Results 221 to 230 of about 281,370 (287)

Synthesis of 1,2,3,4‐Tetrahydroisoquinoline‐3‐Carboxylic Acid‐Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer

ChemistryOpen, EarlyView.
Synthesized decapeptides were designed and validated by in silico studies. They have significantly exhibited anticancer potential against breast cancer and MCF‐7 cell line. The above illustration specifies the synthetic pathway, biological screening, and the mode of action of the peptide in blocking the pathways responsible for the growth of cancer ...
Sunil Tivari, Naurin Lalani, Pritam Bagwe, Prashant Chandole, Ramesh Pawar, Enrique Delgado‐Alvarado, Abdallah Othman Ghnaim, Yashwantsinh Jadeja   +7 more
wiley   +1 more source

Association Between Peripheral Blood Lymphocyte Count and HER2 Status in Breast Cancer: A Retrospective Study. [PDF]

Int J Womens Health
Liang H, Lin Y, Pan K, Wang J, Xie X, Ding M, Lin J.   +6 more
europepmc   +1 more source

What practicing pathologists and oncologists should know about the new computational pathology‐based companion diagnostic tools

The Journal of Pathology, EarlyView.
Abstract The integration of artificial intelligence into pathology is transforming the assessment of histological and immunohistochemical (IHC) slides, offering opportunities to reduce variability and streamline diagnostics. In practical terms, most available tools and research models emulate the diagnostic capabilities of pathologists by detecting ...
Diana Montezuma, Sara P. Oliveira, Inti Zlobec, Nadieh Khalili, Jordi Temprana‐Salvador, Sabine Leh, David Ameisen, Mircea‐Sebastian Șerbănescu, Arsela Prelaj, Jakob Nikolas Kather, Norman Zerbe, Vincenzo L'Imperio   +11 more
wiley   +1 more source

Stratified prediction of HER2 status in breast cancer by integrating intratumoral and peritumoral radiomics from DCE-MRI. [PDF]

BMC Cancer
Gao Y, Gong J, Yang Y, Luo Y, Liu W, Zeng Z.   +5 more
europepmc   +1 more source

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

Diagnostic and Therapeutic Challenges Related to HER2 Heterogeneity in Gastric Cancer: Bridging Molecular Pathology and Clinical Decision-Making. [PDF]

Int J Mol Sci
Rosanu NM, Gervaso L, Lobrano R, Vanoli A, Cella CA, Fusco N, Fazio N.   +6 more
europepmc   +1 more source

HER2陽性転移・再発乳癌に対し，Trastuzumab(H)＋ Pertuzumab(P)＋XC(Capecitabine＋Cyclophosphamide） を投与した２例 [PDF]

, 2017
二宮, 凛, 二宮, 淳, 佐々木, 勝海, 内田, 惠博, 大矢, 真里子, 小島, 誠人, 小川, 利久, 林原, 紀明, 石綱, 一央, 辻, 英一   +9 more
core  

Image Analysis Platform for Comprehensive Quantification of Extracellular Vesicle Morphology

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐encapsulated nanoparticles with key roles in cell biology and growing importance in biomedicine. However, EVs are challenging to characterize because they are highly heterogeneous. Single EV analysis methods are valuable tools for addressing this challenge.
Alexander Spark, Nan Jiang, Benjamin Purnell, Mihajlo Radmilovic, Andras Saftics, Eugenia Romano, Tijana Jovanovic‐Talisman, Alexandre Kitching   +7 more
wiley   +1 more source

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae, Yun‐Jeong Seo, Eun‐Bi Kim, Hyoung‐Min Park, I‐Hsuan Liu, J. Eugene Lee, Jae‐Young Kim   +6 more
wiley   +1 more source