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Hereditary Colon Cancer: Polyposis and Nonpolyposis Variants [PDF]

Ca-A Cancer Journal for Clinicians, 1985
Henry T Lynch, Paul Rozen, Guy S Schuelke   +2 more
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Identifying Hereditary Nonpolyposis Colorectal Cancer

New England Journal of Medicine, 1998
The recent discovery of the genetic basis of certain familial aggregations of colorectal cancer validated 90 years of clinical observation suggesting that such aggregations are hereditary.1 It also...
H T, Lynch, T C, Smyrk
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[Hereditary nonpolyposis colorectal cancer].

Nihon rinsho. Japanese journal of clinical medicine, 2004
Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer (CRC). The disease carries a >80% lifetime risk of CRC (mean age at diagnosis being 46 years). The CRCs that arise in HNPCC are usually right-sided and associated with synchronous and metachronous tumors.
Masaaki, Matsukawa, Terushige, Yamamoto, Takahiko, Kouda   +2 more
  +5 more sources

Pathology of Hereditary Nonpolyposis Colorectal Cancer

Annals of the New York Academy of Sciences, 2000
Abstract: The magnitude of the pathologist's role in the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) is underestimated. The diagnostic features are not specific to HNPCC cancers, but relate to all cancers showing high levels of DNA microsatellite instability (MSI‐H).
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Hereditary Gastrointestinal Polyposis and Nonpolyposis Syndromes

New England Journal of Medicine, 1994
Colon cancer is one of the most frequent cancers in men and women in the United States.1 There is a 6 percent lifetime risk of colon cancer in the general population.1 Approximately 160,000 new cases arise every year, and despite advances in detection and therapy, 60,000 people die of colon cancer and its complications each year.2 Epidemiologic studies
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Extracolonic Cancer in Hereditary Nonpolyposis Colorectal Cancer

Cancer, 1990
It has been hypothesized that in some but not all families with hereditary nonpolyposis colorectal cancer (HNPCC) there is a high risk of certain cancers other than colon cancer.The authors compared the observed frequency of cancer at specific sites in more than 1300 high-risk members of 23 kindreds with HNPCC with expectations based on general ...
P, Watson, H T, Lynch
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Hereditary Nonpolyposis Colorectal Cancer

2007
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant colon cancer syndrome. The first description of a cancer-prone family with HNPCC dates back to the late 1800s.1 However, it was not until the work of Lynch in the 1970s that a more complete clinical picture of this disorder began to emerge.2,3 The diagnosis of HNPCC has, until ...
Erik C. Thorland, Stephen N. Thibodeau
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Rectal cancer in hereditary nonpolyposis colorectal cancer

American Journal of Surgery, 2001
Hereditary nonpolyposis colorectal cancer (HNPCC) accounts for approximately 2% to 5% of all colorectal cancers. Rectal cancer in HNPCC is not well characterized.A retrospective medical record review of HNPCC patients with colorectal cancer diagnosis from December 1948 to December 1999 was performed in an attempt to elucidate the natural history of ...
Nicholas J Petrelli, MIGUEL A Rodriguez-Bigas   +1 more
exaly   +3 more sources

[Hereditary nonpolyposis colorectal cancers].

Praxis, 1996
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal, dominantly inherited disease leading to a marked increase in cancer susceptibility, notably colorectal cancer, affecting up to one in 400 individuals in the Western world. Four genes responsible for the majority of cases have been identified.
S, Caplin, M T, Constanda, J C, Givel
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Hereditary Nonpolyposis Colorectal Cancer

2010
Hereditary nonpolyposis colorectal cancer (HNPCC) is one of two distinct inherited colorectal cancer syndromes with known genetic defects. It is estimated to account for approximately 5% of all large bowel cancers. Originally called Lynch syndrome after Dr. Henry Lynch, it is an autosomal dominant disorder characterized by a predilection for colorectal
W. Donald Buie, Anthony R. MacLean
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