Results 121 to 130 of about 1,218,415 (224)
Molecular dynamics simulations suggest possible activation and deactivation pathways in the hERG channel. [PDF]
Commun Biol, 2022 Costa F, Guardiani C, Giacomello A.
europepmc +1 more source
The Journal of Physiology, Volume 604, Issue 19, Page 8069-8099, 1 October 2026.Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger +4 more
wiley +1 more source
In silico screening on the herg potassium channel [PDF]
, 2011 Während des Arzneistoffentwicklungsprozesses scheitern fast 35% der Arzneistoffe wegen schlechter Absorption, Verteilung, Metabolismus, Ausscheidung und Toxizität (ADMET).
Schiesaro, Andrea
core
, 2009 The hERG potassium channel is highly related to severe cardiac side effects. With the technique of homology modelling it is possible to model the homo tetrameric subunits of the hERG channel in the closed and open state, using KcsA and KirBac1.1 as well ...
A. WINDISCH +5 more
core +1 more source
Predicting hERG channel blockers with directed message passing neural networks. [PDF]
RSC Adv, 2022 Shan M +5 more
europepmc +1 more source
Identification of Sodium/Myo‐Inositol Transporter 1 as a Major Determinant of Arterial Contractility
The FASEB Journal, Volume 40, Issue 18, 30 September 2026.The tonicity‐responsive enhancer binding‐protein (TonEBP) and serum glucocorticoid kinase (SGK) sense a rise in extracellular hypertonicity resulting in an increase SMIT1 membrane abundance in vascular smooth muscle cells. SMIT1 associates with Kv7.4/5, Gβγ, and KCNE4, promoting hyperpolarization, reduced voltage‐gated calcium channel (VGCC) opening ...
Elizabeth A. Forrester +6 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 18, 28 September 2026.The acid‐sensing ion channel 3 (ASIC3), physiologically located in the peripheral nervous system, was found in stem cells of CNS‐located glioblastoma multiforme (GBM CSCs); its chronic activation in the CNS kills dysfunctional GBM CSCs with no effect on ASIC3‐lacking CNS tissues.
Leonardo Maiorana +8 more
wiley +1 more source
Drug block of the hERG potassium channel: Insight from modeling
, 2007 Many commonly used, structurally diverse, drugs block the human ether-a-go-go-related gene (hERG) K+ channel to cause acquired long QT syndrome, which can lead to sudden death via lethal cardiac arrhythmias. This undesirable side effect is a major hurdle
Brian Cox (4465927) +14 more
core +1 more source
Open Channel Block of HERG K ϩ Channels by Vesnarinone [PDF]
, 2020 Vesnarinone, a cardiotonic agent, blocks I Kr and, unlike other I Kr blockers, produces a frequency-dependent prolongation of action potential duration (APD).
John S Mitcheson +4 more
core
Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk. [PDF]
Heart Rhythm, 2021 Burashnikov A +8 more
europepmc +1 more source