Results 91 to 100 of about 7,493 (302)

Determination of Eight Microcystins in Water by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

Renmin Zhujiang, 2022
Microcystins (MCs) are a common class of hepatotoxins mainly produced upon the apoptosis of freshwater blue-green algae and are highly poisonous to human beings and aquatic life.It is of great significance to establish an accurate and rapid detection ...
ZHANG Panwei, LANG Hang, DING Xiangyi, ZHAO Xiaohui, LI Kun, WAN Xiaohong, LI Zheng   +6 more
doaj  

Characterization of a functional C3A liver spheroid model [PDF]

, 2016
More predictive in vitro liver models are a critical requirement for preclinical screening of compounds demonstrating hepatotoxic liability. 3D liver spheroids have been shown to have an enhanced functional lifespan compared to 2D monocultures; however a
Asthana, Bacon, Boelsterli, Bort, Chang, Colley, Curcio, Donato, Esteller, Fey, Forster, Friedrich, Fu, Gissen, Godoy, Gomez-Lechon, Gomez-Lechon, Gomez-Lechon, Guo, Herzog, Honkoop, James, Khetani, Koenig, Lazarou, LeCluyse, LeCluyse, Lippincott, Miyamoto, Mueller, Mueller, Nibourg, Norris, Olive, Peshwa, Ramaiahgari, Reuben, Sainz Jr., Semler, Takahashi, Tostoes, van Zijl, Wang, Wells, Wong, Wrzesinski, Wrzesinski, Wrzesinski, Xia, Yuhas   +49 more
core   +1 more source

A Doxorubicin‐Loaded Liposomes Baghdadite System for Localized Osteosarcoma Therapy and Bone Regeneration

Advanced NanoBiomed Research, EarlyView.
This study presents a multifunctional Baghdadite ceramic implant integrating doxorubicin‐loaded liposomes via ion‐assisted plasma polymer coating for localized osteosarcoma therapy. The platform enables drug retention, sustained release, tumor cell inhibition, osteoconductivity, and antibacterial activity, offering a mechanically robust strategy for ...
Sally Kortam, Zufu Lu, Iman Roohani, Ghazal Shineh, Leila Mamizadeh Janghour, Huu Nguyen Ngoc, Pooria Lesani, Behnam Akhavan, Hala Zreiqat   +8 more
wiley   +1 more source

The Fate of Microcystins in the Environment and Challenges for Monitoring

Toxins, 2014
Microcystins are secondary metabolites produced by cyanobacteria that act as hepatotoxins in higher organisms. These toxins can be altered through abiotic processes, such as photodegradation and adsorption, as well as through biological processes via ...
Justine R. Schmidt, Steven W. Wilhelm, Gregory L. Boyer   +2 more
doaj   +1 more source

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health, EarlyView.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
wiley   +1 more source

Exploring Marine Cyanobacteria for Lead Compounds of Pharmaceutical Importance

The Scientific World Journal, 2012
The Ocean, which is called the “mother of origin of life,” is also the source of structurally unique natural products that are mainly accumulated in living organisms. Cyanobacteria are photosynthetic prokaryotes used as food by humans.
Bushra Uzair, Sobia Tabassum, Madiha Rasheed, Saima Firdous Rehman   +3 more
doaj   +1 more source

SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside

JCI Insight, 2021
Liver regeneration is critical to survival after traumatic injuries, exposure to hepatotoxins, or surgical interventions, yet the underlying signaling and metabolic pathways remain unclear.
Sarmistha Mukherjee, James Mo, Lauren M. Paolella, Caroline E. Perry, Jade Toth, Mindy M. Hugo, Qingwei Chu, Qian Tong, Karthikeyani Chellappa, Joseph A. Baur   +9 more
doaj   +1 more source

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease [PDF]

, 2016
Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to study using current in vitro models such as primary human hepatocyte (PHH) monolayer cultures, as their rapid de-differentiation restricts their usefulness ...
Bell, Catherine C, Dankers, Anita CA, Ellis, Ewa, Fredriksson Puigvert, Lisa, Goldring, Christopher EP, Hendriks, Delilah FG, Ingelman-Sundberg, Magnus, Jacobs, Frank, Jenkins, Rosalind E, Kitteringham, Neil R, Lauschke, Volker M, Mkrtchian, Souren, Moro, Sabrina ML, Nordling, Åsa, Park, B Kevin, Renblom, Anna, Sison-Young, Rowena L, Snoeys, Jan, Walsh, Joanne   +18 more
core   +2 more sources

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Increased Risk of Intrahepatic Cholestasis of Pregnancy in SLE Women Exposed to Azathioprine

Arthritis &Rheumatology, Accepted Article.
Objectives To evaluate the risk of intrahepatic cholestasis of pregnancy (ICP) in azathioprine (AZA)‐exposed versus unexposed SLE pregnancies within the multi‐centre prospective Lupus in prEGnAnCY (LEGACY) cohort. Methods LEGACY is conducted at Systemic Lupus International Collaborating Centres in Canada, South Korea, Peru, and Mexico.
Reem Farhat, Maria del Carmen Zamora‐Medina, Sang‐Cheol Bae, Megan R.W. Barber, Ann E. Clarke, Paul R. Fortin, Zahi Touma, Carl A. Laskin, Isabelle Malhamé, Giada Sebastiani, Christine Peschken, Manuel F. Ugarte‐Gil, Alexandra Legge, Sasha Bernatsky, Évelyne Vinet   +14 more
wiley   +1 more source