Results 151 to 160 of about 4,105 (286)

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, EarlyView.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

Drug-Induced Liver Injury Associated With an Over-The-Counter Supplement. [PDF]

ACG Case Rep J
Pearose D, Perez Montoya E, Gutierrez J, Cuenca J, Singleterry R, Qudratulla A, Saikumar A, Housini M.   +7 more
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models. [PDF]

Toxicol Sci
Jaeschke H, Ramachandran A.
europepmc   +1 more source

Analgesic use, safety and pharmacokinetics of acetaminophen in equids: A structured scoping review

Equine Veterinary Journal, EarlyView.
Abstract Background Despite its frequent use in equine clinical practice, scientific data on the use of acetaminophen in horses remain limited. Objective To map and critically appraise the available evidence on the analgesic use, safety and pharmacokinetics of acetaminophen in horses. Study Design Structured scoping review.
Francisco Medina‐Bautista, Juan Manuel Serrano‐Rodríguez, María del Mar Granados   +2 more
wiley   +1 more source

The E3 Ligase RNF8 Promotes Ubiquitination and Degradation of ChREBPα During Liver Stress Response. [PDF]

FASEB J
Zhao Y, Wang S, Zhang J, Cooke S, Zhang G, Zhao Z, Oh J, Tong X, Yin L.   +8 more
europepmc   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Hepatocyte Transforming Growth Factor-β-Oxysterol-Binding Protein-Related Protein 3 Signaling Axis Promotes Hepatic Stellate Cell Activation and Liver Fibrogenesis in Mice. [PDF]

Cell Mol Gastroenterol Hepatol
Gao J, Zhang G, Wang S, Zhao Y, Zhao Q, Hu Z, Zhang J, Cooke S, Tong X, Yin L.   +9 more
europepmc   +1 more source

Nodularia spumigena, a toxic cyanobacterium forming blooms in the Baltic Sea [PDF]

Baltské moře představuje jeden z největších brakických ekosystémů na světě, který je pouze omezeně spojen se Severním mořem přes dánské průlivy. Vyznačuje se silným sezónním kolísáním teploty a výrazným severojižním gradientem salinity.
Kociánová, Barbora
core  

Nutraceutical Benefits of Anchomanes difformis Rhizome and Its Effects on Blood Glucose and Hepatorenal Function in Normoglycemic Rats

Food Chemistry International, EarlyView.
Scientific analysis of Anchomanes difformis roots confirms significant nutraceutical potential, containing high levels of carbohydrates, proteins, and essential minerals. Phytochemical screening revealed antioxidants such as phenols and flavonoids, and although the extracts effectively lowered plasma glucose, safety testing showed dose‐dependent risks.
Lawrence Folorunso Dada, Kingsley Omage, Marshall Arebojie Azeke   +2 more
wiley   +1 more source