Results 111 to 120 of about 17,722 (214)

The conduction pore of a cardiac potassium channel. [PDF]

, 1998
Ion channels form transmembrane water-filled pores that allow ions to cross membranes in a rapid and selective fashion. The amino acid residues that line these pores have been sought to reveal the mechanisms of ion conduction and selectivity. The pore (P)
Goldstein, SA, Tai, KK
core  

Inhibition of Nonsense-Mediated mRNA Decay by Antisense Morpholino Oligonucleotides Restores Functional Expression of hERG Nonsense and Frameshift Mutations in Long-QT Syndrome

, 2010
Mutations in the human ether-a-go-go-related gene (hERG) cause long-QT syndrome type 2 (LQT2). We previously described a homozygous LQT2 nonsense mutation Q1070X in which the mutant mRNA is degraded by nonsense-mediated mRNA decay (NMD) leading to a ...
Bhuiyan, Bhuiyan, Conti, Curran, Dominski, Friedman, Frischmeyer, Gong, Gong, Gritz, Holbrook, Howard, Jearawiriyapaisarn, Kapplinger, Khajavi, Kuzmiak, Le Hir, Le Roy, Linde, Lykke-Andersen, Matthew R. Stump, Millat, Nagy, Napolitano, Nicholson, Qiuming Gong, Sanguinetti, Schwartz, Shimizu, Splawski, Stalder, Tester, Trudeau, Usuki, Wu, Yao, Zhang, Zhengfeng Zhou, Zhou, Zhou   +39 more
core   +1 more source

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]

, 2020
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark, Paik, David T, Wu, Joseph C   +2 more
core  

A Heterozygous Missense hERG Mutation Associated with Early Repolarization Syndrome

Cellular Physiology and Biochemistry, 2018
Background/Aims: Early repolarization syndrome (ERS) has been recently recognized as early repolarization pattern with idiopathic ventricular fibrillation. However, the genetic background of ERS has not been fully understood.
Yun-Jiu Cheng, Hao Yao, Cheng-Cheng Ji, Xu-Miao Chen, Jun Fan, Li-Juan Liu, Su-Hua Wu   +6 more
doaj   +1 more source

ERG1A K+ channel increases intracellular calcium concentration through modulation of calsequestrin1 in C2C12 myotubes

Scientific Reports
The ERG1A K+ channel modulates the protein degradation that contributes to skeletal muscle atrophy by increasing intracellular calcium concentration ([Ca2+]i) and enhancing calpain activity, but the mechanism by which the channel regulates the [Ca2+]i is
Gregory H. Hockerman, Evan Pratt, Shalini Guha, Emily LaVigne, Clayton Whitmore, Omar Khader, Natalie McClure, Sandra Zampieri, Jennifer Koran, W.-H. Wang, Amber L. Pond   +10 more
doaj   +1 more source

Procaine, a State-Dependent Blocker, Inhibits HERG Channels by Helix Residue Y652 and F656 in the S6 Transmembrane Domain

Journal of Pharmacological Sciences, 2013
The article evaluated the inhibitory action of procaine on wild-type and mutated HERG potassium channel current (IHERG) to determine whether mutations in the S6 region are important for the inhibition of IHERG by procaine.
Na Wang, Ji Hua Ma, Pei Hua Zhang
doaj   +1 more source

Derivation of Highly Predictive 3D-QSAR Models for hERG Channel Blockers Based on the Quantum Artificial Neural Network Algorithm. [PDF]

Pharmaceuticals (Basel), 2023
Kim T, Chung KC, Park H.
europepmc   +1 more source

Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. [PDF]

, 2002
KCNE genes encode single transmembrane-domain subunits, the MinK-related peptides (MiRPs), which assemble with pore-forming alpha subunits to establish the attributes of potassium channels in vivo.
Abbott, Geoffrey W, Goldstein, Steve AN
core   +1 more source

Hysteretic hERG channel gating current recorded at physiological temperature. [PDF]

Sci Rep, 2022
Jones DK.
europepmc   +1 more source

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

PLoS ONE, 2019
The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines.
Damodara Reddy Vaddi, Lin Piao, Shakil A Khan, Ning Wang, Nanduri R Prabhakar, Jayasri Nanduri   +5 more
doaj   +1 more source