Results 21 to 30 of about 6,792 (174)
Frontiers in Pharmacology, 2020 As one of the most common malignant gastrointestinal tumors, gastric cancer (GC) has a high incidence and poor prognosis. Cisplatin (DDP) is often used as chemotherapy for advanced GC; however, the high incidence of drug resistance remains a problem. The
Pengzhan He +10 more
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Hesperetin, a potential therapy for carcinoid cancer [PDF]
The American Journal of Surgery, 2011 The investigators' laboratory has demonstrated that the Notch1 signaling pathway acts as a tumor suppressor in carcinoid tumors. The aim of this study was to examine hesperetin, a flavonoid, as a potential Notch1 activator and carcinoid tumor suppressor.A high-throughput drug screen revealed hesperetin as a Notch1 activator.
Barbara, Zarebczan +3 more
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Hesperetin attenuates the expression of markers of adipose tissue fibrosis in pre-adipocytes
BMC Complementary Medicine and Therapies, 2023 Background Excessive extracellular matrix (ECM) deposition in adipose tissue is a hallmark of fibrosis, leading to disrupted adipose tissue homeostasis and metabolic dysfunction.
Alemeh Taheri +6 more
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Frontiers in Pharmacology, 2023 Hesperetin is a natural flavonoid with many biological activities. In view of hyperuricemia treatment, the effects of hesperetin in vivo and in vitro, and the underlying mechanisms, were explored.
Meng-Fei An +21 more
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IUCrJ, 2023 Hesperetin (HES) is a weakly acidic flavonoid of topical interest owing to its antiviral properties. Despite the presence of HES in many dietary supplements, its bioavailability is hindered by poor aqueous solubility (1.35 µg ml−1) and rapid first-pass metabolism.
Shasha Jin +4 more
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Validation of RP-HPLC Method for Simultaneous Quantification of Bicalutamide and Hesperetin in Polycaprolactone-Bicalutamide-Hesperetin-Chitosan Nanoparticles [PDF]
Journal of Chromatographic Science, 2015 Bicalutamide is a non-steroidal anti-androgen drug used for the treatment of androgen-dependent prostate cancer. Hesperetin is a natural bioflavonoid that can be used in combination with bicalutamide to improve efficacy and decrease tolerance. The aim of the present work was to develop and validate a simple, sensitive, rapid reverse phase-high ...
Abhishek, Arya +7 more
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Foods, 2023 The aim of this research was to investigate the antimicrobial characteristics and mechanism of hesperetin against Alicyclobacillus acidoterrestris vegetative cells.
Siqi Zhao +6 more
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Food Safety and Health, EarlyView.Fenugreek and stevia extracts protect against dexamethasone‐induced testicular damage in male rats by enhancing antioxidant defenses, improving sperm quality, and restoring hormonal balance, highlighting their potential as natural therapeutics for preventing corticosteroid‐induced reproductive toxicity.
Mosab Gad +3 more
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Synthesis, characterization, and evaluation of Hesperetin nanocrystals for regenerative dentistry
Scientific Reports, 2023 Hesperetin (HS), a metabolite of hesperidin, is a polyphenolic component of citrus fruits. This ingredient has a potential role in bone strength and the osteogenic differentiation.
Mahdieh Alipour +5 more
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Jurnal Kedokteran Hewan, 2021 Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels.
Nerdy Nerdy +7 more
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