Results 51 to 60 of about 135,764 (330)

A Discrete-time Networked Competitive Bivirus SIS Model [PDF]

arXiv, 2023
The paper deals with the analysis of a discrete-time networked competitive bivirus susceptible-infected-susceptible (SIS) model. More specifically, we suppose that virus 1 and virus 2 are circulating in the population and are in competition with each other.
arxiv  

Deep‐Learning Model for Central Nervous System Infection Diagnosis and Prognosis Using Label‐Free 3D Immune‐Cell Morphology in the Cerebrospinal Fluid

Advanced Intelligent Systems, EarlyView.
Early diagnosis and prognosis prediction of central nervous system infections are critical. This study introduces a deep‐learning model utilizing cerebrospinal fluid immune‐cell morphology captured via 3D holotomography. The model effectively predicts infection etiology and prognosis, achieving high accuracy.
Bo Kyu Choi, Ho Heon Yang, Jong Hyun Kim, JaeSeong Hong, Kyung Min Kim, Yu Rang Park   +5 more
wiley   +1 more source

A little less aggregation a little more replication: Viral manipulation of stress granules

WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023
Viruses depend entirely on host machinery and therefore aim to conquer the host and defeat its defenses to co‐opt its resources for its own replication. Improved understanding of how viruses counteract host immune responses such as stress granule assembly, detailed here, will inform future antiviral therapeutic strategies.
Matthew J. Brownsword, Nicolas Locker
wiley   +1 more source

Herpes simplex type 1 pneumonitis and acute respiratory distress syndrome in a patient with chronic lymphatic leukemia: a case report

Journal of Medical Case Reports, 2017
Background Pulmonary pathogenicity of herpes simplex virus type 1 in patients in intensive care without classic immunosuppression as well as the necessity of antiviral treatment in the case of herpes simplex virus detection in respiratory specimens in ...
Miriam Luginbuehl, Alexander Imhof, Alexander Klarer   +2 more
doaj   +1 more source

Severe diabetic ketoacidosis triggered by concomitant central nervous system and genital Herpes Simplex Virus type 2 infection.

Medicina Universitaria, 2022
Diabetic ketoacidosis is a life-threatening acute complication of type-1 diabetes mellitus. It is most frequently precipitated by bacterial infections, although viral pathogens should always be considered.
Victoria A. Ahuett-Lopez, Santiago E. Gonzalez-Davila, Mª Alejandra Garza-Ledezma, Sergio A. Castillo-Torres   +3 more
doaj   +1 more source

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey, Liam Gaziano, Preethi Eldi, Catherine Toben, Beben Benyamin, S. Hong Lee, Elina Hyppönen   +6 more
wiley   +1 more source

Fusion of the β2‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells

FASEB BioAdvances, Volume 4, Issue 12, Page 758-774, December 2022., 2022
Abstract The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway.
Emilio Y. Lucero‐Garcia Rojas, Arfaxad Reyes‐Alcaraz, Kehe Ruan, Bradley K. McConnell, Richard A. Bond   +4 more
wiley   +1 more source

RNA interference inhibits herpes simplex virus type 1 isolated from saliva samples and mucocutaneous lesions

Brazilian Journal of Infectious Diseases, 2014
The aim of this study was to evaluate the use of RNA interference to inhibit herpes simplex virus type-1 replication in vitro. For herpes simplex virus type-1 gene silencing, three different small interfering RNAs (siRNAs) targeting the herpes simplex ...
Amanda Perse da Silva, Juliana Freitas Lopes, Vanessa Salete de Paula   +2 more
doaj  

Harringtonine Inhibits Herpes Simplex Virus Type 1 Infection by Reducing Herpes Virus Entry Mediator Expression

Frontiers in Microbiology, 2021
Herpes simplex virus type 1 (HSV-1) infection induces various clinical disorders, such as herpes simplex encephalitis (HSE), herpes simplex keratitis (HSK), and genital herpes.
Ye Liu, Ye Liu, Qiao You, Fang Zhang, Deyan Chen, Zhenping Huang, Zhiwei Wu, Zhiwei Wu, Zhiwei Wu   +8 more
doaj   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source