Results 91 to 100 of about 17,722 (214)
Natural products modulating the hERG channel: heartaches and hope.
Nat Prod Rep, 2017 This review covers natural products modulating the hERG potassium channel. Risk assessment strategies, structural features of blockers, and the duality target/antitarget are discussed.
Kratz JM +4 more
europepmc +6 more sources
Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. [PDF]
, 1998 A new superfamily of K+ channels has emerged in the past 2 years. Notable for possessing two pore-forming P domains in each subunit, members of the superfamily have been recognized through phylogeny from micro-organisms to humans. Four subfamilies of two
Goldstein, SA +3 more
core
A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV
Archiv der Pharmazie, Volume 359, Issue 4, April 2026.This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite +11 more
wiley +1 more source
Effects of cariprazine on hERG 1A and hERG 1A/3.1 potassium channels
European Journal of Pharmacology, 2019 Cariprazine is a novel atypical antipsychotic drug that is widely used for the treatment of schizophrenia and bipolar mania/mixed disorder. We used the whole-cell patch-clamp technique to investigate the effects of cariprazine on hERG channels that are stably expressed in HEK cells. Cariprazine inhibited the hERG 1A and hERG 1A/3.1 tail currents at -50
Hong Joon, Lee +3 more
openaire +2 more sources
, 2014 The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC)mutations by nonsense-mediatedmRNA decay (NMD) is an importantmechanismof long QT syndrome type 2 (LQT2).
Gong, Qiuming +2 more
core +1 more source
QTc Interval Prolongation and Associated Drug Therapy in Hospitalized Older Adults
Journal of the American Geriatrics Society, EarlyView.
Francesco Fantin +7 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.The graphical abstract illustrates the flowchart for the isolation and evaluation of bioactive compounds from Hedychium coronarium. Crude extracts were obtained via cold percolation from the aerial parts (flowers, leaves, and stems) using dichloromethane (DCM) and from the rhizomes using chloroform.
Riddhiman Lahiri +10 more
wiley +1 more source
HERG Protein Plays a Role in Moxifloxacin-Induced Hypoglycemia
Journal of Diabetes Research, 2016 The purpose of this study was to investigate the effect of moxifloxacin on HERG channel protein and glucose metabolism. HERG expression was investigated using immunohistochemistry.
Hai-Yan Qiu +4 more
doaj +1 more source
Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]
, 2019 As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M +2 more
core +1 more source
Drug Development Research, Volume 87, Issue 2, April 2026.ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu +7 more
wiley +1 more source