Results 171 to 180 of about 4,105 (286)

A Microfibrous Extracellular Matrix Platform for <i>In Vitro</i> Hepatotoxicity Screening: A Next-Generation Model for Humanized Liver Research. [PDF]

ACS Pharmacol Transl Sci
Kaur N, Savitsky MJ, Lipscomb M, Yang D, Ali J.   +4 more
europepmc   +1 more source

The Non-Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF-β-E2F1 Axis. [PDF]

Adv Sci (Weinh)
Zhang J, Zhao Y, Pulivendala G, Zhang Q, Rui L, Gao J, Wang H, Zhang G, Nuotio-Antar A, Tong X, Yin L.   +10 more
europepmc   +1 more source

CD8 T Cell Hyperfunction and Reduced Tumour Control in Murine Models of Advanced Liver Disease. [PDF]

Eur J Immunol
Madani J, Li J, Ching MEA, Vranjkovic A, Jorritsma K, Hasim MS, Daneshmand M, Campeau N, Lawton DA, Bagheri S, Cheung AC, Mulvihill EE, Bruin JE, Ardolino M, Crawley AM.   +14 more
europepmc   +1 more source

Rapid-Onset Drug-Induced Liver Injury Following Amoxicillin-Clavulanate: A Case Report. [PDF]

Clin Case Rep
Khadka S, Dev A, Yadav PS, Acharya S, Karki A, Shah L.   +5 more
europepmc   +1 more source

Advances in Immunological Combination Therapy for Colorectal Cancer

iMetaMed, EarlyView.
Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu, Rongbo Wen, Tianshuai Zhang, Fuao Cao, Xiaoming Zhu, Liqiang Hao, Wei Zhang, Guanyu Yu   +7 more
wiley   +1 more source

PLOD1 promotes the malignancy of hepatocellular carcinoma by facilitating the NF-κB/IL-6/STAT3-dependent TCA cycle. [PDF]

JHEP Rep
Zhang C, Zhou Y, Hu M, Pan Y, Chen X, Sun Q, Ma Z, Wang C, Zha Y, Zhu F, Xia H.   +10 more
europepmc   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Alcohol use disorder: an Australian perspective on screening, diagnosis, treatment and prevention. [PDF]

Intern Med J
Palmer AJ, Connor JP, Clark PJ.
europepmc   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, volume III. [PDF]

Front Pharmacol
Zhu Y, El Demerdash FM, Yang X, Machado MM, Boye A, Sun X.   +5 more
europepmc   +1 more source