Results 61 to 70 of about 48,931 (300)

Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1‐mediated macrophage polarization via the PI3K/Akt pathway

Animal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing identified secreted phosphoprotein 1 (SPP1) as a crucial target through which methylophiopogonanone A (MOA) ameliorates pulmonary fibrosis. Molecular docking and microscale thermophoresis (MST) assays confirmed a favorable binding affinity between MOA and SPP1.
Fan Yang, Tian Li, Weiran Jia, Dingjie Xu, Liangdan Sun, Yanlei Ge, Yiwei Shi, Hong Xu, Xudong Song, Fuyu Jin, Na Mao   +10 more
wiley   +1 more source

In vitro interaction between Agrimonia eupatoria L.: Extracts and antibiotic [PDF]

Kragujevac Journal of Science, 2017
Synergistic activity between water, acetone, ethanol and diethyl ether extract of Agrimonia eupatoria L. and commonly used antibiotic (ampicillin) were evaluated.
Muruzović Mirjana Ž., Mladenović Katarina G., Stefanović Olgica 0000-0003-1255-7706, Žugić-Petrović Tanja K., Čomić Ljiljana R.   +4 more
doaj   +1 more source

Effect of Combined Leaf Extracts of Vernonia amygdalina (Bitter Leaf) and Gongronema latifolium (Utazi) on the Pancreatic beta-Cells of Streptozotocin- Induced Diabetic Rats [PDF]

, 2011
The study evaluated the effect of combined extracts of Vernonia amygdalina (VA) and Gongronema latifolium (GL) on the pancreas of streptozotocin (STZ) induced diabetic Wistar rats. Thirty-two (32) albino rats were divided equally into 4 groups.
Akpantah, Amabe, Akpaso, Mfon I, Atangwho, Item J, Ebong, Patrick E, Fischer, Victor A, Igiri, Anozeng O.   +5 more
core   +1 more source

Pharmacological evaluation of Adenostemma lavenia acetone extract in Swiss Albino mice: Analgesic, anti‐inflammatory, and thrombolytic insights from in vivo, in vitro, density functional theory, and molecular docking studies

Animal Models and Experimental Medicine, EarlyView.
Adenostemma lavenia, a traditionally used medicinal plant, has been employed to manage pain, inflammation, and circulatory issues. This study investigates the analgesic, anti‐inflammatory, and thrombolytic potentials of the acetone extract of A. lavenia leaves (AEAL) using in vivo, in vitro, and in silico methods.
Nusrat Jahan Moon, Mahathir Mohammad, Md. Jahirul Islam Mamun, Fahmina Binty Azim Nova, Nazmul Hasan Eshaque, Md. Hossain Rasel, Zobayed Islam, Md. Mahmudul Hasan, Md. Liakot Ali, Md. Tanvir Chowdhury, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study

International Journal of Analytical Chemistry, 2019
This study aimed to develop a selective, simple, and sensitive HPLC-MS/MS method for the simultaneous determination of schisandrin and promethazine (PMZ) with its metabolite in rat plasma, which was further used for a pharmacokinetic herb-drug ...
Sijia Gao, Xuelin Zhou, Liwei Lang, Honghong Liu, Jianyu Li, Haotian Li, Shizhang Wei, Dan Wang, Zhuo Xu, Huadan Cai, Yanling Zhao, Wenjun Zou   +11 more
doaj   +1 more source

In vitro evaluation of the inhibition potential of echinacoside on human cytochrome P450 isozymes

BMC Complementary Medicine and Therapies, 2022
Background Echinacoside (ECH) possesses a wide range of biological activity. This present study analyzes the effect of ECH on cytochrome P450 isozymes (CYPs) activities of human liver microsomes.
Yujie Wu, Aiqing Qiao, Shu Lin, Lijia Chen   +3 more
doaj   +1 more source

Artemisinin: From Chinese Herbal Medicine to Modern Chemotherapy [PDF]

, 2019
Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material.
Butler, Anthony
core   +1 more source

Pregnancy, prescription medicines and the potential risk of herb-drug interactions:a cross-sectional survey [PDF]

, 2017
Funding All funding was from institutional resource. JSM, AS are employed by the University of Aberdeen. DS is employed by the Robert Gordon University. BP and CR are employed by NHS Scotland.
A Fugh-Berman, A Lupattelli, A Smeriglio, A Steel, A Vickers, AA Izzo, AA Mitchell, Abdul R. Pallivalapila, AR Pallivalapila, AR Pallivalapilla, AR Pallivalapilla, Ashalatha Shetty, Binita Pande, CH Chuang, Craig Rore, DA Forster, DA Kennedy, Derek Stewart, E Ernst, F Facchinetti, GG Briggs, H Nordeng, H Nordeng, HG Hall, J Adams, J Boivin, J Henderson, James S. McLay, JJ Dugoua, JR Daw, K Moussally, K Moussally, KJ Hunt, KM Kuczkowski, L Cuzzolin, L Holst, M Elvin-Lewis, M Tabatabaee, MC Mothupi, ME Palmer, Moza Al Hail, Naila Izzati, O Stephansson, P Posadzki, RE Graham, RE Westfall, RJ Ko, S Eardley, TC Clarke, W Abebe   +49 more
core   +4 more sources

Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats

Pharmaceutical Biology, 2019
Context: Omeprazole and astragaloside IV (AS-IV) are widely used for the treatment of gastric ulcers in China clinics. Objective: This study investigates the effects of AS-IV on the pharmacokinetics of omeprazole in rats.
Wei Liu, Guozhi Liu, Jing Liu
doaj   +1 more source

The effects of triptolide on the pharmacokinetics of sorafenib in rats and its potential mechanism

Pharmaceutical Biology, 2017
Context: Combining sorafenib with triptolide could inhibit tumour growth with greater efficacy than single-agent treatment. However, their herb–drug interaction remains unknown.
Xianming Wang, Xin Zhang, Fei Liu, Minghai Wang, Shiyong Qin   +4 more
doaj   +1 more source