Results 11 to 20 of about 39,162 (280)

Clinical, Molecular and Geographical Features of Hereditary Breast/Ovarian Cancer in Latvia [PDF]

open access: yesHereditary Cancer in Clinical Practice, 2005
Introduction The aim of the study is to evaluate the incidence and phenotype-genotype characteristics of hereditary breast and ovarian cancer syndromes in Latvia in order to develop the basis of clinical management for patients and their relatives ...
Gardovskis Andris   +10 more
doaj   +2 more sources

SEOM clinical guidelines in hereditary breast and ovarian cancer (2019) [PDF]

open access: yesClinical and Translational Oncology, 2019
Mutations in BRCA1 and BRCA2 high penetrance genes account for most hereditary breast and ovarian cancer, although other new high-moderate penetrance genes included in multigene panels have increased the genetic diagnosis of hereditary breast and ovarian
S. González-Santiago   +9 more
semanticscholar   +3 more sources

Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in Cypriot population. [PDF]

open access: yes, 2010
Inability to correctly repair DNA damage is known to play a role in the development of breast cancer. Single nucleotide polymorphisms (SNPs) of DNA repair genes have been identified, which modify the DNA repair capacity, which in turn may affect the risk
Daniel, M   +9 more
core   +7 more sources

Investigating the impact of NHS based ovarian cancer screening [PDF]

open access: yes, 2010
the UK ovarian cancer is the fifth most common cancer in females and after uterine cancer, the second most common gynaecological cancer. There were 6,596 new cases diagnosed in the UK in 2006.
Nicholson, S. M.
core   +7 more sources

[Hereditary breast and ovarian cancer].

open access: yesDer Pathologe, 2017
Hereditary breast and ovarian carcinomas are frequently caused by germline mutations of the BRCA1 and BRCA2 genes (BRCA1/2 syndromes) and are often less associated with other hereditary syndromes such as Li-Fraumeni and Peutz-Jeghers.
S. Lax
semanticscholar   +2 more sources

Evaluation of the Rosa Chatbot Providing Genetic Information to Patients at Risk of Hereditary Breast and Ovarian Cancer: Qualitative Interview Study

open access: yesJournal of Medical Internet Research, 2023
Background Genetic testing has become an integrated part of health care for patients with breast or ovarian cancer, and the increasing demand for genetic testing is accompanied by an increasing need for easy access to reliable genetic information for ...
E. Siglen   +5 more
semanticscholar   +1 more source

Extended genetic analysis and tumor characteristics in over 4600 women with suspected hereditary breast and ovarian cancer

open access: yesBMC Cancer, 2023
Background Genetic screening for pathogenic variants (PVs) in cancer predisposition genes can affect treatment strategies, risk prediction and preventive measures for patients and families.
Anna Öfverholm   +16 more
semanticscholar   +1 more source

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk [PDF]

open access: yes, 2013
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were
Side, Lucy E.,   +999 more
core   +4 more sources

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. [PDF]

open access: yes, 2012
Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility ...
Dutra-Clarke, Ana   +999 more
core   +4 more sources

Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer

open access: yesBreast Cancer Research, 2019
Background The role of the BARD1 gene in breast cancer (BC) and ovarian cancer (OC) predisposition remains elusive, as published case-control investigations have revealed controversial results.
Nana Weber-Lassalle   +28 more
doaj   +1 more source

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