Results 131 to 140 of about 1,218,415 (224)

Regulation of HERG channel bio-processing

, 2011
The long QT syndrome (LQTS) is a common cardiac disorder with potentially lethal consequences. While mostly asymptomatic, LQTS patients may develop Torsade de Pointes (TdP) arrhythmia, which can proceed into ventricular fibrillation causing death.
Sroubek, Jakub
core  

Mathematical modelling of hERG channel kinetics using sinusoidal voltage protocols

, 2017
Drug block of the hERG channel is a primary focus of existing cardiac proarrhythmic safety assessment strategies. hERG plays a fundamental role in repolarization of the cardiac action potential and block of this channel can lead to prolongation of, and ...
Mirams, Gary B., Gary R. Mirams, Remi Bardenet, Kylie A. Beattie, Louttit, JB, Beattie, KA, Hill, AP, Vandenberg, JI, Teun P. de Boer, David J. Gavaghan, De Boer, TP, Adam P. Hill, Jamie I. Vandenberg, James B. Louttit, Bardenet, R, Gavaghan, David J.   +15 more
core   +1 more source

Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating. [PDF]

Proc Natl Acad Sci U S A, 2021
Harley CA, Bernardo-Seisdedos G, Stevens-Sostre WA, Jones DK, Azevedo MM, Sampaio P, Lorga-Gomes M, Trudeau MC, Millet O, Robertson GA, Morais-Cabral JH.   +10 more
europepmc   +1 more source

Reassessing the Conduct of Patch Clamp Cardiac Ion Channel Assays to Improve Nonclinical Data Translation to Clinical ECG Changes and Proarrythmia Risk

Clinical and Translational Science
The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative proposes integrating multi‐cardiac ion channel pharmacology to improve the prediction of drug‐induced Torsade de Pointes (TdP) risk.
Claudia Alvarez Baron, Jun Zhao, Donglin Guo, Sabyasachy Mistry, Ryan De Palma, Omnia A. Ismaiel, Wendy W. Wu   +6 more
doaj   +1 more source

Stereoselective Blockage of Quinidine and Quinine in the hERG Channel and the Effect of Their Rescue Potency on Drug-Induced hERG Trafficking Defect

, 2016
Diastereoisomers of quinidine and quinine are used to treat arrhythmia and malaria, respectively. It has been reported that both drugs block the hERG (human ether-a-go-go-related gene) potassium channel which is essential for myocardium repolarization ...
Yanhui Shi, Pan Fan, Meng Yan, Lifang Feng, Junnan Wang, Baoxin Li, Ge Zhan   +6 more
core   +1 more source

Parallel Recordings of Transmembrane hERG Channel Currents Based on Solvent-Free Lipid Bilayer Microarray. [PDF]

Micromachines (Basel), 2021
Miyata R, Tadaki D, Yamaura D, Araki S, Sato M, Komiya M, Ma T, Yamamoto H, Niwano M, Hirano-Iwata A.   +9 more
europepmc   +1 more source

Restoration of mutant hERG stability by inhibition of HDAC6 [PDF]

The human ether-a-go-go-related gene (hERG) encodes the α subunit of a rapidly activating delayed-rectifier potassium (IKr) channel. Mutations of the hERG cause long QT syndrome type 2 (LQT2).
90294321, Morikawa, Kumi, ヒサトメ, イチロウ, Hisatome, Ichiro, マハティ, エンダン, Horie, Minoru, 26953, 3385, 26952, 26955, Kurata, Yasutaka, 26954, 倉田, 康孝, 26957, 26956, ニノミヤ, ハルアキ, 100000740, 李, 佩俐, 90707217, 白吉, 安昭, 100000304, 2609, 100000307, 森川, 久未, 1879, クラタ, ヤスタカ, 40464292, Taufiq, Fikri, リ, ペイリ, 檜垣, 克美, Shirayoshi, Yasuaki, モリカワ, クミ, ヒガキ, カツミ, 60211504, Mahati, Endang, Ninomiya, Haruaki, 2265, Higaki, Katsumi, 90249946, Li, Peili, 80212124, 685, 100000212, 765, 久留, 一郎, 100000877, シラヨシ, ヤスアキ, 二宮, 治明   +47 more
core   +1 more source

Electrophysiological, biochemical and immuncytochemical characterization of C-terminal HERG (LQT2) mutations

, 2008
In fünf nicht verwandten Familien wurden unterschiedliche Mutationen gefunden, welche alle im C-Terminus von HERG lokalisiert waren und deren Träger insbesondere unter emotional oder durch Stress ausgelösten kardialen Attacken litten.
Choe, Chi-un
core  

Molecular mechanisms regulating HERG channel synthesis and trafficking

, 2011
The HERG potassium channel is responsible for cardiac repolarization. Studies of HERG synthesis and trafficking reveal that the protein is sensitive to perturbations, both intrinsic to the protein and environmental.;I first postulated a link between ...
Krishnan, Yamini
core  

Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block. [PDF]

PLoS One, 2020
Tran PN, Sheng J, Randolph AL, Baron CA, Thiebaud N, Ren M, Wu M, Johannesen L, Volpe DA, Patel D, Blinova K, Strauss DG, Wu WW.   +12 more
europepmc   +1 more source