Results 101 to 110 of about 1,218,415 (224)

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Voltage protocol design for determining hERG channel kinetics

, 2015
Drug interactions with cardiac ion channels can cause disturbances to normal electrical activity in the heart. In particular, hERG channel block has been linked with QT prolongation and increased pro-arrhythmic risk. Consequently, hERG channel screening,
Mirams, Gary, de Boer, Teun, Gavaghan, David, Beattie, Kylie, Louttit, James   +4 more
core   +1 more source

Epicardial adipose tissue‐linked leukotriene and cytokine signalling pathways – novel targets for prevention of obesity‐ and diabetes‐linked ventricular arrhythmia

The Journal of Physiology, EarlyView.
Kelly A. Aromolaran, Ademuyiwa S. Aromolaran   +1 more
wiley   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Molecular regulation of the HERG potassium channel

, 2004
The dynamic regulation of membrane excitability determines the human heart rhythm and governs cardiac adaptation to changes in physiologic demands.
Kagan, Anna
core  

Chlorothiophene‐Substituted N‐Phenylpyrazolines: Synthesis, Anticancer Evaluation, and Computational Insight into COX‐2 Inhibition

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Eight novel N‐phenylpyrazoline derivatives bearing chlorothiophene moieties were synthesized and evaluated for anticancer activity against T47D, MCF7, and WiDr cell lines. Compound 2g showed the strongest cytotoxicity against WiDr cells (IC50 = 19.63 µg/mL) with the highest selectivity index (665.88), highlighting its potential as a selective ...
Nikma Farismatur Riza, Fia Fathiana Wulan, Tegar Asanda Ghifari, Endang Astuti, Tutik Dwi Wahyuningsih   +4 more
wiley   +1 more source

Integrated Biological Evaluation of Benzimidazolium–Chalcone Derivatives: Antioxidant, Anti‐AChE, Anticancer, and Anti‐MRSA Activities With Docking Insights

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Four benzimidazolium–chalcone derivatives were synthesized and explored for their multifunctional biological activities. The compounds exhibit distinct antioxidant, AChE inhibitory, antibacterial, antibiofilm, and apoptotic activities, supported by molecular docking analysis.
Mehmet Çimentepe, Hakan Ünver, Adem Necip, Mehmet Ersatir, Burcu Demirbağ, Özge Öztürk Çimentepe, Metin Yildirim   +6 more
wiley   +1 more source

Do Stimulants Promote Arrhythmic Risk: Insights From a Human‐Induced Pluripotent Stem Cell‐Derived Cardiomyocyte Model

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
At clinically relevant plasma concentrations, stimulant medications produced minimal effects on conduction velocity but modulated automaticity and repolarization in a hiPSC‐derived cardiomyocyte (hiPSC‐CM) model. These findings provide a foundation for future investigations of stimulant‐associated cardiac safety and support the utility of hiPSC‐CM ...
Alia Arslanova, Samantha Wong, Sonia Franciosi, Glen F. Tibbits, Maksymilian Prondzynski, Shubhayan Sanatani   +5 more
wiley   +1 more source

Superparamagnetic iron oxide nanoparticles (SPIONs) modulate hERG ion channel activity

, 2019
Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used in various biomedical applications, such as diagnostic agents in magnetic resonance imaging (MRI), for drug delivery vehicles and in hyperthermia treatment of tumors.
Tadini-Buoninsegni, Francesco, Fantechi, E., Tadini-Buoninsegni, F., Moncelli, M. R., Sangregorio, C., Moncelli, Maria Rosa, Sangregorio, Claudio, Gualdani, Roberta, Guerrini, Andrea, Guerrini, A., Fantechi, Elvira   +10 more
core   +1 more source

Tripterine Liposome Exerts Antitumor and Immunomodulatory Effects in Pancreatic Ductal Adenocarcinoma

MedComm, Volume 7, Issue 10, October 2026.
Tripterine liposome (TP‐lipo) exerts anti‐pancreatic ductal adenocarcinoma (PDAC) effects through direct suppression of tumor cells and modulation of the tumor microenvironment (TME). TP‐lipo induces apoptosis and inhibits the clonogenicity, migration, and invasion of KPC cells in vitro.
Lirui Tang, Yi Lin, Xueqin Jiang, Xiaohe Tian, Giuseppe Battaglia, Yuquan Wei, Wenshuang Wu, Xuemei He, Xiawei Wei   +8 more
wiley   +1 more source