Results 81 to 90 of about 993,672 (387)

HDL functionality is dependent on hepatocyte stress defense factors Nrf1 and Nrf2

Frontiers in Physiology, 2023
High density lipoproteins (HDL) promote homeostasis and counteract stressful tissue damage that underlie cardiovascular and other diseases by mediating reverse cholesterol transport, reducing inflammation, and abrogating oxidative damage.
Michael J. Trites, Brynne M. Stebbings, Hiroyuki Aoki, Sadhna Phanse, May G. Akl, May G. Akl, Lei Li, Mohan Babu, Scott B. Widenmaier   +8 more
doaj   +1 more source

An optimal control approach for the treatment of hepatitis C patients [PDF]

arXiv, 2023
In this article, the feasibility of using optimal control theory will be studied to develop control theoretic methods for personalized treatment of HCV patients. The mathematical model for HCV progression includes compartments for healthy hepatocytes, infected hepatocytes, infectious virions and noninfectious virions.
arxiv  

Nuclear-size self-energy and vacuum-polarization corrections to the bound-electron g factor [PDF]

J. Phys. B 46, 245002 (2013), 2013
The finite nuclear-size effect on the leading bound-electron g factor and the one-loop QED corrections to the bound-electron g factor is investigated for the ground state of hydrogen-like ions. The calculation is performed to all orders in the nuclear binding strength parameter Z\alpha\ (where Z is the nuclear charge and \alpha\ is the fine structure ...
arxiv   +1 more source

Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1.

Proceedings of the National Academy of Sciences of the United States of America, 1990
The homeodomain-containing transcription factor hepatocyte nuclear factor 1 (HNF-1) most likely plays an essential role during liver organogenesis by transactivating a family of greater than 15 predominantly hepatic genes.
Calvin J. Kuo, Pamela B. Conley, C.-L. Hsieh, Uta Francke, Gerald R. Crabtreet   +4 more
semanticscholar   +1 more source

Variable phenotype in HNF1B mutations: extrarenal manifestations distinguish affected individuals from the population with congenital anomalies of the kidney and urinary tract [PDF]

, 2019
Background: Mutations in hepatocyte nuclear factor 1B (HNF1B) have been associated with congenital anomalies of the kidney and urinary tract (CAKUT) in humans. Diabetes and other less frequent anomalies have also been described.
Aguayo Calcena, Aníbal, Ariceta, Gema, Castaño González, Luis Antonio, García Castaño, Alejandro, Madariaga Domínguez, Leire, Martínez Salazar, Rosa   +5 more
core   +2 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Establishment of PLAFMCi005-A induced pluripotent stem cells derived from PBMC from a patient with renal cysts and diabetes syndrome

Stem Cell Research, 2021
Renal cysts and diabetes syndrome (RCAD) is caused by gene mutations in hepatocyte nuclear factor 1-β (HNF1B), but the underlying molecular mechanism is still unclear.
Shaoyuan Cui, Shunlai Shang, Shuwei Duan, Lingling Wu, Bo Fu, Xueyuan Bai, Qinggang Li, Xiangmei Chen   +7 more
doaj  

Letter to the Editor and Comments on: Intravital dynamic and correlative imaging reveals diffusion-dominated canalicular and flow-augmented ductular bile flux [PDF]

arXiv, 2020
Bile, the central metabolic product of the liver, is secreted by hepatocytes into bile canaliculi (BC), tubular subcellular structures of 0.5-2 $\mu$m diameter which are formed by the apical membranes of juxtaposed hepatocytes. BC interconnect to build a highly ramified 3D network that collects and transports bile towards larger interlobular bile ducts
arxiv  

Nuclear-polarization correction to the bound-electron g factor in heavy hydrogenlike ions [PDF]

, 2002
The influence of nuclear polarization on the bound-electron $g$ factor in heavy hydrogenlike ions is investigated. Numerical calculations are performed for the K- and L-shell electrons taking into account the dominant virtual nuclear excitations. This determines the ultimate limit for tests of QED utilizing measurements of the bound-electron $g$ factor
arxiv   +1 more source

Different response to epidermal growth factor of hepatocytes in cultures isolated from male or female rat liver. Inhibitor effect of estrogen on binding and mitogenic effect of epidermal growth factor [PDF]

, 1987
Deoxyribonucleic acid (DNA) synthesis in hepatocytes isolated from the livers of male and female rats has been compared in monolayer culture. Plating efficiency, DNA and protein content, viability, and morphologic appearance were the same in cultures ...
Coetzee, M, Francavilla, A, Kam, I, Ove, P, Pellici, R, Polimeno, L, Sciascia, C, Starzl, TE, Todo, S   +8 more
core   +1 more source