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Hesperetin Liposomes for Cancer Therapy [PDF]
Current Drug Delivery, 2016 Hesperetin is a compound from citrus fruit that has previously been found to exert anticancer activity through a variety of mechanisms. However, the application of hesperetin to cancer therapy has been hampered by its hydrophobicity, necessitating the use of toxic solubilizing agents. Here, we have developed the first liposome-based delivery system for
Wolfram, Joy +11 more
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Foods, 2023 The inhibitory activity of hesperetin on polyphenol oxidase (PPO) and their interaction characteristics were investigated using multiple spectroscopic methods and computational simulation. Hesperetin, a mixed inhibitor, reversibly inhibited PPO activity,
Xinyue Hong +4 more
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Hesperetin alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of periodontal ligament stem cells. [PDF]
PLoS ONE, 2013 Hesperetin (3',5,7-trihydroxy-4-methoxyflavanone) is a metabolite of hesperidin (hesperetin-7-O-rutinoside), which belongs to the flavanone subgroup and is found mainly in citrus fruits.
So Yeon Kim +5 more
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Advances in Cancer Biology - Metastasis, 2022 Prostate cancer is the most prevalent cancer in males, and usually, death occurs due to bone metastasis. TGFβ has been shown to play an essential role in the metastasis of prostate cancer cells by promoting epithelial-to-mesenchymal transition (EMT ...
Nidhi Dalpatraj +3 more
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Solubility of Hesperetin in Mixed Solvents [PDF]
Journal of Chemical & Engineering Data, 2013 The study of the solubility of important biomolecules such as flavonoids is essential to support the design of several separation processes in the food and pharmaceutical industries. Following our previous studies, new solubility data of hesperetin in the mixed solvents water + acetone, water + ethanol, and water + methanol were measured, at 298.2 K ...
Ferreira, Olga +2 more
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Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice
Journal of Biomedical Science, 2022 Background The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse lifespan and healthspan.
Chi-Hsiao Yeh +7 more
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Current Issues in Molecular Biology, 2023 Background: Hesperetin has been reported to have anticancer properties. However, the molecular mechanisms underlying its action on leukemia cells remain unclear. This in vitro study evaluated the possible mechanisms of hesperetin in leukemia cells (HL-60
Ching-Yeh Lin +2 more
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Conformational Trimorphism in an Ionic Cocrystal of Hesperetin
Crystal Growth & Design, 2022 We report the existence of conformational polymorphism in an ionic cocrystal (ICC) of the nutraceutical compound hesperetin (HES) in which its tetraethylammonium (TEA+) salt serves as a coformer. Three polymorphs, HESTEA-α, HESTEA-β and HESTEA-γ, were characterized by single-crystal X-ray diffraction (SCXRD). Each polymorph was found to be sustained by
Shasha Jin +5 more
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Hesperetin—Between the Ability to Diminish Mono- and Polymicrobial Biofilms and Toxicity
Molecules, 2022 Hesperetin is the aglycone of citrus flavonoid hesperidin. Due to the limited information regarding hesperetin antimicrobial potential and emerging need for novel antimicrobials, we have studied its antimicrobial activity (microdilution assay ...
Tamara Carević +5 more
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Molecules, 2021 In the present study, we investigated the structure-activity relationship of naturally occurring hesperetin derivatives, as well as the effects of their glycosylation on the inhibition of diabetes-related enzyme systems, protein tyrosine phosphatase 1B ...
Md Yousof Ali +3 more
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