery disease.
Laura E. Rufibach, Stephen A. Duncan, Michele Battle, Samir S. Deeb   +3 more
doaj   +1 more source

A renal hyperechogenicity study: From the phenotype to the genotype in the mutation of hepatocyte nuclear factor-1 beta gene

Anales de Pediatría (English Edition), 2019
Pilar Ribes Hernández, Adoración Granados Molina, Alicia García Pérez, Saoud Tahsin Swafiri, Esther Pérez Carbajo   +4 more
doaj   +2 more sources

TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases [PDF]

, 2019
The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process in the liver, where it contributes also to organ inflammation following several ...
Amicone, Laura, Battistelli, Cecilia, Bisceglia, Francesca, Marchetti, Alessandra, Montaldo, Claudia, Noce, Valeria, Strippoli, Raffaele, Tripodi, Marco, Zammataro, Agatino   +8 more
core   +1 more source

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. [PDF]

, 2017
The vascular endothelium is critical for induction of appropriate lineage differentiation in organogenesis. In this study, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla protein (MGP), causes ectopic hepatic ...
Blazquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guihard, Pierre J, Jumabay, Medet, Spencer, Melissa J, Tontonoz, Peter, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng   +9 more
core   +2 more sources