Results 81 to 90 of about 137,616 (341)

Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia

Advanced Science, EarlyView.
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji, Yongli Ye, Jiadi Sun, Lina Sheng, Jinyou Li, Jin Yang, Bing Wu, Yuting Wang, Xingxing Gao, Liang Luo, Jianfeng Ping, Yinzhi Zhang, Xiulan Sun   +12 more
wiley   +1 more source

Oral Celastrol Micelles Forming High‐Density Lipoprotein Corona Targeting Hepatocytes for MASLD Treatment

Advanced Science, EarlyView.
Upon oral administration, OPDEA‐PCL/CEL micelles passed through the stomach acid intact, then quickly penetrated the intestinal mucus and transported into circulation, where they captured HDL to form a protein corona and target hepatocyte SR‐B1 receptors, inducing endocytosis.
Chang Xu, Haoru Zhu, Kai Wang, Haitao Hu, Xuyong Wei, Dongdong Xu, Jing Zhang, Yanpeng Liu, Jun Chen, Youqing Shen, Nasha Qiu, Xiao Xu   +11 more
wiley   +1 more source

HAART and liver: is it safe?

Journal of Infection in Developing Countries, 2014
Introduction: Liver disease caused by hepatitis C virus (HCV) is a major cause of morbidity in HIV patients. This study investigates the possibility that chronic HCV increases the risk of hepatotoxicity after highly active antiretroviral therapy (HAART ...
Vicente Sperb Antonello, Dimas Alexandre Kliemann, Breno Rigel Santos, Cristiane Valle Tovo   +3 more
doaj   +1 more source

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Archives of Toxicology, 2013
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes ...
P. Godoy, N. Hewitt, U. Albrecht, M. Andersen, N. Ansari, S. Bhattacharya, J. Bode, J. Bolleyn, C. Borner, J. Böttger, A. Braeuning, R. Budinsky, B. Burkhardt, N. Cameron, G. Camussi, C. Cho, Yun-Jaie Choi, J. Craig Rowlands, U. Dahmen, G. Damm, O. Dirsch, M. Donato, Jian Dong, S. Dooley, D. Drasdo, R. Eakins, Karine Ferreira, V. Fonsato, J. Fraczek, R. Gebhardt, Andrew Gibson, M. Glanemann, C. Goldring, M. Gómez‐Lechón, G. Groothuis, L. Gustavsson, C. Guyot, D. Hallifax, S. Hammad, Adam S. Hayward, D. Häussinger, C. Hellerbrand, P. Hewitt, S. Hoehme, H. Holzhütter, J. Houston, Jens Hrach, Kiyomi Ito, H. Jaeschke, V. Keitel, J. Kelm, B. Kevin Park, C. Kordes, G. Kullak-Ublick, E. LeCluyse, Peng Lu, Jennifer Luebke‐Wheeler, Anna Lutz, Daniel J. Maltman, M. Matz-Soja, P. McMullen, I. Merfort, S. Messner, C. Meyer, J. Mwinyi, D. Naisbitt, A. Nussler, P. Olinga, F. Pampaloni, J. Pi, L. Pluta, S. Przyborski, A. Ramachandran, V. Rogiers, C. Rowe, C. Schelcher, Kathrin Schmich, M. Schwarz, Bijay Singh, E. Stelzer, B. Stieger, Regina M. Stöber, Y. Sugiyama, C. Tetta, W. Thasler, T. Vanhaecke, M. Vinken, T. Weiss, Agata Widera, C. Woods, J. Xu, Kathy M. Yarborough, J. Hengstler   +92 more
semanticscholar   +1 more source

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source

Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIV/HCV Coinfected Patients

AIDS Research and Treatment, 2010
Introduction. Hepatotoxicity is a concern in HIV/hepatitis C virus (HCV) coinfected patients due to their underlying liver disease. This study assessed the incidence of hepatotoxicity in HIV/HCV co-infected patients in two outpatient infectious diseases ...
Emily L. Heil, Mary L. Townsend, Kenneth Shipp, Amy Clarke, Melissa D. Johnson   +4 more
doaj   +1 more source

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

Nanographene Oxide Attenuates Acute GVHD by Modulating Macrophage Polarization in a Xenogeneic Mouse Model

Advanced Science, EarlyView.
Nanographene oxide (NGO) attenuates graft‐versus‐host disease (GVHD) severity by inhibiting STAT1‐mediated M1 macrophage polarization and suppressing T‐cell activation. NGO‐primed macrophages (NGO‐Mac) further enhance regulatory T‐cell induction via IL‐10. Both NGO and NGO‐Mac therapies mitigate inflammation and immune pathology, offering cell‐free and
Aaron Yu, Hyun Sung Park, Dong‐Hoon Chae, Jae Han Park, Jiyoung Heo, Keonwoo Cho, Jiho Kim, Hyewon Lee, Sueyeon Jee, Chanwoo Kim, Soon Won Choi, Jaechul Ryu, Eun‐Hye Hur, Yunsuk Choi, Eun‐Ji Choi, Mi‐Kyung Oh, Hwa‐Yong Lee, Je‐Hwan Lee, Kyung‐Rok Yu   +18 more
wiley   +1 more source

Reported hepatotoxicity and hepatotoxicity guidance in the product information of protein kinase inhibitors in oncology registered at the European Medicines Agency

Pharmacology Research & Perspectives, 2023
Protein kinase inhibitors (PKIs) used in oncology can induce severe and even fatal hepatotoxicity. Several PKIs are registered within a certain class to target a specific kinase.
Marc Maliepaard, Yoran S. Faber, Mark T. J. vanBussel   +2 more
doaj   +1 more source

Deoxynivalenol Exposure Leads to Abnormal Renal Tubular Autophagy Flow

Advanced Science, EarlyView.
DON exposure disrupts the initiation of renal autophagy by inhibiting the formation of autophagosomes, thereby impairing mitochondrial degradation. Damaged mitochondria increase oxidative stress, reduce ferroptosis resistance, and cause lysosomal Fe2⁺ accumulation, further disrupting autophagy.
Hao Chen, Xintong Zhou, Jun Ma
wiley   +1 more source