Results 71 to 80 of about 39,162 (280)

Evaluation of healthcare management issues in the provision of clinical services for familial breast/ovarian cancer [PDF]

, 2009
Electronic version does not contain associated previously published materialDespite there being pragmatic national guidelines for assigning risk to women with a family history of breast cancer, the evidence base is still sparse.
de Azevedo Moreira Reis, Marta
core   +2 more sources

Identification of women at risk for hereditary breast and ovarian cancer in a sample of 1000 Slovenian women: a comparison of guidelines

BMC Cancer, 2021
Background An important number of breast and ovarian cancer cases is due to a strong genetic predisposition. The main tool for identifying individuals at risk is recognizing a suggestive family history of cancer.
Urska Kotnik, Borut Peterlin, Luca Lovrecic   +2 more
doaj   +1 more source

Multi‐gene panel analysis in BRCA1/2‐negative patients suspected of hereditary breast and ovarian cancer syndrome: Real‐world data from a single institution

The journal of obstetrics and gynaecology research
Although BRCA1/2 is most frequently associated with hereditary breast and ovarian cancer (HBOC), many other related genes have been implicated.
Mariko Nakahara, M. Ushiama, N. Tanabe, Masahiro Gotoh, H. Sakamoto, Teruhiko Yoshida, M. Hirata   +6 more
semanticscholar   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Pedigree and BRCA gene analysis in breast cancer patients to identify hereditary breast and ovarian cancer syndrome to prevent morbidity and mortality of disease in Indian population

Tumor Biology, 2017
Global burden of breast cancer is expected to increase to >2 million new cases every year by 2030 and 10% of these are likely to have hereditary breast and ovarian cancer syndrome.
Mina Darooei, Subhadra Poornima, Bibi Umae Salma, Gayatri R Iyer, Akhilesh N Pujar, Srirambhatla Annapurna, Ashwin Shah, Srinivas Maddali, Qurratulain Hasan   +8 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

40 years of progress in female cancer death risk: a Bayesian spatio-temporal mapping analysis in Switzerland [PDF]

, 2015
In the past decades, mortality of female gender related cancers declined in Switzerland and other developed countries. Differences in the decrease and in spatial patterns within Switzerland have been reported according to urbanisation and language region,
Probst-Hensch, Nicole, Thürlimann, Beat, Beat Thürlimann, Ess, Silvia, Christian Herrmann, Christian Herrmann (235961), Penelope Vounatsou, Beat ThĂźrlimann (3512576), Silvia Ess, Nicole Probst-Hensch (520032), Penelope Vounatsou (49253), Nicole Probst-Hensch, Silvia Ess (3512573), Vounatsou, Penelope, Herrmann, Christian   +14 more
core   +2 more sources

Four magnetic resonance imaging surveillance-detected breast cancer cases in cancer-free BRCA1/2 mutation carriers

Surgical Case Reports, 2021
Background Hereditary breast and ovarian cancer (HBOC) syndrome is a susceptibility syndrome for cancers, such as breast and ovarian cancer, and BRCA1/2 are its causative genes.
Megumi Takaoka, Shozo Ohsumi, Yuichiro Miyoshi, Mina Takahashi, Seiki Takashima, Kenjiro Aogi, Teruhiko Shimizu, Norihiro Teramoto, Yasuko Yamamoto, Miki Okamura   +9 more
doaj   +1 more source

Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation

Journal of Medical Genetics, 2020
Germline DNA tests to identify pathogenic variants in genes linked to hereditary breast and ovarian cancer susceptibility have become widely available. However, the clinical utility of genetic testing depends on reliable evidence-based classification of ...
A. Monteiro, P. Bouwman, A. N. Kousholt, D. Eccles, G. Millot, J. Masson, M. Schmidt, S. Sharan, R. Scully, L. Wiesmüller, F. Couch, M. Vreeswijk   +11 more
semanticscholar   +1 more source