Results 41 to 50 of about 6,792 (174)

Gastrointestinal absorption and metabolism of hesperetin‐7‐O‐rutinoside and hesperetin‐7‐O‐glucoside in healthy humans

Molecular Nutrition & Food Research, 2015
ScopeHesperetin‐7‐O‐rutinoside (hesperidin) reduces blood pressure in healthy volunteers but its intestinal absorption and metabolism are not fully understood. Therefore, we aimed to determine sites of absorption and metabolism of dietary flavanone glycosides in humans.Methods and resultsUsing a single‐blind, randomized crossover design, we perfused ...
Actis-Goretta, L., Dew, T.P., Leveques, A., Pereira-Caro, G., Rein, M., Teml, A., Schaefer, C., Hofmann, U., Schwab, M., Eichelbaum, M., Crozier, A., Williamson, G.   +11 more
openaire   +4 more sources

Valorization of fruit pits from Prunus laurocerasus and Prunus cerasifera as agro‐food byproducts: Bioactive properties and safety assessment for potential food additive applications

Journal of the Science of Food and Agriculture, Volume 106, Issue 10, Page 6002-6014, 15 August 2026.
Abstract BACKGROUND Food additives are widely used to extend the shelf life of foods and maintain their quality. In this study, the potential of Prunus laurocerasus and Prunus cerasifera fruit pits (endocarp and seed) as food additives was investigated in terms of cytotoxicity, antigenotoxicity, antioxidant activity, enzymatic anti‐browning, and urease
Zühal Bayrakçeken Güven, Mehmet Karadayı, Mustafa Abdullah Yilmaz, Osman Tugay, Oguz Cakir   +4 more
wiley   +1 more source

Anticonvulsant effects of hesperetin in animal model of pentylenetetrazole-induced-seizures

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2018
Background and objective: Hesperetin as the main flavonoid in citrus possesses various pharmacological properties including anti-oxidant and anti-inflammatory effects.
S Baradaran, M Ghasemi-Kasman, A Ebrahimpour, SR Ahmadian, M Pouramir   +4 more
doaj  

Ultra‐High‐Throughput Discovery of Multifunctional Polyphenolic Coatings on Droplet Microarrays

Advanced Materials, Volume 38, Issue 39, 13 July 2026.
An ultra‐high‐throughput (UHT) combinatorial strategy enables the miniaturized synthesis and screening of ≈30 000 polyamine‐polyphenolic (PaPp) coatings using droplet microarrays (DMA). This approach reveals hundreds of previously unknown fluorescent, redox‐active, and antibacterial materials, including multifunctional, cell‐compatible surfaces ...
Vania Tanda Widyaya, Joaquín E. Urrutia Gómez, Paul Reuß, Alexander Welle, Rolf A. Gattung, Jana Mayer, Peter Krolla, Markus Reischl, Pascal Friederich, Anna A. Popova, Thomas Schwartz, Pavel A. Levkin   +11 more
wiley   +1 more source

Hesperetin attenuates ischemia/reperfusion-induced acute kidney injury by regulating ferroptosis in mice

Renal Failure
Background Acute kidney injury (AKI) is a complex syndrome often resulting from ischemia/reperfusion (I/R) injury (IRI). Due to the significant role of ferroptosis in AKI pathogenesis, therapeutic strategies targeting ferroptosis could offer potential ...
Xiaoyu Xie, Chen Guan, Ningxin Zhang, Chenyu Li, Zengying Liu, Chengyu Yang, Liting Wang, Yan Xu   +7 more
doaj   +1 more source

The Effect of Component of Cream for Topical Delivery of Hesperetin

Chemical and Pharmaceutical Bulletin, 2010
The aim of this study was to optimize hesperetin cream formulations by in vitro permeation study and evaluate topical whitening active effect and skin irritation by in vivo study. The results showed that the solubility of lipophilic compound of hesperetin was increased by short-chain alcohol including ethanol, glycerin, propylene glycol and ...
Huang, Yaw-Bin, Lee, Ko-Feng, Huang, Chi-Te, Tsai, Yi-Hung, Wu, Pao-Chu   +4 more
openaire   +3 more sources

Comprehensive Phenolic Profiling and Antioxidant Evaluation of Calyx, Rind, and Edible Tissues From Non‐Astringent Persimmons (Diospyros kaki)

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Tissue‐specific phenolic profiling of non‐astringent persimmons (Fuyu and Jiro) reveals substantial differences in phytochemical composition and antioxidant potential. Persimmon calyx exhibits the highest concentrations of bioactive compounds, highlighting its potential as a valuable by‐product for functional food and nutraceutical applications ...
Huiwen Wang, Muhammad Sajid Arshad, Ayesha Siddiqa, Malik Adil Nawaz, Hafiz A. R. Suleria   +4 more
wiley   +1 more source

Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats

Future Journal of Pharmaceutical Sciences, 2023
Background Metoprolol is a substrate of CYP3A4, 2B6, CYP2D6, CYP2C9, and p-glycoprotein (p-gp). Hesperetin was reported as an inhibitor of cytochrome P-450 (CYP) enzymes and p-gp. The objective of this study was to investigate the effect of hesperetin on
Ravindra Babu Pingili, Sridhar Vemulapalli, Surya Sandeep Mullapudi, Vijaya R. Dirisala, Harsha Sai Chanumolu, Naveen Babu Kilaru   +5 more
doaj   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Anti-Sindbis Activity of Flavanones Hesperetin and Naringenin.

Biological and Pharmaceutical Bulletin, 2003
The effect of hesperetin, naringenin and its glycoside form on the Sindbis neurovirulent strain (NSV) replication in vitro was studied. All flavanones tested were not cytotoxic on Baby Hamster cells 21 clone 15 (BHK-21). Antiviral effect was evaluated by a colorimetric assay using MTT (3-(4,5 dimethylthiazol-2-yl)-2,5-dipheyl-tetrazolium bromide) and ...
Paredes, Adriana, Alzuru, Maríaelena, Mendez, Jeannette, Rodríguez-Ortega, Morella   +3 more
openaire   +3 more sources