Cell-Based hERG Channel Inhibition Assay in High-Throughput Format. [PDF]
Methods Mol Biol, 2022 Zhao J, Xia M.
europepmc +1 more source
Molecular dynamics simulations suggest possible activation and deactivation pathways in the hERG channel. [PDF]
Commun Biol, 2022 Costa F, Guardiani C, Giacomello A.
europepmc +1 more source
Predicting hERG channel blockers with directed message passing neural networks. [PDF]
RSC Adv, 2022 Shan M +5 more
europepmc +1 more source
Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits. [PDF]
, 2014 KCNE1 (E1) β-subunits assemble with KCNQ1 (Q1) voltage-gated K(+) channel α-subunits to form IKslow (IKs) channels in the heart and ear. The number of E1 subunits in IKs channels has been an issue of ongoing debate.
Dai, Hui +3 more
core
BMC BiologyBackground Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity.
Zhipei Liu +14 more
doaj +1 more source
Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk. [PDF]
Heart Rhythm, 2021 Burashnikov A +8 more
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Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating. [PDF]
Proc Natl Acad Sci U S A, 2021 Harley CA +10 more
europepmc +1 more source
, 2018 The potassium voltage-gated channel subfamily H member 2 (KCNH2) gene encodes the Kv11.1 potassium channel, which conducts the rapidly activating delayed rectifier current in the heart.
Gong, Qiuming +2 more
core
CardioTox net: a robust predictor for hERG channel blockade based on deep learning meta-feature ensembles. [PDF]
J Cheminform, 2021 Karim A, Lee M, Balle T, Sattar A.
europepmc +1 more source
Parallel Recordings of Transmembrane hERG Channel Currents Based on Solvent-Free Lipid Bilayer Microarray. [PDF]
Micromachines (Basel), 2021 Miyata R +9 more
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