Results 41 to 50 of about 127,242 (210)

HDL functionality is dependent on hepatocyte stress defense factors Nrf1 and Nrf2

Frontiers in Physiology, 2023
High density lipoproteins (HDL) promote homeostasis and counteract stressful tissue damage that underlie cardiovascular and other diseases by mediating reverse cholesterol transport, reducing inflammation, and abrogating oxidative damage.
Michael J. Trites, Brynne M. Stebbings, Hiroyuki Aoki, Sadhna Phanse, May G. Akl, May G. Akl, Lei Li, Mohan Babu, Scott B. Widenmaier   +8 more
doaj   +1 more source

JNK signalling in cancer: In need of new, smarter therapeutic targets [PDF]

, 2013
Copyright © 2013 The British Pharmacological Society. This is the accepted version of the following article: Bubici, C. and Papa, S. (2014), JNK signalling in cancer: in need of new, smarter therapeutic targets.
Adams, Ahmed, Anbalagan, Annunziata, Antonyak, Bain, Barbarulo, Barr, Behrens, Bennett, Bharti, Bogoyevitch, Bogoyevitch, Borsello, Bost, Carboni, Cazanave, Cellurale, Cellurale, Cellurale, Chang, Chang, Chauhan, Chen, Chen, Chen, Chen-Deutsch, Cho, Choi, Chromik, Cilloni, Cripe, Cui, Cui, Das, Davis, Deininger, Dérijard, Eferl, Estey, Farazi, Ferrandi, Finegan, Fuchs, Gaillard, Gao, Gao, Gilmore, Goenka, Graff, Gururajan, Hagiwara, He, Heo, Hess, Hideshima, Hideshima, Hideshima, Hirosumi, Ho, Huang, Hui, Hunot, Jaeschke, Jagtap, Jemal, Johnson, Kamenecka, Kaneto, Kaoud, Ke, Keats, Kersting, Kuan, Kuperwasser, Li, Llovet, Lloyd, LoGrasso, Luedde, Maclean, Maeda, Mamay, Manning, Manning, Min, Mucha, Murati, Nagata, Nateri, Ngoei, Ngoei, Nitta, Oleinik, Owens, Papa, Papa, Plantevin Krenitsky, Qiu, Raitano, Reinecke, Ricard, Rodrigues, Ronaldson, Roy, Sabapathy, Sakurai, Schramek, Seki, She, Siddiqui, Smeal, Srivastava, Stebbins, Su, Su, Szczepankiewicz, Takahashi, Tong, Tournier, Tsuiki, Waetzig, Wagner, Wang, Wang, Webster, Whitmarsh, Whitmarsh, Yamamoto, Yan, Yang, Yao, Yoon, Yoshida, Zhang, Zhang, Zhang, Zhang   +137 more
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Differential spatial distribution of HNF4α isoforms during dysplastic progression of intraductal papillary mucinous neoplasms of the pancreas

Scientific Reports, 2023
Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions.
Jahg Wong, Vincent Q. Trinh, Nidhi Jyotsana, Jumanah F. Baig, Frank Revetta, Chanjuan Shi, Anna L. Means, Kathleen E. DelGiorno, Marcus Tan   +8 more
doaj   +1 more source

CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α) regulate expression of the human fructose-1,6-bisphosphatase 1 (FBP1) gene in human hepatocellular carcinoma HepG2 cells. [PDF]

PLoS ONE, 2018
Fructose-1,6-bisphosphatase (FBP1) plays an essential role in gluconeogenesis. Here we report that the human FBP1 gene is regulated by two liver-enriched transcription factors, CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor 4α ...
Siriluck Wattanavanitchakorn, Pinnara Rojvirat, Tanit Chavalit, Michael J MacDonald, Sarawut Jitrapakdee   +4 more
doaj   +1 more source

Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcription factors [PDF]

, 1993
Extinction is defined as the loss of cell type-specific gene expression that occurs in somatic cell hybrids derived by fusion of cells with dissimilar phenotypes.
Boshart, Michael, Nitsch, Doris, Schütz, Günther   +2 more
core   +1 more source

Hepatic Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) regulates metabolism in mice. [PDF]

PLoS ONE, 2017
Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) and its partners hypoxia-inducible factors (HIF)-1α and HIF-2α are candidate factors for the well-known link between the liver, metabolic dysfunction and elevation in circulating lipids and glucose ...
Christopher H Scott, Kuan-Minn Cha, Jason Ngai, Changtao Jiang, Kim Cheng, Rebecca A Stokes, Kenneth W K Ho, Jacob George, Frank J Gonzalez, Jenny E Gunton   +9 more
doaj   +1 more source

Growth Hormone Mediates Its Protective Effect in Hepatic Apoptosis through Hnf6. [PDF]

PLoS ONE, 2016
Growth hormone (GH) not only supports hepatic metabolism but also protects against hepatocyte cell death. Hnf6 (or Oc1) belonging to the Onecut family of hepatocyte transcription factors known to regulate differentiated hepatic function, is a GH ...
Kewei Wang, Minhua Wang, Maureen Gannon, AiXuan Holterman   +3 more
doaj   +1 more source

Searching for "monogenic diabetes" in dogs using a candidate gene approach [PDF]

, 2014
BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and ...
Catchpole, B, Holder, A L, Kennedy, L J, Massey, J, Ollier, W E R, Rothwell, S, Scholey, R, Short, A D   +7 more
core   +3 more sources

The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition [PDF]

, 2016
The transcription factor Snail is a master regulator of cellular identity and epithelial-to-mesenchymal transition (EMT) directly repressing a broad repertoire of epithelial genes.
A Kuzmichev, A Tramontano, AM Khalil, C Battistelli, C Battistelli, C Chu, C Cicchini, C Cicchini, C Cicchini, C Cicchini, C Cicchini, C Cifuentes-Rojas, C Davidovich, CA McHugh, CL Tien, E Bolotin, F Garibaldi, F J Gonzalez, G Deb, G Grassi, H Peinado, H Peinado, J Chen, J Yang, J Zhao, JA Simon, JL Rinn, JP Thiery, KD Nolan, L Amicone, L Amicone, L Grassi, L Li, L Santangelo, L Santangelo, M Colletti, M Courel, M Kretz, M Rodriguez, M Tripodi, M Yu, MA Nieto, MA Perez-Moreno, MC Tsai, OG McDonald, P Arnold, P Wongtrakoongate, Q Cao, R Cao, R Kogo, RA Gupta, RY Huang, S Fujii, S Javaid, S Kaneko, S Lamouille, TD Schmittgen, V de Nonno, Y Chen, Y Lin, Y Nie, Y Yonemitsu, YJ Geng, Z Hou, Z Yang, ZT Tong   +65 more
core   +2 more sources

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection [PDF]

, 2020
Bovine African Trypanosomosis is an infectious parasitic disease affecting livestock productivity and thereby impairing the economic development of Sub-Saharan Africa. The most important trypanosome species implicated is T.
Brys, Lea, De Baetselier, Patrick, De Trez, Carl, Korf, Hannelie, Magez, Stefan, Stijlemans, Benoit, Van Ginderachter, Jo A   +6 more
core   +1 more source