Results 141 to 150 of about 1,218,415 (224)

Off-label use of chloroquine, hydroxychloroquine, azithromycin and lopinavir/ritonavir in COVID-19 risks prolonging the QT interval by targeting the hERG channel. [PDF]

Eur J Pharmacol, 2021
Zequn Z, Yujia W, Dingding Q, Jiangfang L.   +3 more
europepmc   +1 more source

Integrating AI and Molecular Modeling for Structural Prediction of a Closed-Pore State of the hERG Channel. [PDF]

J Chem Inf Model
Upex C, Osborne T, Biglino G, Hancox JC, Corey RA.   +4 more
europepmc   +1 more source

Probucol-induced hERG Channel Reduction can be Rescued by Matrine and Oxymatrine in vitro. [PDF]

Curr Pharm Des, 2020
Shi YQ, Fan P, Zhang GC, Zhang YH, Li MZ, Wang F, Li BX.   +6 more
europepmc   +1 more source

α-mannosidase I-dependent N-linked glycosylation affects hERG channel functional availability during reactivation. [PDF]

J Physiol Sci
Wei M, Sun H, Yin Y, Liu Y, Wang P, Yoshimura K, Kume S, Kurokawa T, Ono K, Ding L, Zheng M.   +10 more
europepmc   +1 more source

Modeling hERG Channel Liability: From Structural Insight to Highly Accurate Qualitative and Quantitative Models. [PDF]

J Chem Inf Model
Sun H, Wang Y, Shen M.
europepmc   +1 more source

The PAS domain directly regulates hERG channel gating in patch-clamp fluorometry recordings. [PDF]

Biophys J
Trudeau MC.
europepmc   +1 more source

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine. [PDF]

Physiol Rep, 2020
El Harchi A, Butler AS, Zhang Y, Dempsey CE, Hancox JC.   +4 more
europepmc   +1 more source

Insights into Hepatic, Neuronal, and hERG Channel Safety of Plant-Derived Active Compounds. [PDF]

J Xenobiot
Kasemnitichok Y, Lee S, Kwon OB, Plengsuriyakarn T, Na-Bangchang K.   +4 more
europepmc   +1 more source

hERG Channel Blockade and Antagonistic Interactions of Three Steroidal Alkaloids from <i>Fritillaria</i> Species. [PDF]

Molecules
Lu H, Hao T, Zhang Z, Jiang C, Xu J, Stalin A, Zhao W.   +6 more
europepmc   +1 more source

KCNH2-L693P Causes Long QT Syndrome Type 2 Through hERG Channel Dysfunction: Functional Validation of a Variant of Uncertain Significance. [PDF]

Mol Genet Genomic Med
Zheng XF, Chen Q, Lu XT, Dai HL, Guang XF.   +4 more
europepmc   +1 more source