Results 161 to 170 of about 1,218,415 (224)

Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation. [PDF]

J Gen Physiol, 2019
Shi YP, Thouta S, Cheng YM, Claydon TW.
europepmc   +1 more source

NS1643 enhances the activity of T1019PfsX38 and Q1070X hERG channels associated with long QT syndrome type 2. [PDF]

Pflugers Arch
Al Salmani MK, Al Kharusi A, Al Rawahi M, Albarwani S.   +3 more
europepmc   +1 more source

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome.

J Mol Cell Cardiol, 2019
Cheng H, Du C, Zhang Y, James AF, Dempsey CE, Abdala AP, Hancox JC.   +6 more
europepmc   +1 more source

Exploring the Role of Metabolites in Torsadogenic Risk Assessment: A Text-Mining Approach. [PDF]

Turk J Pharm Sci
Bilgin E, Tuğcu G, Aydın A.
europepmc   +1 more source

Dynamical Nonequilibrium Molecular Dynamics Simulations Reveal Atomistic Steps of C-Type Inactivation in Cardiac hERG Channels. [PDF]

J Am Chem Soc
Costa F, Bassetto C, Bezanilla F, Giacomello A.   +3 more
europepmc   +1 more source

Personalized <i>in silico</i> modeling of cardiac ion channel variants to predict drug-induced proarrhythmia risk. [PDF]

Front Physiol
Henedi A, Cherkaoui J, Camara Dit Pinto S, Levine SM, Cherkaoui M, Gallo NR, Benzeroual KE.   +6 more
europepmc   +1 more source

The Hidden Cost of QTc Assessment: A Quantitative Weight of Evidence Framework to Eliminate Structural False Positives and Restore the Lost Opportunity Cost of Abandoned Medicines. [PDF]

Clin Pharmacol Ther
Abernathy MM, Benson CT, Leishman DJ.
europepmc   +1 more source

Lipid-dependent regulation of Kv10.1 in cancer: implications of membrane remodeling for channel function and pharmacology. [PDF]

Front Pharmacol
Phuong NV, Stary-Weinzinger A.
europepmc   +1 more source

Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds.

Am J Physiol Regul Integr Comp Physiol, 2019
Hull CM, Genge CE, Hobbs Y, Rayani K, Lin E, Gunawan M, Shafaattalab S, Tibbits GF, Claydon TW.   +8 more
europepmc   +1 more source