Results 41 to 50 of about 39,162 (280)

Cost-effectiveness of Population-Wide Genomic Screening for Hereditary Breast and Ovarian Cancer in the United States

JAMA Network Open, 2020
Key Points Question Is it cost-effective to implement population-wide genomic screening for hereditary breast and ovarian cancer (HBOC)? Findings This decision analytical model study found that genomic screening for HBOC among unselected women may be ...
G. Guzauskas, S. Garbett, Zilu Zhou, S. Spencer, H. Smith, J. Hao, D. Hassen, Susan R. Snyder, J. Graves, J. Peterson, Marc S. Williams, D. Veenstra   +11 more
semanticscholar   +1 more source

Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer

Breast Care, 2021
Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer.
K. Rhiem, B. Auber, S. Briest, N. Dikow, N. Ditsch, N. Dragicevic, S. Grill, E. Hahnen, J. Horváth, B. Jaeger, K. Kast, M. Kiechle, E. Leinert, S. Morlot, Michael Püsken, D. Schäfer, S. Schott, C. Schroeder, U. Siebers-Renelt, C. Solbach, N. Weber-Lassalle, I. Witzel, C. Zeder-Göss, R. Schmutzler   +23 more
semanticscholar   +1 more source

Phenotype analysis of families with TP53 germline variants at the Center for Familial Breast and Ovarian Cancer, Cologne

Cancer Medicine
Purpose Tumor protein p53 (TP53) pathogenic variant (PV) carriers are identified during genetic testing for hereditary causes of cancer. PVs in TP53 are associated with the Li‐Fraumeni syndrome (LFS), and thus, surveillance and preventive measures are ...
K. Kast, K. Rhiem, M. Larsen, B. Wappenschmidt, R. Schmutzler   +4 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Histopathological characterization of carcinoma breast with BRCA1/2 sequence variation in a Tertiary Care Center in Kerala, South India

Biomedical and Biotechnology Research Journal, 2022
Background: Hereditary breast cancers constitute around 5%–10% of all breast cancers. The most commonly mutated genes in hereditary breast and ovarian cancer syndrome are the BRCA1 and BRCA2 genes.
Reeba Mary Issac, Prema Saldanha, Jessy Mangalathu Mathai, Jency Mathews, Rebecca Mathews, Bindu Kumari, Tiju Chacko   +6 more
doaj   +1 more source

Interdisciplinary risk counseling for hereditary breast and ovarian cancer: real-world data from a specialized center

Archives of Gynecology and Obstetrics, 2022
Purpose Hereditary breast and ovarian cancer has long been established to affect a considerable number of patients and their families. By identifying those at risk ideally before they have been diagnosed with breast and/or ovarian cancer, access to ...
Benedikt Zang, M. Helms, Laura Besch, N. Kalmbach, Stephanie Stegen, J. Blohmer, D. Speiser   +6 more
semanticscholar   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

BRCA1 and BRCA2 mutations in a population-based study of male breast cancer [PDF]

, 2001
Background: The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC) in the United Kingdom is not known, and the importance of these genes in the increased risk of female breast cancer associated with a family history of breast ...
Bruce AJ Ponder, Julian M Lipscombe, Joanna M Ward, Basham, VM, Easton, DF, Ward, JM, Ponder, BAJ, Victoria M Basham, Simon A Gayther, Paul DP Pharoah, Lipscombe, JM, Douglas F Easton, Pharoah, PDP, Gayther, SA   +13 more
core   +2 more sources

Genetic, clinic and histopathologic characterization of BRCA-associated hereditary breast and ovarian cancer in southwestern Finland

Scientific Reports, 2022
We have analyzed the histopathological, clinical, and genetic characteristics in hereditary breast and ovarian cancer patients of counselled families from 1996 up to today in the southwestern Finland population. In this study we analyzed the incidence of
Terhi Aino-Sofia Pallonen, Salla Maria Matleena Lempiäinen, Titta Kristiina Joutsiniemi, Riitta Irmeli Aaltonen, Pia Erika Pohjola, Minna Kristiina Kankuri-Tammilehto   +5 more
doaj   +1 more source