Results 71 to 80 of about 1,905 (175)

Nature's Nanotech Warriors: The Role of Metalloproteins and Protein Cages for Environmental Remediation

Advanced Sustainable Systems, Volume 10, Issue 6, June 2026.
Cartoon representation of five major classes of metalloproteins and their brief mechanisms of bioremediation. The five classes include metallothioneins, metal‐precipitating enzymes, P.‐type ATPases, protein cages, and synthetic metalloproteins (de novo‐designed proteins/peptides for selective adsorption). These natural and engineered protein structures
Sian D'Silva, Celin Acharya, Soumyananda Chakraborti   +2 more
wiley   +1 more source

RETRACTED: The Role of Ubiquitination in Hepcidin-Independent and Hepcidin-Dependent Degradation of Ferroportin

Cell Metabolism, 2011
The iron exporter ferroportin (Fpn) is essential to transfer iron from cells to plasma. Systemic iron homeostasis in vertebrates is regulated by the hepcidin-mediated internalization of Fpn. Here, we demonstrate a second route for Fpn internalization; when cytosolic iron levels are low, Fpn is internalized in a hepcidin-independent manner dependent ...
De Domenico, Ivana, Lo, Eric, Yang, Baoli, Korolnek, Tamara, Hamza, Iqbal, Ward, Diane McVey, Kaplan, Jerry   +6 more
openaire   +2 more sources

Homozygous TFR2 (c.2093_2096del) Mutation in an Asymptomatic Patient With Type 3 Hereditary Hemochromatosis, First Report From Saudi Arabia

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Hereditary hemochromatosis (HH) is an inherited disorder of iron metabolism characterized by progressive iron accumulation in multiple organs. While most cases are associated with HFE mutations, non‐HFE variants such as mutations in the transferrin receptor‐2 (TFR2) gene represent rare causes of iron overload.
Omar M. Raslan, Dana S. Alamoudi
wiley   +1 more source

Hepcidin Expression in Psoriasis Patients

Indian Journal of Dermatology, 2014
Background: Iron is an essential nutrient for mammals. Accelerated loss of nutrients through hyperproliferation and desquamation from the skin in psoriasis is known. Hepcidin is an important and recently discovered regulator of iron homeostasis.
Nursel Dilek, Aziz Ramazan Dilek, Kazim Şahin, Neşe Kaklikkaya, Yunus Saral   +4 more
openaire   +3 more sources

Gene expression profiles of white bass (Morone chrysops) and hybrid striped bass (M. chrysops x M. saxatilis) gill tissue following Flavobacterium covae infection

Comparative Immunology Reports
Columnaris disease is a prevalent disease in freshwater environments caused by the ubiquitous aquatic pathogen Flavobacterium species. Adhesion to the external mucosal surfaces of fishes is the initial stage of infection, and the gills specifically have ...
Linnea K. Andersen, Jason W. Abernathy, Bradley D. Farmer, Miles D. Lange, Matthew E. McEntire, Steven D. Rawles   +5 more
doaj   +1 more source

Diagnostic Accuracy of Inflammatory Biomarkers in Differentiating Acute Appendicitis From Other Acute Abdomen and Predicting Disease Severity: A Prospective Comparative Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Acute appendicitis (AA) is one of the most common clinical conditions for emergency surgery. The diagnosis of acute appendicitis remains challenging for surgeons. Researchers are still looking for a parameter that is less expensive and easily available for diagnosis.
Sintayehu Admas, Bisrat Birke Teketelew, Nigusie Alemu, Berhanu Woldu, Lyusira Marelgn, Getu Girmay, Arega Zenaw, Abebe Birhanu, Yemataw Gelaw   +8 more
wiley   +1 more source

Hepcidin and Cytokines in Anaemia

Hematology, 2004
Hepcidin is a cytokine-induced antibacterial protein which is produced in the liver, circulates in the blood, and is excreted in the urine. It is a major regulator of iron balance in the intestinal mucosa, and appears to have a significant role in the pathogenesis of haemochromatosis and related disorders.
openaire   +2 more sources

Hepcidin is decreased in TFR2 hemochromatosis

Blood, 2005
Abstract The hepatic peptide hepcidin is the key regulator of iron metabolism in mammals. Recent evidence indicates that certain forms of hereditary hemochromatosis are caused by hepcidin deficiency. Juvenile hemochromatosis is associated with hepcidin or hemojuvelin mutations, and these patients have low or absent urinary hepcidin ...
Nemeth, Elizabeta, Roetto, Antonella, Garozzo, Giovanni, Ganz, Tomas, Camaschella, Clara   +4 more
openaire   +3 more sources

Relationship of Genetic Variability (HIF‐1Α (rs11549465; P582S), TMPRSS6 (rs855791; V736A) and ABO (rs651007) and Iron Deficiency in Repeated Blood Donors in 2023: A Cross‐Sectional Study Towards Individualized Health Management

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Frequent blood donation can significantly increase the risk of iron deficiency, influenced by demographic, dietary, environmental, and genetic factors. This study aims to evaluate the association between iron deficiency and specific genetic variations (HIF‐1α (rs11549465; P582S), TMPRSS6 (rs855791; V736A), and ABO (rs651007)
Mohammad Pouya Samiee, Azita Chegini, Majid Shahabi, Amir Teimourpour   +3 more
wiley   +1 more source

Single‐Agent Selinexor Versus Physician's Choice in Previously Treated Myelofibrosis: Results From the Phase 2 XPORT‐035 Study

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Background Janus kinase inhibitors (JAKis), the current standard of care for myelofibrosis (MF), provide clinical benefit, but responses are frequently incomplete, non‐durable, and associated with cytopenias, underscoring the need for therapies with novel mechanisms of action.
Sebastian Grosicki, Habte Yimer, Rosa Ayala, Suning Chen, Hong Liu, Françoise Boyer, Paola Guglielmelli, Marco Brociner, Paolo Sportoletti, Gabor Mikala, Panagiotis Tsirigotis, Jin Zhang, Tomer Mark, Yi Chai, Andrea Ellero, Alessandro Lucchesi   +15 more
wiley   +1 more source