Results 131 to 140 of about 3,171 (206)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1685-1695, June 2026.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

A Core Outcome Set for Efficacy of Acute Treatment of Hereditary Angioedema [PDF]

Acute treatment; Delphi; Hereditary angioedemaTratamiento agudo; Delphi; Angioedema hereditarioTractament agut; Delphi; Angioedema hereditariBackground Clinical trials investigating drugs for the acute treatment of hereditary angioedema attacks have ...
Weller, Karsten, Petersen, Remy Sanne, Magerl, Markus, Fijen, Lauré, Aberer, Werner, Guilarte, Mar, Apfelbacher, Christian, Gil Serrano, Ingrid Johana   +7 more
core   +1 more source

Hypokalemic Periodic Paralysis in a Young Woman With Mast Cell Activation Syndrome: A Case Report of an Atypical Presentation Associated With an Ultra‐Rare CACNA1S Variant

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Hypokalemic periodic paralysis (hKPP) is a rare neuromuscular channelopathy characterized by transient episodes of muscle weakness or paralysis associated with low serum potassium levels. It has been most commonly linked to autosomal dominant mutations in ion channel genes, specifically CACNA1S and SCN4A, which impair skeletal muscle ...
Ali Moradi, Yasmin Aboutaleb, Saba Noreen, Abdullah Sahyouni, Hasin Sharma, Olugbenga Oyesanmi, Ian M. Kahane, Yizhi Lin, Hakan R. Toka   +8 more
wiley   +1 more source

Value co-creation in healthcare: evidences from innovative therapeutic alternatives for Hereditary Angioedema

, 2016
Value co-creation in healthcare: evidences from innovative therapeutic alternatives for Hereditary ...
Lamacchia, D., SPANO', ROSANNA, BARBARINO, ALESSANDRO, DI PAOLA, NADIA, BOVA, MARIA, Genovese, A.   +5 more
core  

Clinical Impact of Peripheral Attacks in Hereditary Angioedema Patients

, 2012
BackgroundEpisodes of acute subcutaneous angioedema affecting the extremities in patients with known hereditary angioedema are called peripheral attacks. These attacks are considered to be of limited clinical importance.ObjectiveTo evaluate the impact of
M. Cicardi, Cicardi, Marco, J. H. Nuijens, Levy, Robyn J., A. Relan, D. Moldovan, Zuraw, Bruce, B. Zuraw, A. Kusuma, Nuijens, Jan H., Moldovan, Dumitru, Hack, C. Erik, A. C. Knulst, Relan, Anurag, Knulst, André C., R. J. Levy, Kusuma, Andy, C. E. Hack   +17 more
core   +1 more source

Angiotensin Converting Enzyme Inhibitor-related Angioedema: A Case of an Unexpected Death

Iranian Journal of Allergy, Asthma and Immunology, 2015
Angioedema is an asymmetric non-pitting oedema on face, lips, tongue and mucous membranes; any delay in diagnosis and treatment can be fatal. Treatment with lisinopril as an angiotensin converting enzyme (ACE) inhibitor, can be a reason of angioedema ...
Eray Atalay, Mehmet Tamer Özdemir, Gülşen Çiğsar, Ferhat Omurca, Nurullah Aslan, Mehmet Yildiz, Zehra Bahar Gey   +6 more
doaj  

Exploring Floristic Diversity and Medicinal Plant Uses in Venda, Limpopo, South Africa

Feddes Repertorium, Volume 137, Issue 2, June 2026.
ABSTRACT Plants have been an important source of medicine for thousands of years. To better understand the current diversity and usage of medicinal plants, floristic studies are essential. This report documents an expedition conducted in the Venda region of Limpopo, South Africa. The study was carried out in Shanzha and surrounding villages, as well as
Gurusamy Manikandan, Iliassou L. Mouafon, David R. Katerere   +2 more
wiley   +1 more source

Mimics of hereditary angioedema

Nasljedni (hereditarni) angioedem je bolest karakterizirana periodičnim, nepredvidivim oticanjima mekih tkiva različitih lokalizacija i intenziteta s najčešće samoograničavajućim tijekom trajanja, te je u pravilu posredovan bradikininom.
Karanović, Boris, Smiljanić Tomičević, Ljiljana, Barešić, Marko, Anić, Branimir   +3 more
core   +1 more source

Efficacy of MAPK inhibitors in children with neurodegenerative Langerhans cell histiocytosis: Results from the European Consortium for Histiocytosis

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Neurodegenerative Langerhans cell histiocytosis (ND‐LCH) is a severe and debilitating complication of LCH with no effective treatment. In this study, we assessed the efficacy of MAPK inhibitors (MAPKi) in a large cohort of children with ND‐LCH. We included pediatric patients with ND‐LCH who received MAPKi between 2013 and 2025.
Francesco Pegoraro, Francois Chalard, Dmitry Evseev, Mohamed Barkaoui, Solenne Le Louet, Julian Thalhammer, Nathalie Aladjidi, Alexandra Salmon, Perrine Marec‐Berard, Stefania Gaspari, Carmela De Fusco, Irene Trambusti, Antonio Verrico, Anna Raciborska, Karel Svojgr, Zdenka Křenová, Olga Slater, Gerard Millen, Myriam Ben Arush, Dana Ashkenazi Lustig, Tatiana Von Bahr Greenwood, Caroline Hutter, Itziar Astigarraga, Mónica López‐Duarte, Lorena Valero‐Arrese, María José Ortega Acosta, Cor van den Bos, Leonie Naeije, Daniel Martin‐Munoz, Anna Perrone, Marzia Mortilla, Olivier Felician, Ahmed Idbaih, Sébastien Héritier, Vasanta Nanduri, Milen Minkov, Jan‐Inge Henter, Elena Sieni, Jean Donadieu   +38 more
wiley   +1 more source

Trends in Asthma‐Rhinitis Allergic Multimorbidity and Polysensitization in China: The CARRAD Study

MedComm, Volume 7, Issue 6, June 2026.
This cross‐sectional study highlights the increasing prevalence of allergic diseases and comorbidities under environmental conditions of rapid modernization in China. Our observations underline the relevance of the allergic comorbidities phenotype at the clinical and public health levels.
Wanjun Wang, Jianhong Wang, Guihua Song, Hua Xie, Rongfei Zhu, Yong He, Jun Tang, Junge Wang, Jinghua Yang, Lili Zhi, Lin Wu, Yan Jiang, Xiaoqin Zhou, Dongming Huang, Ning Wang, Rui Xu, Yuan Gao, Zhimin Chen, Xiaoli Han, Guolin Tan, Jinzhun Wu, Deyu Zhao, Jianjun Chen, Weixi Zhang, Yuemei Sun, Yi Jiang, Weitian Zhang, Qianhui Qiu, Chuanhe Liu, Jie Yin, Guodong Hao, Huabin Li, Yongsheng Xu, Shaohua Chen, Shi Chen, Juan Meng, Dan Zeng, Wei Tang, Chuangli Hao, Nanshan Zhong, Jing Li, the China Alliance of Research on Respiratory Allergic Disease (CARRAD)   +41 more
wiley   +1 more source