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Hereditary nonpolyposis colorectal cancer: preventive management
Cancer Treatment Reviews, 2003Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer. Inherited mutations in the mismatch repair genes associated with this syndrome have an approximate 80% lifetime risk of colorectal cancer. Since there are no premonitory signs of susceptibility to HNPCC, family history is the initial method for ...
Hwei-Ju, Annie Yu +3 more
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Strategies for Identifying Hereditary Nonpolyposis Colon Cancer
Seminars in Oncology, 2007Hereditary nonpolyposis colorectal cancer (HNPCC) is the term given to a predisposition syndrome caused by inherited mutations in one of at least five DNA mismatch repair (MMR) genes. Dominant mutations in these genes predispose individuals to a range of cancers in addition to the most frequent, colorectal cancer. Endometrial cancer is the most notable
D Gareth, Evans +3 more
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Genetic Testing for Hereditary Nonpolyposis Colorectal Cancer
The American Surgeon, 2003Approximately 80 per cent of patients with colorectal cancer have sporadic disease whereas the remaining 20 per cent seem to have a genetic component. Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common autosomal dominant hereditary syndrome predisposing to colorectal cancer.
Rebecca, Hoedema +6 more
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Hereditary Nonpolyposis Colon Cancer
2009Colorectal cancer affects 148,300 patients in the United States annually (72,600 males and 75,700 females) causing 56,600 deaths each year. Those patients who have two or more first-and/or second-degree relatives with colorectal cancer have a potentially definable inheritable disorder.
David E. Beck +4 more
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Segregation analysis of hereditary nonpolyposis colorectal cancer
Genetic Epidemiology, 1986AbstractSegregation analysis of eleven families comprising 2762 individuals indicated compatibility of the data with segregation of a major autosomal dominant gene for hereditary nonpolyposis colorectal cancer. It was estimated that between 71% and 79% of the gene carriers were susceptible and had age of onset that was normally distributed with mean ...
Joan E. Bailey‐Wilson +7 more
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[Hereditary nonpolyposis colorectal cancer].
Ugeskrift for laeger, 1996Hereditary non polypous colon cancer (HNPCC) is inherited in a dominant fashion, and accounts for 29-39% of all colon and rectum carcinomas occurring in people under 50 years of age. We present a case of a young male with a short history of fluctuating diarrhoea and bleeding per rectum. Family records showed a high incidence of colon and rectum cancer.
C, Eithz, H T, Vaesel, T A, Knudsen
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Surgical Management of Hereditary Nonpolyposis Colorectal Cancer
Advances in Surgery, 2011HNPCC is a diverse disease with significant colorectal and extracolonic malignancy risk. A high index of suspicion is necessary to identify patients and families who potentially have this disease. Patients suspected with Lynch syndrome should be referred for genetic counseling and testing for accurate diagnosis. Timely surveillance and intervention are
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Hereditary Nonpolyposis Colon Cancer
American Journal of Nursing, 1998R J, Cavalieri, B, Franklin
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Current Approaches in Hereditary Nonpolyposis Colorectal Cancer
Journal of the National Comprehensive Cancer Network, 2012This article emphasizes the central role of tumor-based testing for microsatellite instability followed by performance of genetic counselor-driven germline mutation testing in hereditary nonpolyposis colorectal cancer (HNPCC). Suitably aggressive colorectal neoplasm surveillance is shown to be critical.
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