Results 61 to 70 of about 135,764 (330)

Self-organized critical dynamics of RNA virus evolution [PDF]

arXiv, 2022
RNA virus (e.g., SARS-CoV-2) evolves in a complex manner. Studying RNA virus evolution is vital for understanding molecular evolution and medicine development. Scientists lack, however, general frameworks to characterize the dynamics of RNA virus evolution directly from empirical data and identify potential physical laws. To fill this gap, we present a
arxiv  

Identification of the Micro‐Ribonucleic Acid Profiles of Plant‐Derived Extracellular Vesicles and their Potential Crosskingdom Regulation

Advanced NanoBiomed Research, EarlyView.
The present study employs small RNA sequencing to identify the types and content of microRNAs (miRNAs) in four widely utilized plant‐derived extracellular vesicles (pEVs). The functional annotation reveals that the pEV miRNAs are involved in regulating the progression of human cancer and viral infection, thereby demonstrating the crosskingdom ...
Fei Wang, Junyao Deng, Shushan Mo, Jiacong Ai, Yingxian Xiao, Xiaohan Zhou, Zhenhua Li, Lanya Li   +7 more
wiley   +1 more source

Phase-Transitions in a model for the formation of herpes simplex ulcers [PDF]

arXiv, 2001
The critical properties of a cellular automaton model describing the spreading of infection of the Herpes Simplex Virus in corneal tissue are investigated through the dynamic Monte Carlo method. The model takes into account different cell susceptibilities to the viral infection, as suggested by experimental findings. In a two-dimensional square lattice,
arxiv  

Genome‐Wide Aggregated Trans Effects Analysis Identifies Genes Encoding Immune Checkpoints as Core Genes for Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes.
Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Megan Sutcliffe, Seema Sharma, Cankut Cubuk, Myles Lewis, Costantino Pitzalis, Anne Barton, Paul M. McKeigue   +9 more
wiley   +1 more source

Modified contact simplex iteration [PDF]

arXiv, 2021
We study the iterations of the procedure of taking the contact simplex. We define the concept of the root of the simplex, which is a homothety image of contact simplex with a special coefficient greater than 1. The article shows that once we iterate the root of a given simplex, the circumcenter sequence of these simplices has two partial limits.
arxiv  

A synthetic platform for developing recombinant adeno‐associated virus type 8 producer cell lines

Biotechnology Progress, EarlyView.
Abstract Recombinant adeno‐associated virus (rAAV) is one of the most widely used viral vectors for gene therapy. It is used in very high doses for the treatment of many diseases, making large‐scale production for clinical applications challenging. We have established a synthetic biology‐based platform to construct stable production cell lines, which ...
Yu‐Chieh Lin, Han‐Jung Kuo, Min Lu, Thomas Mahl, George Aslanidi, Wei‐Shou Hu   +5 more
wiley   +1 more source

Aβ plaques do not protect against HSV‐1 infection in a mouse model of familial Alzheimer's disease, and HSV‐1 does not induce Aβ pathology in a model of late onset Alzheimer's disease

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
Abstract The possibility that the etiology of late onset Alzheimer's disease is linked to viral infections of the CNS has been actively debated in recent years. According to the antiviral protection hypothesis, viral pathogens trigger aggregation of Aβ peptides that are produced as a defense mechanism in response to infection to entrap and neutralize ...
Olga V. Bocharova, Aidan Fisher, Narayan P. Pandit, Kara Molesworth, Olga Mychko, Alison J. Scott, Natallia Makarava, Rodney Ritzel, Ilia V. Baskakov   +8 more
wiley   +1 more source

SARS-CoV-2 Virus-Like Particles with Plasmonic Au Cores and S1-Spike Protein Coronas [PDF]

arXiv, 2022
The COVID-19 pandemic has stimulated the scientific world to intensify virus-related studies, aimed at the development of quick and safe ways of detecting viruses in human body, studying the virus-antibody and virus-cell interactions, and designing nanocarriers for targeted antiviral therapies.
arxiv  

Chemical composition, antioxidant, antimicrobial, antidiabetic and butyrylcholinesterase inhibitory activities in vitro of the essential oil and crude extracts of the aerial parts of Thymus ciliatus

Chemistry &Biodiversity, Accepted Article.
This study explores the potential of Thymus ciliatus as a natural source of bioactive compounds by investigating its chemical composition and in vitro biological activities, including antioxidant, antimicrobial, antidiabetic, and anti‐Alzheimer properties. The analysis of the essential oil was performed using GC‐MS revealing α‐terpinenyl acetate (18.74%
Nadia Djermane, Mostapha Brahmi, Djallal Eddine Adli, Micaela Gliozzi, Vincenzo Musolino, Rebbas Khellaf, Ramazan Erenler, Rabah Arhab, Stefania Garzoli   +8 more
wiley   +1 more source

Optimal management of genital herpes: current perspectives

Infection and Drug Resistance, 2016
Andreas Sauerbrei Institute of Virology and Antiviral Therapy, German Consulting Laboratory for Herpes Simplex Virus and Varicella-Zoster Virus, Jena University Hospital, Friedrich-Schiller University of Jena, Jena, Germany Abstract: As one of the most ...
Sauerbrei A
doaj