Results 71 to 80 of about 317,155 (257)

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Inhibitory effect of silver nanoparticles on bovine herpesvirus-1

International Journal of Veterinary Science and Medicine, 2018
Currently available antiviral drugs have certain limitations. Therefore, silver nanoparticles (Ag-NPs) have recently received an increasing attention with respect to their antibacterial and antiviral properties.
R. El-Mohamady, T. Ghattas, M. Zawrah, Y.G.M. Abd El-Hafeiz   +3 more
semanticscholar   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, EarlyView.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Simultaneous detection of bovine viral diarrhea virus (BVDV) and bovine herpesvirus 1 (BoHV-1) using recombinase polymerase amplification

Scientific Reports
Bovine viral diarrhea virus (BVDV) is considered to be the most common agent of severe diarrhea in cattle worldwide, causing fever, diarrhea, ulcers, and abortion.
Lingling Jiang, Gang Zhang, Pu Wang, Xiaoxia Niu, Qiang Liu, Sinong Zhang, Weifeng Gao, Yong Li   +7 more
semanticscholar   +1 more source

Vaccination Reduces Shedding of Salmonid Alphavirus Subtype 3, but Bacterial Co‐Infection Influences the Effect

Journal of Fish Diseases, EarlyView.
ABSTRACT Waterborne horizontal transmission of viral diseases in fish relies on the release of infectious virus particles (termed shedding) into the aquatic environment. Both the rate and duration of shedding are critical for efficient viral spread, making interventions that reduce shedding valuable for disease control.
Søren Grove, H. Craig Morton, Dhamotharan Kannimuthu, HyeongJin Roh, Ravikumar M. Chovatia, Ma Michelle Peñaranda, Dawit Ghebretnsae, Kai Ove Skaftnesmo   +7 more
wiley   +1 more source

The biology and development of vaccines for bovine herpesvirus 1.

The Veterinary Journal
Bovine herpesvirus type 1 (BoAHV-1) infections lead to compromised herd health and significantly reduced productivity of affected cattle. While BoAHV-1 may cause rhinotracheitis, conjunctivitis, genital infections, and abortions, respiratory tract ...
Akshaya Krishnagopal, S. V. D. Littel-van den Hurk   +1 more
semanticscholar   +1 more source

Immune dysregulation in mania: A proof‐of‐concept platelet proteomics study

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Bipolar disorder (BD) is a major psychiatric condition with a multifaceted and largely unknown pathophysiology. Mania, the defining feature of BD, remains underinvestigated. Proteomics offers a powerful, data‐driven, unbiased approach to uncover biological alterations.
Paola Magioncalda, Matteo Martino, Nhi Thao Ngoc Le, Wen‐Yin Chen, Ming‐Chyi Huang, David Blum, Thierry Burnouf   +6 more
wiley   +1 more source

Investigations of presence of antibodies against bovine herpesvirus-1 in blood serum of calves prior to colostrum diet [PDF]

Veterinarski Glasnik, 2010
The paper presents the results of investigations of the presence of the bovine herpesvirus-1 (BHV-1) in samples of blood serum from 106 cows and 107 of their calves (one cow had twins).
Lazić Sava, Rogan Dragan, Petrović Tamaš, Bugarski Dejan, Lupulović Diana, Lazarević Miodrag   +5 more
doaj   +1 more source

Bovine Herpesvirus 1 Entry by a Low-pH Endosomal Pathway

Journal of Virology, 2018
BoHV-1 is a ubiquitous pathogen affecting cattle populations worldwide. Infection can result in complicated, polymicrobial infections due to the immunosuppressive properties of the virus.
G. Pastenkos, Becky H. Lee, S. Pritchard, A. Nicola   +3 more
semanticscholar   +1 more source