Results 11 to 20 of about 127,242 (210)

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources

Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha.

PLoS ONE, 2009
The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear
Lie Li, Claudia E Oropeza, Bruno Sainz, Susan L Uprichard, Frank J Gonzalez, Alan McLachlan   +5 more
doaj   +1 more source

Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B–Lamin B1 Interaction in Alcoholic Fatty Liver Disease

Frontiers in Pharmacology, 2022
Recent studies indicated that hepatocyte senescence plays an important role in the development of alcoholic fatty liver disease (AFLD), suggesting that inhibition of hepatocyte senescence might be a potential strategy for AFLD treatment.
Xiaoyu Qi, Shuguo Zheng, Mingyue Ma, Naqi Lian, Hongting Wang, Lerong Chen, Anping Song, Chunfeng Lu, Shizhong Zheng, Huanhuan Jin   +9 more
doaj   +1 more source

YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation [PDF]

, 2019
Yes-associated protein (YAP) is a transcriptional co-factor involved in many cell processes, including development, proliferation, stemness, differentiation, and tumorigenesis.
Amicone, Laura, Battistelli, Cecilia, Cicchini, Carla, Consalvi, Veronica, Cozzolino, Angela Maria, Marchetti, Alessandra, Noce, Valeria, Strippoli, Raffaele, Tripodi, Marco   +8 more
core   +1 more source

The Hepatocyte nuclear factor-1 alpha (HNF1A) gene is associated with fatness and loin muscle area in the pig

Animal, 2010
The significance of hepatocyte nuclear factors (HNFs) in β-cell development and function has been generally recognized in humans, as evidenced by their associations with cases of maturity onset diabetes of the young (MODY).
B. Fan, Z.-Q. Du, M.F. Rothschild
doaj   +1 more source

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]

, 2018
The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello, AL Cattin, AM Cozzolino, C Battistelli, C Battistelli, C Battistelli, C Cicchini, C Cicchini, C Cicchini, C Padua Alves, Carla Cicchini, Cecilia Battistelli, Claudia Montaldo, DW Dodd, E Bolotin, F Garibaldi, F Parviz, Frank J. Gonzalez, Giovanna Sabarese, H Hagege, J Dekker, JA Bonzo, JL Rinn, K Kim, L Amicone, L Santangelo, Laura Santangelo, M Darsigny, MA Battle, Marco Tripodi, MC Tsai, MJ Milevskiy, N Skrypek, NL Lazarevich, R Kogo, RA Gupta, RE Hewitt, S Holwerda, S Satohisa, S Sekiya, SH Ahn, T Oshima, WD Garrison, Y Kamiyama, Y Nie, Y Qiao, Y Ren, YJ Geng, Z Chen, Z Yang, ZH Wu, ZQ Wu   +51 more
core   +1 more source

Generation of a PXR reporter human induced pluripotent stem cell line (PXR-mCherry hiPSC) using the CRISPR/Cas9 system

Stem Cell Research, 2018
Pregnane X receptor (PXR) is a key nuclear receptor that mediates drug metabolism and stimulates hepatocyte proliferation. However, the lack of PXR expression in human pluripotent stem cell-derived hepatocytes limits their application for drug screening ...
Hyemin Kim, Ji-Woo Kim, So-Jin Kim, Young-Jun Choi, Dae-Sung Kim, Han-Jin Park   +5 more
doaj   +1 more source

Galectin-1 is essential for efficient liver regeneration following hepatectomy [PDF]

, 2016
Galectin-1 (Gal1) is a known immune/inflammatory regulator which actsboth extracellularly and intracellularly, modulating innate and adaptive immuneresponses. Here, we explored the role of Gal1 in liver regeneration using 70% partial hepatectomy (PHx) of
Cerliani, Juan Pablo, Ella, Ezra, Galun, Eithan, Goldenberg, Daniel S., Mizrahi, Lina, Pappo, Orit, Potikha, Tamara, Rabinovich, Gabriel Adrián   +7 more
core   +1 more source

Cell proliferation and oncogene expression after bile duct ligation in the rat: Evidence of a specific growth effect on bile duct cells [PDF]

, 1995
The proliferative response of the rat liver was measured after temporary or permanent total biliary obstruction (BDO) and in different regions after selective ligation of the lobar ducts draining the right 60% of the hepatic mass.
Azzarone, A, Bouzahzah, B, Carr, B, Francavilla, A, Panella, C, Polimeno, L, Starzl, TE, Subbotin, V, Zeng, QH   +8 more
core   +1 more source

The Dynamic Chromatin Architecture of the Regenerating LiverSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: The adult liver is the main detoxification organ and routinely is exposed to environmental insults but retains the ability to restore its mass and function upon tissue damage.
Amber W. Wang, Yue J. Wang, Adam M. Zahm, Ashleigh R. Morgan, Kirk J. Wangensteen, Klaus H. Kaestner   +5 more
doaj   +1 more source