Results 121 to 130 of about 111,576 (246)

Hereditary angioedema: An underdiagnosed disease

, 2019
O angioedema hereditário é uma desordem autossômica dominante com prevalência de 1: 10.000 – 50.000 pessoas, relativamente rara, decorrente de mutacões genéticas que determinam deficiência quantitativa ou qualitativa do inibidor de C1 esterase.
Rodrigues, Larissa R. L, Portilho, Nathália Coelho, Betti, Nádia de Melo, Amore, Patrícia Nogueira, Rodrigues, Lorena R. L., Italiano, Noele B. C.   +5 more
core   +1 more source

Long‐Term Renal Function and Clinical Outcomes of Sacubitril/Valsartan in HFrEF and Stage 3–4 Chronic Kidney Disease: A 24‐Month Single‐Centre Cohort

Clinical Cardiology, Volume 49, Issue 9, September 2026.
In this 24‐month, single‐centre cohort of 360 patients with HFrEF and stage 3–4 chronic kidney disease, sacubitril/valsartan was well tolerated, with stable renal function, improved symptoms, and low rates of renal events and mortality. These descriptive findings are hypothesis‐generating and warrant confirmation in controlled studies.
Fatih Akkaya, Onur Osman Şeker, Ercan Türkmen, Seçkin Dereli   +3 more
wiley   +1 more source

CRISPR‐Cas9 and precision editing technologies linking functional genomics to clinical translation in genetic diseases

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRISPR‐Cas9 and precision editing technologies enable a variant‐mechanism‐driven framework for genetic disease research and therapeutic development. Pathogenic variants are first interpreted according to mutation type, coding or regulatory consequence, tissue context, and disease mechanism.
Zijing Wen, Jianming Su
wiley   +1 more source

“Effects of High‐Intensity Ultrasound on the Structural, Technofunctional, and Allergenic Properties of Groundnut (Arachis hypogaea L.) Protein Isolates: A Review”

Food Chemistry International, Volume 2, Issue 3, Page 298-315, September 2026.
ABSTRACT The growing global demand for sustainable, nutritionally balanced protein sources has intensified interest in plant‐derived proteins, particularly those derived from oilseeds such as groundnut (Arachis hypogaea L.). However, although groundnut protein isolates (GPIs) have high nutritional quality, they exhibit limitations in technofunctional ...
Ángel Efraín Rodríguez Rivera, Kevin Ulises López Martír, Judith Esmeralda Urías Silvas, Juan Alberto Resendiz Vazquez, Raúl Delgado Delgado, María Soledad Córdova Aguilar, Antonio Hidalgo Millan   +6 more
wiley   +1 more source

Role of Non‐Thermal Processing Technologies in Modulating Protein Allergenicity in Legumes

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Non‐thermal processing technologies (NTTs) reduce legumes' allergenicity while preserving quality and nutrients retention (PEF, pulsed electric field; CP, cold plasma; HPP, high pressure processing; US, ultrasound; IR, infrared). ABSTRACT The global shift toward plant‐based diets has increased legume consumption due to health and environmental benefits.
Viateur Ngabonzima, Flora G. C. Ekezie, Alberta N. A. Aryee, John O. Onuh   +3 more
wiley   +1 more source

Genome Editing for Glycogen Storage Diseases

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Gene therapy has been developed for several glycogen storage diseases and has advanced into clinical trials. However, the limitations of these gene therapies with regard to stability following treatment early in life have led to the development of genome editing.
Troy von Beck, Raymond Wang, Dwight Koeberl   +2 more
wiley   +1 more source

Dermatologic Best Practices for Manicures and Nail Care: A Systematic Review

JEADV Clinical Practice, Volume 5, Issue 3, Page 821-828, September 2026.
This systematic review shows emerging evidence that nail cosmetic practices pose significant dermatologic consequences, particularly among individuals with regular nail salon use. Emerging concerns include infectious complications, an expanding spectrum of acrylate‐related contact allergens, structural disruption and loss of normal nail unit anatomy ...
Nivetha Aravind, Olivia Burke, Brian W. Morrison   +2 more
wiley   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

The Role of Complement in Hereditary Angioedema

, 2019
Low levels of C1 inhibitor, the main inhibitor of the classic complement system, result in paroxysmal angioedema attacks that can be incapacitating or even life-threatening in affected individuals.
Levi, Marcel, Cohn, Danny M.
core   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter, Ian M. Adcock, Cristina Benito‐Villalvilla, Rodolfo Bianchini, Leif Bjermer, Gaetano Caramori, Luigi Cari, Kian Fan Chung, Zuzana Diamant, Ibon Eguiluz‐Gracia, Edward F. Knol, Milos Jesenak, Francesca Levi‐Schaffer, Giuseppe Nocentini, Liam O'Mahony, Oscar Palomares, Frank Redegeld, Milena Sokolowska, Betty Van Esch, Marco Zurlo, Cristiana Stellato   +20 more
wiley   +1 more source