Results 61 to 70 of about 144,374 (198)

Psychological Correlates in Subjects with Hereditary Angioedema (HAE)

Journal of Psychology & Psychotherapy, 2014
Objectives: Hereditary Angioedema (HAE) is a rare serious medical condition caused by a deficiency of C1-inhibitor, due to mutations in its structural gene. The disease appears clinically as cutaneous swelling of the extremities, face, genitals, and trunk, painful swelling of the gastrointestinal mucosa and life threatening laryngeal edema.
openaire   +1 more source

A clinical evaluation of patients with known mutations (plasminogen and factor XII) with a focus on prophylactic treatment

Journal of Dermatological Treatment
Background Hereditary angioedema with normal C1-inhibitor (HAE-nC1-INH) is a rare genetic disease. The symptoms can resemble other forms of hereditary angioedema (HAE), but the specific laboratory values are inconspicuous.
Robin Lochbaum, Susanne Trainotti, Thomas K. Hoffmann, Jens Greve, Janina Hahn   +4 more
doaj   +1 more source

Fresh Frozen Plasma in Hereditary Angioedema Crisis: To Give or Not To Give?

European Journal of Case Reports in Internal Medicine, 2015
Objectives: Fresh frozen plasma (FFP) has been used in angioedema crises, however there is a risk of aggravating the symptoms as well as transmitting infections. In this report, the authors emphasize the dangers of this therapy. Materials and methods: A
Jamal Belkhouribchia, Sara Nguyen
doaj   +1 more source

Switching Long‐Term Prophylaxis to Donidalorsen for Hereditary Angioedema: 1‐Year OASISplus Results

Allergy, Volume 81, Issue 8, Page 2833-2842, August 2026.
This study evaluated the long‐term safety and efficacy of donidalorsen in patients who switched from a long‐term prophylactic treatment (LTP) to donidalorsen with 1‐year outcomes. Patients who switched from LTP to donidalorsen experienced a 67.6% reduction in HAE attack rates over 52 weeks.
Marc A. Riedl, Jonathan A. Bernstein, Joshua S. Jacobs, Timothy Craig, William R. Lumry, H. James Wedner, Aleena Banerji, Selina Gierer, Andrew Smith, Michael E. Manning, Francesca Perego, Laura Bordone, Sabrina Treadwell, Tao Lin, Kenneth B. Newman, Aaron Yarlas, Danny M. Cohn   +16 more
wiley   +1 more source

Modeling Hereditary Angioedema With Personalized Expanded Potential Stem Cell‐Derived Hepatocytes: A CRISPR‐Validated Platform for Mutation‐Specific Mechanisms and Therapeutic Innovation

Allergy, Volume 81, Issue 8, Page 2858-2873, August 2026.
Patient‐derived expanded potential stem cell (EPSC) hepatocytes reveal that pathogenic SERPING1 variants cause distinct cellular defects in hereditary angioedema. While most mutations reduce SERPING1 transcription and C1‐INH secretion, a large deletion induces intracellular C1‐INH retention.
Xueyan Liu, Yuxin Wang, Jane C. Y. Wong, Xiang Zhang, Cuixi Wu, Pengyu Chen, Yunzhi Yang, Pentao Liu, Chak Sing Lau, Matthew Cook, Philip Hei Li   +10 more
wiley   +1 more source

Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication [PDF]

, 2012
This guideline was provided by the Japanese Association for Complement Research targeting clinicians for making an accurate diagnosis of hereditary angioedema (HAE), and for prompt treatment of the HAE patient in Japan.
Matsushita, Misao, Taroh Kinoshita, Masashi Mizuno, Okada, Hidechika, Takahiko Horiuchi, Okada, Noriko, Nobutaka Wakamiya, Nakao, Miki, Matsumoto, Misako, Yamamoto, Tetsuro, Nonaka, Masaru, Tetsuro Yamamoto, Hidechika Okada, Kinoshita, Taroh, Misako Matsumoto, Fujita, Teizo, Noriko Okada, Hatanaka, Michiyo, Wakamiya, Nobutaka, Endo, Yuichi, Mizuno, Masashi, Tsukasa Seya, Horiuchi, Takahiko, Miki Nakao, Ohi, Hiroyuki, Tsukamoto, Hiroshi, Yuichi Endo, Norimitsu Inoue, Hiroshi Tsukamoto, Teizo Fujita, Hiroyuki Ohi, Misao Matsushita, Isao Ohsawa, Ohsawa, Isao, Inoue, Norimitsu, Michiyo Hatanaka, Masaru Nonaka, Seya, Tsukasa   +37 more
core   +1 more source

Ecallantide is a novel treatment for attacks of hereditary angioedema due to C1 inhibitor deficiency

, 2011
Henriette Farkas, Lilian Varga3rd Department of Internal Medicine, Semmelweis University, Budapest, HungaryAbstract: Hereditary angioedema (HAE) resulting from the deficiency of the C1 inhibitor protein is a rare disease, characterized by paroxysms of ...
null Varga, Henriette Farkas, Farkas H, Varga L   +3 more
core   +1 more source

Hereditary angioedema with normal C1-inhibitor levels: a rare case report

Revista Portuguesa de Medicina Geral e Familiar
Hereditary angioedema (HAE) is a rare, hereditary disease and its manifestations may be life-threatening. It differs from histaminergic angioedema since it shows different underlying mechanisms and, therefore, does not respond to antihistamine or ...
Filipa Rodrigues dos Santos, Inês Falcão, Leonor Cunha   +2 more
doaj   +1 more source

Breakthroughs in hereditary angioedema management: a systematic review of approved drugs and those under research

Drugs in Context, 2019
Hereditary angioedema (HAE) is a rare genetic disorder, characterized by recurrent and unexpected potentially life-threatening mucosal swelling. The impairment underlying HAE could be a defect in C1-inhibitor activity, or in its serum concentration ...
Stefania Nicola, Giovanni Rolla, Luisa Brussino   +2 more
doaj   +1 more source

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 8, Page e1034-e1044, August 2026.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source