Results 1 to 10 of about 6,772 (154)

A Comparative Study of Hesperetin, Hesperidin and Hesperidin Glucoside: Antioxidant, Anti-Inflammatory, and Antibacterial Activities In Vitro

Antioxidants, 2022
The antioxidant, anti-inflammatory and antibacterial activities of hesperetin, hesperidin and hesperidin glucoside with different solubility were compared in vitro. Hesperetin was prepared by enzymatic hydrolysis from hesperidin, and hesperidin glucoside
Kyung-Ae Lee
exaly   +3 more sources

Therapeutic Effects of Hesperetin and Nano Hesperetin on Ketamine-Induced Hepatotoxicity

Journal of Medicinal Plants, 2019
Background: Ketamine (KET) causes oxidative stress and liver damage. Hesperetin plays an important role in the prevention of inflammatory processes and associated with oxidative stress.
A Hajizadeh Moghadam, M Parhizkar, R Sirafi, S Khanjani Jelodar   +3 more
doaj   +3 more sources

Mechanisms of hesperetin in alleviating diabetic nephropathy: Network pharmacology, molecular docking, and experimental validation [PDF]

Journal of Diabetes Investigation
Background Diabetic nephropathy (DN) accounts for approximately 50% of chronic kidney disease cases. This study explored the potential regulatory mechanisms of hesperetin in DN.
Yiwen Guo, Fengjiao Zhang, Yu Jin, Menglu Zhu, Zhiqiang Kang   +4 more
doaj   +2 more sources

Hesperetin reduces neuronal death in an SHSY5Y Alzheimer’s model by inhibiting inflammation and apoptosis and pyroptosis cell death pathways [PDF]

Scientific Reports
Alzheimer’s disease (AD) features amyloid-β (Aβ)1–42 plaques, neuroinflammation, and neuronal loss. Apoptosis and pyroptosis contribute to AD, with inflammatory cytokines involved.
Leila Shafiee, Maryam Sadat Pishva, Rosa Hosseinzadegsn, Zahra Bahadori, Payam Baziyar, Mahtab Mehboodi, Samereh Khademee, Mohammadarian Akbari, Mahsa Motamed, Elham Nadimi   +9 more
doaj   +2 more sources

The protective effect of hesperetin and nano-hesperetin on object recognition memory in animal model of Alzheimer [PDF]

Research Journal of Pharmacognosy, 2017
Background and objectives: Hesperetin (Hst), aglycone form of hesperidin, is reported to have antioxidant, anti-inflammatory and neuroprotective activities.
doaj   +1 more source

Possible applicability of flavonoid hesperetin for the treatment of dental biofilm-forming Candida glabrata [PDF]

Journal of Oral Biology and Craniofacial Research
Background: Biofilm formation is a key virulence factor for Candida glabrata because it forms an extracellular matrix that prevents antifungal passage, which resists antifungal agents and causes treatment failure.
Bhavesh Sureendar, Vinothini Gunasekaran, Dhanraj Ganapathy, Palanivel Sathishkumar   +3 more
doaj   +2 more sources

Activation of CISD2 as a protective strategy against doxorubicin-induced cardiotoxicity [PDF]

Redox Biology
Background: Cardiotoxicity of doxorubicin, a chemotherapy medication, remains the most dangerous side effect. CISD2 plays a critical role during cardiac aging.
Yi-Ju Chou, Chi-Hsiao Yeh, Chian-Feng Chen, Chi-Jen Lo, Jian-Hsin Yang, Wen-Tai Chiu, Cheng-Heng Kao, Tsai-Yu Tzeng, Zhao-Qing Shen, Chien-Yi Tung, Chung-Kuang Lu, Mei-Ling Cheng, Patrick C.H. Hsieh, Shu-Ling Fu, Ting-Fen Tsai   +14 more
doaj   +2 more sources

Bioinformatics and In Vitro Studies Reveal the Importance of p53, PPARG and Notch Signaling Pathway in Inhibition of Breast Cancer Stem Cells by Hesperetin [PDF]

Advanced Pharmaceutical Bulletin, 2021
Purpose: The failure of chemotherapy in breast cancer is caused by breast cancer stem cells (BCSCs), a minor population of cells in bulk mammary tumors. Previously, hesperetin, a citrus flavonoid, showed cytotoxicity in several cancer cells and increased
Adam Hermawan, Muthi Ikawati, Annisa Khumaira, Herwandhani Putri, Riris Istighfari Jenie, Sonia Meta Angraini, Haruma Anggraini Muflikhasari   +6 more
doaj   +1 more source

Antioxidant, Antiapoptotic, and Anti-Inflammatory Effects of Hesperetin in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury

Molecules, 2023
Sepsis is a severe inflammatory condition that can cause organ dysfunction, including acute kidney injury (AKI). Hesperetin is a flavonoid aglycone that has potent antioxidant and anti-inflammatory properties.
Ah Young Yang, Hye Jin Choi, Kiryeong Kim, Jaechan Leem   +3 more
doaj   +1 more source

Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease

Antioxidants, 2022
Background: No effective therapeutic agents for calcific aortic valve disease (CAVD) are available currently. Dietary supplementation has been proposed as a novel treatment modality for various diseases.
Hengli Zhao, Gaopeng Xian, Jingxin Zeng, Guoheng Zhong, Dongqi An, You Peng, Dongtu Hu, Yingwen Lin, Juncong Li, Shuwen Su, Yunshan Ning, Dingli Xu, Qingchun Zeng   +12 more
doaj   +1 more source