Results 41 to 50 of about 183,086 (327)

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Activation of Insula-Accumbal Projection Neurons Is Required for Relapse-Like Behaviour Following Opioid Self-Administration. [PDF]

Addict Biol
ABSTRACT The insular cortex (IC) is known to underlie drug seeking and relapse for multiple drug classes, yet the precise role the IC plays in opioid use disorder (OUD) remains unclear. In preclinical models of OUD, inhibition of the IC has produced conflicting results, such that in some cases the IC seems to promote opioid seeking whereas in others ...
Clarke RE, Pagoota BE, Dinu IE, Paniccia JE, Tsyrulnikov AC, Westphal AM, Baek J, Scofield MD, Otis JM.   +8 more
europepmc   +2 more sources

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

Gender and Age Effects on the Trajectory of Depression in Opioid Users during Methadone Maintenance Treatment

Frontiers in Psychiatry, 2017
IntroductionBoth heroin use and depression are significant health problems. Methadone maintenance treatment (MMT) can be of great benefit to heroin users. However, changes in the level of depression in heroin users during MMT are not clear.
Peng-Wei Wang, Peng-Wei Wang, Huang-Chi Lin, Huang-Chi Lin, Yi-Hsin Connie Yang, Chih-Yao Hsu, Kuan-Sheng Chung, Hung-Chi Wu, Cheng-Fang Yen, Cheng-Fang Yen   +9 more
doaj   +1 more source

The newer opioid agonist treatment with lower substitutive opiate doses is associated with better toxicology outcome than the older harm reduction treatment [PDF]

, 2016
Background: Charge-free heroin use disorder treatment in Italy follows two main approaches, i.e., harm reduction treatment (HRT) strategy in community low-threshold facilities for drug addiction and opioid agonist treatment (OAT) in high-threshold ...
Bacciardi, Silvia, Bizzarri, Jacopo V., Casetti, Valentina, Conca, Andreas, Giovanni Icro Maremmani, Angelo, Maremmani, Icro, Piacentino, Daria, Rovai, Luca, Sanna, Livia   +8 more
core   +1 more source

Psychoactive prescription drug use and misuse in patients on opioid agonist treatment

British Journal of Clinical Pharmacology, EarlyView.
Aims To identify the patterns and trends in prescription drug use and misuse in patients on opioid agonist treatment. Methods We used data from the OPPIDUM programme, which collects data from patients attending substance abuse treatment facilities. Data collected include use of psychoactive prescription drugs in the past week.
Thomas Soeiro, Clémence Lacroix, Élisabeth Jouve, Élisabeth Frauger, Maryse Lapeyre‐Mestre, Joëlle Micallef   +5 more
wiley   +1 more source

HCV and HIV infection among heroin addicts in methadone maintenance treatment (MMT) and not in MMT in Changsha and Wuhan, China. [PDF]

PLoS ONE, 2012
OBJECTIVE: To compare HCV and HIV infection among heroin addicts in MMT and not in MMT in two large cities in central China. METHODS: A total of 541 heroin addicts were recruited from MMT clinics and voluntary detoxification centers in Changsha and Wuhan,
Xuyi Wang, Linxiang Tan, Yi Li, Yao Zhang, Dongyi Zhou, Tieqiao Liu, Wei Hao   +6 more
doaj   +1 more source

Analysis of rapid onset heroin overdose cases from a supervised injecting facility in Melbourne, Australia. [PDF]

Addiction
Abstract Aims To characterise the clinical condition of rapid onset heroin overdose cases, and to determine the incidence and characteristics of such cases. Design A retrospective cohort study of witnessed heroin overdose cases over a 12‐month period (1 July 2023 to 30 June 2024). Setting The Medically Supervised Injecting Room in Melbourne, Australia.
Stam NC, Shrestha M, Tas B, Furler J, Bonomo Y, Strang J.   +5 more
europepmc   +2 more sources

The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) project: An open-label pragmatic randomised control trial comparing the efficacy of differing therapeutic agents for primary care detoxification from either street heroin or methadone [ISRCTN07752728] [PDF]

, 2004
BACKGROUND: Heroin is a synthetic opioid with an extensive illicit market leading to large numbers of people becoming addicted. Heroin users often present to community treatment services requesting detoxification and in the UK various agents are used ...
A Ritter, Advisory Council on the Misuse of Drugs, AH Masson, AK Nigam, Charlotte NE Tompkins, Clive E Adams, E Goddard, Great Britain Department of Health, Great Britain Government Statistical Service, Home Office, J Lowinson, J Strang, J Strang, L San, Laura Sheard, LJ Cheskin, M Ramsay, N Linteris, N Seivewright, Nat MJ Wright, Nicola S Oldham, PG O'Connor, Royal Pharmaceutical Society of Great Britain, WK Bickel   +22 more
core   +3 more sources