Results 31 to 40 of about 127,242 (210)

Development and characterization of a new human hepatic cell line [PDF]

, 2015
The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert, De Craene, Bram, De Kock, Joey, Ramboer, Eva, Rogiers, Vera, Vanhaecke, Tamara, Vinken, Mathieu   +6 more
core   +3 more sources

Hepatocyte-like cells derived from human induced pluripotent stem cells using small molecules: implications of a transcriptomic study

Stem Cell Research & Therapy, 2020
Background Hepatocyte-like cells (HLCs) derived from human induced pluripotent stem cells (iPSCs) hold great promise in toxicological applications as well as in regenerative medicine.
Xiugong Gao, Rong Li, Patrick Cahan, Yang Zhao, Jeffrey J. Yourick, Robert L. Sprando   +5 more
doaj   +1 more source

Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors

Journal of Lipid Research, 1998
The gene encoding cholesterol 7α-hydroxylase (CYP7A), the rate-limiting enzyme in bile acid synthesis, is transcriptionally regulated by bile acids and hormones. Previously, we have identified two bile acid response elements (BARE) in the promoter of the
Maurizio Crestani, Azita Sadeghpour, Diane Stroup, Giovanni Galli, John Y.L. Chiang   +4 more
doaj   +1 more source

Core promoter: A critical region where the hepatitis B virus makes decisions [PDF]

, 2014
The core promoter (CP) of the viral genome plays an important role for hepatitis B virus (HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic (pg) RNAs.
Quarleri, Jorge Fabian
core   +1 more source

Impact of Nucleotide Mutations at the HNF3- and HNF4-Binding Sites in Enhancer 1 on Viral Replication in Patients with Chronic Hepatitis B Virus Infection

Gut and Liver, 2013
Background/AimsThe hepatitis B virus (HBV) genome contains binding sites for hepatocyte nuclear factors (HNF) 3 and 4 in the core domain of enhancer 1 (Enh1), and mutations in this domain have a strong impact on virus replication.
doaj   +1 more source

Multiple roles and regulatory mechanisms of the transcription factor HNF4 in the intestine

Frontiers in Endocrinology, 2023
Hepatocyte nuclear factor 4-alpha (HNF4α) drives a complex array of transcriptional programs across multiple organs. Beyond its previously documented function in the liver, HNF4α has crucial roles in the kidney, intestine, and pancreas. In the intestine,
Kiranmayi Vemuri, Kiranmayi Vemuri, Sarah H. Radi, Sarah H. Radi, Frances M. Sladek, Michael P. Verzi, Michael P. Verzi   +6 more
doaj   +1 more source

Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells. [PDF]

, 2015
Sirtuin (Sirt) 1 and Sirt 3 are nicotinamide adenine dinucleotide ((+))-dependent protein deacetylases that are important to a number of mitochondrial-related functions; thus, identification of sirtuin activators is important. Herein, we hypothesize that
Arguelles, Andrix, Bedi, Yudhishtar Singh, Chau, Jason, Choudhury, Mahua, Meruvu, Sunitha, Rucker, Robert, Zhang, Jian   +6 more
core   +1 more source

Mutational landscapes of HNF MODY gene products display a wide distribution with functional implications

Endocrine Connections
Hepatocyte nuclear factors (HNFs) play an essential role in the development and function of vital organs such as the liver, kidney, intestine, and pancreas by regulating the expression of multiple genes involved in organ development, nutrient transport ...
Young-In Chi, Raul Urrutia
doaj   +1 more source

Hormonal Contribution to Liver Regeneration

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2020
An understanding of the molecular basis of liver regeneration will open new horizons for the development of novel therapies for chronic liver failure. Such therapies would solve the drawbacks associated with liver transplant, including the shortage of ...
Anan A. Abu Rmilah, MD, Wei Zhou, MD, PhD, Scott L. Nyberg, MD, PhD   +2 more
doaj   +1 more source

Effect on the canine Eck fistula liver of intraportal TGF‐β alone or with hepatic growth factors [PDF]

, 1992
Transforming growth factor‐β canceled the hepatocyte proliferation caused by transforming growth factor‐α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast,
Alessandro Azzarone, Antonio Francavilla, Braun, Carlo Scotti-Fogueni, Carr, Fausto, Francavilla, Francavilla, Goustin, Gruppuso, Guiseppe Carrieri, Houck, Kendrick Porter, Mazzaferro, Mead, Michalopoulos, Michalopoulos, Qia-Hua Zeng, Richman, Roberts, Short, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Thomas E. Starzl, Umberto Cillo   +28 more
core   +1 more source