Results 81 to 90 of about 146,077 (348)
Pharmacology Research & Perspectives, 2023 Protein kinase inhibitors (PKIs) used in oncology can induce severe and even fatal hepatotoxicity. Several PKIs are registered within a certain class to target a specific kinase.
Marc Maliepaard +2 more
doaj +1 more source
Saikosaponins with similar structures but different mechanisms lead to combined hepatotoxicity [PDF]
arXiv, 2018 Radix Bupleuri is a hepatoprotective traditional Chinese medicine (TCM) used for thousands of years in clinical, which was reported to be linked with liver damage. Previous studies have revealed that saikosaponins are the major types of components that contribute to the hepatotoxicity of Radix Bupleuri. However the underlying molecular mechanism is far
arxiv
British Journal of Clinical Pharmacology, EarlyView.Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy +4 more
wiley +1 more source
Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIV/HCV Coinfected Patients
AIDS Research and Treatment, 2010 Introduction. Hepatotoxicity is a concern in HIV/hepatitis C virus (HCV) coinfected patients due to their underlying liver disease. This study assessed the incidence of hepatotoxicity in HIV/HCV co-infected patients in two outpatient infectious diseases ...
Emily L. Heil +4 more
doaj +1 more source
Journal of Infection in Developing Countries, 2014 Introduction: Liver disease caused by hepatitis C virus (HCV) is a major cause of morbidity in HIV patients. This study investigates the possibility that chronic HCV increases the risk of hepatotoxicity after highly active antiretroviral therapy (HAART ...
Vicente Sperb Antonello +3 more
doaj +1 more source
Recent advances of nanomaterials in imaging liver fibrosis
BMEMat, EarlyView.Schematic summary on the latest strategies of liver fibrosis imaging based on various nanomaterials. Abstract Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors. It is characterized by the abnormal proliferation and activation of hepatic stellate cells and excessive deposition of extracellular matrix ...
Jin Cui +11 more
wiley +1 more source
IL-1RN and IL-1β Polymorphism and ARV-Associated Hepatotoxicity
Mediators of Inflammation, 2018 The severity of hepatic injury depends upon cytokines. Previous studies associated IL-1RN allele 2 with IL-1β production. Hence, we examined the association of IL-1 RN and IL-1β polymorphisms with ARV-associated hepatotoxicity. Genotyping of IL-1RN (VNTR)
HariOm Singh +4 more
doaj +1 more source
Three-dimensional cell culture model for hepatocytes opens a new avenue of real world research on liver [PDF]
arXiv, 2019 3-demensional (3D) culture model is a valuable in vitro tool to study liver biology, metabolism, organogenesis, tissue morphology, drug discovery and cell-based assays. Compelling evidence suggests that cells cultured in 3D model exhibit superior liver-specific functions over the conventional 2-dimentional (2D) culture in evaluating hepatobiliary drug ...
arxiv
Evaluation of Polar Substituted Schiff Bases and 1,2,3‐Triazole Hybrids as Anticancer Agents
Chemistry &Biodiversity, EarlyView.ABSTRACT Polar substituted Schiff bases and 1,2,3‐triazole hybrids (2–6) were successfully synthesized by Schiff base condensation reaction between the previously synthesized triazole 1 and series of polar substituted amines. The chemical structures of the hybrids were confirmed using spectroscopies (NMR and FTIR), CHN elemental analysis and single ...
Yonas Belay +5 more
wiley +1 more source
Discriminating Different Classes of Toxicants by Transcript Profiling [PDF]
, 2004 Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing.
Albertini, Silvio +6 more
core +2 more sources