Results 61 to 70 of about 39,162 (280)

An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers

BMC Cancer, 2020
Background BRCA1/2 germline mutation related cancers are candidates for new immune therapeutic interventions. This study was a hypothesis generating exploration of genomic data collected at diagnosis for 19 patients.
Ewa Przybytkowski, Thomas Davis, Abdelrahman Hosny, Julia Eismann, Ursula A. Matulonis, Gerburg M. Wulf, Sheida Nabavi   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Investigating the potential for expediting diagnosis of ovarian cancer via prompt symptom recognition & "targeted screening" [PDF]

, 2009
PhDThis thesis explores the potential for using symptoms as a tool to bring forward the diagnosis of ovarian cancer. Current evidence supports the existence of prediagnostic symptoms, however symptom lead time has yet to be adequately quantified ...
Lim, Anita Wey Wey
core   +4 more sources

Evaluation of non-canonical p53 functions in DNA replication and recombination for variant classification

Cell Death and Disease
Pathogenic germline TP53 variants predispose to diverse Li-Fraumeni syndrome (LFS) phenotypes and a broad cancer spectrum, whereby carriers of hypomorphic variants cluster in a cohort with attenuated disease onset and an overrepresentation of breast ...
Rebecca Jansche, Benedikt Heitmeir, Ulrike Faust, Helmut Pospiech, Christian Sutter, Christian Albig, Finja Hennig, Wolfgang Janni, Rita Schmutzler, Jan Hauke, Andreas C. Joerger, Lisa Wiesmüller   +11 more
doaj   +1 more source

BRCA1 mutations in Brazilian patients

Genetics and Molecular Biology, 2004
BRCA1 mutations are known to be responsible for the majority of hereditary breast and ovarian cancers in women with early onset and a family history of the disease.
Juliano Javert Lourenço, Fernando R. Vargas, José Bines, Elizete M. Santos, Cezar A. P. Lasmar, Célia H. Costa, Eliane M. B. Teixeira, Maria C. M. Maia, Fátima Coura, Carlos H. D. Silva, Miguel A. M. Moreira   +10 more
doaj   +1 more source

Hereditary Breast and Ovarian Cancer Syndromes

Asian Pacific Journal of Environment and Cancer
Women who inherit a mutation in the BRCA1 or BRCA2 gene are much more likely to develop breast and ovarian cancer. A woman’s specific risk depends on many factors including her age, whether she has a BRCA1 or BRCA2 mutation, and her medical and family ...
Nadia Ghasemi Darestani, Ramin Ghasemi Darestani, Soheyla Hshemi, Zahra Rahimi, Raheleh Janghorbanian Poodeh   +4 more
semanticscholar   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Non-BRCA1/2 Variants Detected in a High-Risk Chilean Cohort With a History of Breast and/or Ovarian Cancer

Journal of Global Oncology, 2019
PURPOSE: Little is known about the genetic predisposition to breast and ovarian cancer among the Chilean population, in particular genetic predisposition beyond BRCA1 and BRCA2 mutations.
Christina Adaniel, Francisca Salinas, Juan Manuel Donaire, Maria Eugenia Bravo, Octavio Peralta, Hernando Paredes, Nuvia Aliaga, Antonio Sola, Paulina Neira, Carolina Behnke, Tulio Rodriguez, Soledad Torres, Francisco Lopez, Claudia Hurtado   +13 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Increased prevalence of colorectal adenomas in women with breast cancer [PDF]

, 2005
Background: The frequency of colorectal adenomas and carcinomas was investigated in a large cohort of women with breast cancer in comparison with matched controls, since data on the occurrence of second tumors in women with breast cancer is controversial.
Späth, Lydia, Eiermann, Wolfgang, Sackmann, Michael, Göke, Burkhard, Ochsenkühn, Thomas, Wiebecke, Baldur, Bayerdörffer, Ekkehard, Meining, Alexander, Mannes, Gerd Alexander, Ochsenkühn, T;Bayerdörffer, E;Meining, A;Späth, L;Mannes, GA;Wiebecke, B;Eiermann, W;Sackmann, M;Göke, B   +9 more
core   +1 more source