Results 91 to 100 of about 2,189 (194)

c‐MAF Transcriptionally Activates Slc40a1 to Repress Ferroptosis in Sepsis‐Associated Encephalopathy

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
c‐MAF and its downstream target Slc40a1 were identified as key regulators of ferroptosis in septic mouse hippocampi. Neuron‐specific knockdown of either gene aggravated CLP‐induced cognitive deficits and ferroptosis, whereas their overexpression exerted protective effects.
Wenqin Song, Qianni Shen, Hui Zhang, Xueshan Bu, Wenwei Gao, Wei Wang   +5 more
wiley   +1 more source

Population Pharmacokinetics and Exposure–Response Analyses of Momelotinib, Its Active Metabolite (M21), and Total Active Moiety in Myelofibrosis

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 629-640, March 2026.
Momelotinib, a Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor, is approved for the treatment of myelofibrosis with anemia. These analyses characterized the population pharmacokinetics of momelotinib and its active metabolite M21 following administration of the commercial tablet formulation in patients with myelofibrosis from phase II/III
Benjamin Rich, Meenakshi Srinivasan, Yu Liu Ho, Sandra A.G. Visser, Geraldine Ferron‐Brady, Georgios Vlasakakis   +5 more
wiley   +1 more source

Hepcidin Expression in Psoriasis Patients

Indian Journal of Dermatology, 2014
Background: Iron is an essential nutrient for mammals. Accelerated loss of nutrients through hyperproliferation and desquamation from the skin in psoriasis is known. Hepcidin is an important and recently discovered regulator of iron homeostasis.
Dilek, Nursel, Dilek, Aziz Ramazan, Şahin, Kazım, Kaklikkaya, Neşe, Saral, Yunus   +4 more
openaire   +3 more sources

Prevalence and Risk Factors of Anemia in Pregnant Women Attending Antenatal Clinic at a Medical Center in Accra, Ghana: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Anemia during pregnancy remains a major cause of maternal and infant morbidity in Ghana and has broader socioeconomic implications. Its persistence despite existing interventions indicates that factors such as education, occupation, and nutrition require closer evaluation.
Gifty Amewudah, Frank Twum Aboagye, Frank Quarshie, Martin Owusu Asante, Benjamin Ansah‐Agyei, Joseph Otchere, Philip Narteh Gorleku, Maurice Ofoe Gorleku, Margaret Atuahene, Abena Mantebea Ateko, Daniel Eshun   +10 more
wiley   +1 more source

Anaemia and Maternal Iron Intakes in Pregnancy and Child Asthma: An Observational Analysis From a Longitudinal Cohort

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Evidence supporting the association between anaemia and lower iron intakes during pregnancy with an increased risk of childhood asthma remains unclear. This study aimed to investigate whether (i) lower haemoglobin or anaemia in late pregnancy and (ii) lower mean dietary iron intake in pregnancy were associated with a higher
Emma Hokey, Sophie Callanan, Anna Delahunt, Alexander Douglass, Mohammad Talaei, Seif O. Shaheen, Fionnuala M. McAuliffe   +6 more
wiley   +1 more source

Mast Cell‐Derived CXCL4: A Key Mediator of Ferroptosis and Cardiac Damage in Septic Cardiomyopathy

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Background Septic cardiomyopathy (SCM) is a common and life‐threatening complication of severe sepsis, with high mortality due to unclear underlying mechanisms. CXCL4, a key pro‐inflammatory factor, is implicated in various heart diseases, while ferroptosis (iron and lipid hydrogen peroxide‐dependent regulated cell death) plays a crucial role ...
Jing Wei, Zhi‐ying Jiang, Ling‐feng Ye, Hong‐xiang Lu   +3 more
wiley   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Gene expression profiles of white bass (Morone chrysops) and hybrid striped bass (M. chrysops x M. saxatilis) gill tissue following Flavobacterium covae infection

Comparative Immunology Reports
Columnaris disease is a prevalent disease in freshwater environments caused by the ubiquitous aquatic pathogen Flavobacterium species. Adhesion to the external mucosal surfaces of fishes is the initial stage of infection, and the gills specifically have ...
Linnea K. Andersen, Jason W. Abernathy, Bradley D. Farmer, Miles D. Lange, Matthew E. McEntire, Steven D. Rawles   +5 more
doaj   +1 more source

BiGraph‐DTA: Predicting drug–target interactions of hepatoprotective agents with graph convolutional networks

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Predicting drug–target affinity (DTA) is critical for discovering and developing hepatoprotective agents that can prevent and treat liver diseases. In this study, we propose BiGraph‐DTA, a new predictive model for identifying DTA score prediction for hepatoprotective compounds by combining graph convolutional networks and bidirectional long ...
Arief Sartono, Bambang Riyanto Trilaksono, Sophi Damayanti, Anto Satriyo Nugroho, Firdayani Firdayani   +4 more
wiley   +1 more source

First Case Report of Precursor‐Targeted Immune‐Mediated Anaemia in a Dog From Italy Lacking Rubriphagocytosis and With Severe Hyperferraemia: Diagnosis, Treatment, and Clinical Outcome

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
ABSTRACT Precursor‐targeted immune‐mediated anaemia (PIMA) is an uncommon and poorly understood cause of persistent non‐regenerative anaemia in dogs and cats, characterised by ineffective erythropoiesis and frequently associated with rubriphagocytosis (RP) in bone marrow samples.
Souad Nasar, Annamaria Uva, Giovanna Girardi, Giulia Tanas, Stefano Ciccarelli, Andrea Zatelli, Maria Alfonsa Cavalera, Floriana Gernone   +7 more
wiley   +1 more source