Results 31 to 40 of about 48,931 (300)

Effects of Ginkgo leaf tablets on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism

open access: yesPharmaceutical Biology, 2018
Context: Ginkgo leaf tablets (GLTs) and losartan are often simultaneously used for the treatment of hypertension in Chinese clinics. However, the herb–drug interaction between GLT and losartan is still unknown.
Baiping Dong   +3 more
doaj   +1 more source

Identification of cytochrome P450 isoenzymes involved in the metabolism of 23-hydroxybetulinic acid in human liver microsomes

open access: yesPharmaceutical Biology, 2020
Context 23-Hydroxybetulinic acid (23-HBA), a major active constituent of Pulsatilla chinensis (Bunge) Regel (Ranunculaceae), exhibits potential antitumor activity. Its metabolism, however, has not yet been studied.
Ying Zhou, Jinhua Wen, Guangji Wang
doaj   +1 more source

Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2019
Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could influence the activities of rat enzymes CYP3A4, CYP2D6, CYP1A2, CYP2C19, and CYP2C9 in vivo.
Yiping Lin   +8 more
doaj   +1 more source

Drug-Drug Interaction Potential, Cytotoxicity, and Reactive Oxygen Species Production of Salix Cortex Extracts Using Human Hepatocyte-Like HepaRG Cells

open access: yesFrontiers in Pharmacology, 2021
Herbal preparations of willow bark (Salix cortex) are available in many countries as non-prescription medicines for pain and inflammation, and also as dietary supplements.
João Victor Dutra Gomes   +5 more
doaj   +1 more source

Nutraceutical-based integrative medicine: adopting a mediterranean diet pyramid for attaining healthy ageing in veterans with disabilities [PDF]

open access: yes, 2018
Veterans with disability represent a big burden worldwide and often require long-term rehabilitation. Unhealthy dietary and lifestyle habits, including smoke and alcohol abuse, are common in veterans.
Aiello, Paola   +9 more
core   +1 more source

Herb–drug interactions: a mechanistic approach

open access: yesDrug and Chemical Toxicology, 2020
In India, traditional herbal medicines have been an essential part of therapy for the last centuries. However, a large portion of the general populace is using these therapies in combination with allopathy lacking a proper understanding of possible interactions (synergistic or antagonistic) between the herbal product and the allopathic drug.
Ajay Kumar, Sharma   +2 more
openaire   +2 more sources

Possible Drug–Herb Interaction between Herbal Supplement Containing Horsetail () and Antiretroviral Drugs

open access: yesJournal of the International Association of Providers of AIDS Care, 2017
The use of alternative medicines, including herbs, is common among HIV-positive patients, even in those on antiretroviral treatment. Equisetum arvense , known as “horsetail,” is mainly used for its diuretic properties.
Ezequiel Cordova MD   +2 more
doaj   +1 more source

Investigating herb–drug interactions: the effect of Citrus aurantium fruit extract on the pharmacokinetics of amiodarone in rats [PDF]

open access: yes, 2013
Citrus aurantium extract has been largely used in weight loss and sports performance dietary supplements. However, the safety of C. aurantium-containing products has been questioned mainly due to the association of its use with adverse events in the ...
Alves, Gilberto   +2 more
core   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

open access: yesAngewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. [PDF]

open access: yes, 2017
Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause ...
Feng, Xiaoyi   +17 more
core   +2 more sources

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