Results 201 to 210 of about 34,801 (229)

Iron, Hepcidin, and Immunity

Infection involves the utilization of host nutritional resources by the pathogen. Genetic, experimental, and clinical evidence supports the critical role of iron as a focus for both pathogen attack and host defense. The molecular basis of how mammals regulate iron transport to maintain homeostasis, and in response to infection, has been well ...
Crisell, D, Talbot, N, Drakesmith, H
openaire   +1 more source

Role of Ferroptosis in ALD: Focusing on Hepcidin and Besides Hepcidin

Current Medicinal Chemistry
Ascending incidence and poor outcomes make Alcoholic Liver Disease (ALD) a considerable public health concern. This review concluded the iron metabolism under physiology conditions and alcohol disturbance (leading to ferroptosis in ALD) and summarized the novel treatment, diagnosis, and prognosis of ferroptosis
Leijie Chen, Hejun Zhou, Zongyong Cheng, Deliang Liu, Yuyong Tan   +4 more
openaire   +2 more sources

Hepcidin

Trends in Endocrinology & Metabolism
Tomas Ganz, Elizabeta Nemeth
openaire   +3 more sources

Hepcidin and Iron in Health and Disease

Annual Review of Medicine, 2023
Elizabeta Nemeth, Tomas Ganz
exaly  

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Nature, 2020
Christian Bache Billesbølle, Caleigh M Azumaya, Rachael Kretsch   +2 more
exaly  

Hepcidin and Thalassemia

The Indian Journal of Pediatrics, 2017
openaire   +2 more sources

Hepcidin

2012
Robert L. Sainburg, Andrew L. Clark, George E. Billman, Zachary J. Schlader, Toby Mündel, Kevin Milne, Earl G. Noble, Felipe Querol, Sofia Pérez-Alenda, José A. Aznar, Stavros Apostolakis, Gregory Y. H. Lip, W. Todd Cade, Kevin E. Yarasheski, Linda S. Pescatello, R. H. Fagard, Fabio Manfredini, Roberto Manfredini, Nancy J. Rehrer, Lawrence E. Armstrong, Gemma A. McLeod, Louise Østergaard, Max Gassmann, Luigi Varesio, Michele Samaja, Michael Vogt, Fabio Breil, Hans Hoppeler   +27 more
openaire   +1 more source

Hepcidin and iron

2015
This chapter focuses on the signaling pathways involved in the synthesis of hepcidin, the iron hormone, and discusses the pathophysiological consequences of genetic and nongenetic disruption of its regulation. Hepcidin acts as the principal physiological inhibitor of iron flux into the bloodstream by inhibiting its receptor, the iron exporter ...
Vecchi C., Pietrangelo A.
openaire   +1 more source

Disrupted hepcidin regulation in HFE -associated haemochromatosis and the liver as a regulator of body iron homoeostasis

Lancet, The, 2003
David M Frazer, V Nathan Subramaniam, Gregory J Anderson   +2 more
exaly  

Hepcidin: A Lifesaver

The role of the iron homeostasis mechanism is summarized in this article. Iron plays an important role in managing bodily functions such as growth and development, and makes haemoglobin, and some hormones. Hepcidin acts differently in different conditions; if the body needs more oxygen, the hepcidin levels decrease allowing iron to enter the plasma and
openaire   +1 more source