Results 91 to 100 of about 77,264 (275)

Interpretable machine learning enables early and accurate detection of drug‐induced liver injury: A multicenter study with real‐world clinical translation

Interdisciplinary Medicine, EarlyView.
This study develops an interpretable gradient‐boosting model that accurately identifies drug‐induced liver injury (DILI) using routine laboratory data. The model explains key clinical features through SHapley Additive exPlanations analysis and detects DILI earlier than expert evaluation, offering a transparent and practical tool for precision ...
Jingyi Ling, Shian Zhang, Jun Lin, Zhengju Xu, Runcheng Xu, Qian Lv, Kaixiang Zhang, Sheng Liu, Jie Guo, Cheng Hua, Yin Jia, Xiaoyu Xu, Kun Qian, Shanrong Liu   +13 more
wiley   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Hepatoprotective effect of Chichorium intybus L. on liver toxicity in rat

Journal of Medicinal Plants, 2006
Background: Plant phenolic compounds such as flavonoids have important role in treatment of many diseases. Also some of them have potent hepatoprotective effects.
H Madani, S Asgary, GH Naderi, M Talebolhoseini   +3 more
doaj  

Aronia melanocarpa (Michaux) Elliot Fruit Juice Attenuates Acetaminophen-induced Hepatotoxicity on Larval Zebrafish Model

Journal of Agricultural Sciences
Aronia melanocarpa (Michaux) Elliot (chokeberry) is a natural medicinal plant with a rich content of phenolic compounds such as procyanidins, anthocyanins, and phenolic acids.
Gülçin Çakan Akdoğan, Çiğdem Bilgi
doaj   +1 more source

Hepatoprotective and Renoprotective Properties of Lovastatin-Loaded Ginger and Garlic Oil Nanoemulsomes: Insights into Serum Biological Parameters

Medicina, 2019
Background and Objectives: Dyslipidemia is gaining much attention among healthcare professionals because of its high association with the malfunctioning of a number of normal physiological and metabolic processes in the body.
Syed Ali Faran, Sajid Asghar, Syed Haroon Khalid, Ikram Ullah Khan, Muhammad Asif, Ikrima Khalid, Umar Farooq Gohar, Tanveer Hussain   +7 more
doaj   +1 more source

Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature [PDF]

, 2017
The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper.
Busardò, F. P, DI LUCA, Natale Mario, Gentili, S, Graziano, Silvia, Mannocchi, Giulio, Marinelli, Enrico, Pantano, Flaminia   +6 more
core  

Integrated characterization of Greek fennel genotypes through morpho‐agronomical characteristics, yield components and phytochemical compounds

JSFA reports, Volume 5, Issue 3, Page 91-103, March 2025.
Abstract Background Fennel (Foeniculum vulgare Mill.) is a widely cultivated vegetable and aromatic‐medicinal plant. In this research, field studies assessed 12 fennel genotypes of diverse origin, comprising 10 Greek accessions and two European commercial varieties, focusing on their morpho‐agronomical traits, phenolic compounds and antioxidant ...
Kalliopi I. Kadoglidou, Christos Maliachovas, Parthenopi Ralli, Maria Irakli, Nektaria Tsivelika, Athanasios G. Mavromatis, Paschalina Chatzopoulou   +6 more
wiley   +1 more source

Hepatoprotective effect of Silybum marianum (L.) Gaertn. and Glycyrrhiza glabra L. in the rats

Journal of Medicinal Plants, 2005
Bachground: One of the major role of liver is metabolism of xenobiotics and detoxification. But sometimes, during metabolism of xenobiotics produce active and more toxic agents which cause liver damege and disease.
S Asgary, H Madani, GH Naderi, SH Toori, M Taleb –Alhoseini   +4 more
doaj  

Complementary effect of Capparis spinosa L. and silymarin with/without praziquantel on mice experimentally infected with Schistosoma mansoni

Helminthologia, 2018
Schistosomiasis remains to be the most common fibrotic disease resulting from inflammation and deposition of scar tissue around trapped parasitic eggs in the liver. Though chemotherapy eradicates matured worms efficiently and prevents the accumulation of
El-Hawary S. S., Taha K. F., Kirillos F. N., Dahab A. A., El-Mahis A. A., El-Sayed S. H.   +5 more
doaj   +1 more source

Hepatitis C: From inflammatory pathogenesis to anti-inflammatory/hepatoprotective therapy [PDF]

, 2018
Hepatitis C virus (HCV) infection commonly causes progressive liver diseases that deteriorate from chronic inflammation to fibrosis, cirrhosis and even to hepatocellular carcinoma.
Huang, Meng-Hao, Jiang, Jian-Dong, Li, Hu, Peng, Zong-Gen   +3 more
core   +2 more sources