Results 201 to 210 of about 197,589 (314)

Prognostic scoring based on ER, PgR and HER2-low from the CYCLHER study: strengths and unaddressed challenges for global clinical application. [PDF]

Breast
Tan Y, Cheng B, Feng Z, He K, Xie X.
europepmc   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

HER2 Therapies in Non-Small Cell Lung Cancer (NSCLC). [PDF]

Int J Mol Sci
Richani Meinhardt FW, Zambrano Iglesias MI, Fernández Gómez MP, Saltaren Fonseca JF, Hussein A, Raez LE.   +5 more
europepmc   +1 more source

Unfavorable Prognostic Impact of HER2 2+/FISH-Negativity in Older Patients with HER2-Negative and High-Risk Breast Cancer

Hao Wang,1 Miao Yu,1 Meihua Chen,2 Hui Li,1 Shiwei Liu1 1Department of Breast, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and ...
Li H, Yu M, Chen M, Wang H, Liu S
core  

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Treatment of HER2-Positive Brain Metastasis from Cervical Cancer Using Multimodal Therapy Including Pyrotinib: A Case Report. [PDF]

Int J Womens Health
Chen Y, Wen T, Wen X, Lai Z.
europepmc   +1 more source

Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR‐TKIs

Journal of Clinical Laboratory Analysis, EarlyView.
Cancer metabolism has emerged as a critical area of study in cancer research, offering insights into the complex mechanisms underlying tumor growth and development. Lipid metabolic reprogramming, especially the dynamic balance between fatty acid synthesis and fatty acid oxidation, plays significant roles in tumor progression. ABSTRACT Background Cancer
Wenhao Luo, Zun Wang, Guangzhi Ma, Wang Shen, Xiaobo Chen, Yida Liao   +5 more
wiley   +1 more source

Development and internal validation of a nomogram based on HER2 status for predicting pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer. [PDF]

Transl Cancer Res
Chai X, Wei C, Yang T, Zhou H, Du X, Wang Q, Zhang T, Long J.   +7 more
europepmc   +1 more source

Sonographic localisation of lymph nodes suspicious of metastatic breast cancer to surgical axillary levels

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 119-138, March 2025.
Sonographic imaging is used to identify the presence, number and location of malignant lymph nodes. Axillary lymph nodes suspicious of harbouring breast cancer metastasis can be localised to three surgical axillary levels. This paper will unpack the axillary anatomy, muscular sonographic landmarks, surgical axillary lymph node levels and the ...
Michelle Fenech, Tracey Burke, Grace Arnett, Alisha Tanner, Natasha Werder   +4 more
wiley   +1 more source

Omission of Sentinel Lymph Node Biopsy in Breast Cancer: A Real‐World Validation of the Patient Populations of the SOUND and INSEMA Trials

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Treatment guidelines recommending omission of axillary surgery in breast cancer are largely based on the SOUND and INSEMA trials. However, the extent to which their study populations represent real‐world patients remains unclear.
Tia Puiras, Eeva Juhanoja, Anselm Tamminen   +2 more
wiley   +1 more source