Results 111 to 120 of about 77,264 (275)

Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study [PDF]

, 2018
Excessive drinking can lead to the development of immune dysfunction. Our aim is to investigate the effect of alcohol on immune activation from circulating peripheral blood monocytes in excessive drinkers (EDs).
Blum, Janice S., Liangpunsakul, Suthat, Linton, Tobyn, Mangiacarne, Darrin, Walline, Crystal C.   +4 more
core   +1 more source

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

Melatonin Promotes Improvement in Serum Lipid Levels and Liver Histopathology in Hyperlipidemic Rats

Lipids, EarlyView.
ABSTRACT Hyperlipidemia or dyslipidemia is the term used for the increase in lipid levels in blood plasma, usually occurring due to a high‐fat diet associated with a sedentary lifestyle. The increase in lipid levels can cause fatty infiltration in the liver known as hepatic steatosis, which can lead to inflammation, fibrosis, and necrosis consecutively.
Ana Cláudia Carvalho de Sousa, Jaiurte Gomes Martins da Silva, Érique Ricardo Alves, Laís Caroline da Silva Santos, Bruno José do Nascimento, Marcelle Mariana Sales de França, Vanessa Bischoff Medina, Ismaela Maria Ferreira de Melo, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira   +9 more
wiley   +1 more source

A review for discovering hepatoprotective herbal drugs with least side effects on kidney [PDF]

, 2017
The liver is a vital organ which plays a major role in the metabolism and excretion of xenobiotics from the body, and liver disease is a worldwide health problem.
Asadi-Samani, Majid., Heidari-Soureshjani, Saeid., Luther, Tahra., Raeisi, Roya., Shirani, Majid.   +4 more
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Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Assessing the Antioxidant, Hepatoprotective, and Iron-Chelating Potential of Perilla frutescens Seed

Biomedicines
Background/Objectives: Iron overload is a serious condition that can increase the production of reactive oxygen species (ROS), leading to oxidative tissue damage and organ dysfunction.
Sirichatnach Pakdeepromma, Komsak Pintha, Payungsak Tantipaiboonwong, Chonthida Thephinlap, Maitree Suttajit, Sawaruj Kaowinn, Napapan Kangwan, Wanwisa Suwannaloet, Kanjana Pangjit   +8 more
doaj   +1 more source

Review of plants with hepatoprotective activity evaluated in Mexico [PDF]

, 2014
Liver diseases represent a major health problem around the world. in Mexico these are the 5th leading cause of death in the economically active population.
Cordero Pérez, Paula, Muñoz Espinosa, Linda Elsa, Pérez Meseguer, Jonathan, Salazar Aranda, Ricardo, Torres González, Liliana, Waksman de Torres, Noemí   +5 more
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Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats

Current Issues in Pharmacy and Medical Sciences, 2019
This study evaluated the hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats. The extract of P.
Onoja Samuel O., Daniel-Igwe Gloria, Ejiofor Emmanuel, Mbakwe Christiana C., Okeke Ugochuhwu S., Ezeja Maxwell I., Omeh Yusuf N., Asuzu Isaac U.   +7 more
doaj   +1 more source

The Effect of Oscimum Sanctum to the Thrombocytes Number on Mice [PDF]

, 2016
Oscimum sanctum is herbal that was spread widely in Indonesia. Oscimum sanctum contains abundant of substances. One of the functions on Oscimum sanctum was anti-thrombocytes effect. This effect is associated with platelet function as a mechanical plug in
Astuti, Y. (Yoni), Wijayanti, R. (Rum)
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