Results 151 to 160 of about 102,384 (311)

A heterochromatin-dependent transcription machinery drives piRNA expression

Nature, 2017
Nuclear small RNA pathways safeguard genome integrity by establishing transcription-repressing heterochromatin at transposable elements. This inevitably also targets the transposon-rich source loci of the small RNAs themselves.
Peter R Andersen, László Tirián, Milica Vunjak, J. Brennecke   +3 more
semanticscholar   +1 more source

The YETI gene: from Drosophila melanogaster heterochromatin to human craniofacial development.

, 2011
In the present work, we have performed a functional analysis of CG40218, a heterochromatin gene encoding the YETI protein. YETI is a member of the evolutionarily conserved family of BCNT proteins whose function is still unclear.
F. R. Mariotti, PIACENTINI, Lucia, DIMITRI, Patrizio, E. Damia, FANTI, Laura, R. Moschetti, ROSSI, FABRIZIO, M. C. Accardo, MESSINA, GIOVANNI, E. Giordano   +9 more
core  

KMT5C‐Mediated H4K20me3 Recruits EWSR1 to Propel Clear Cell Renal Cell Carcinoma Progression via Regulating ACADM Transcription and m6A Modification

Med Research, EarlyView.
A schematic diagram illustrating the KMT5C‐H4K20me3‐EWSR1‐ACADM signaling axis and its role in ccRCC progression. Key Outcomes: KMT5C/H4K20me3 are upregulated in ccRCC and predict poor prognosis. EWSR1 is a novel noncanonical H4K20me3 reader in ccRCC. KMT5C/EWSR1 co‐repress ACADM via transcription and m6A modification. A‐196 + sunitinib synergistically
Chengjian Ji, Da Zhong, Tian Rao, Xiaojun Li, Weiyu Kong, Xi Zhang, Xiyi Wei, Bing Yao, Xinqiang Li, Ninghong Song, Chao Qin   +10 more
wiley   +1 more source

Positioning heterochromatin at the nuclear periphery suppresses histone turnover to promote epigenetic inheritance

Cell, 2019
SUMMARY In eukaryotes, heterochromatin is generally located at the nuclear periphery. This study investigates the biological significance of perinuclear positioning for heterochromatin maintenance and gene silencing.
Sahana Holla, Jothy Dhakshnamoorthy, H. Diego Folco, Vanivilasini Balachandran, Hua Xiao, L. Sun, David Wheeler, M. Zofall, Shiv I. S. Grewal   +8 more
semanticscholar   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

bioRxiv, 2019
Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the
A. Poleshko, Cheryl L. Smith, S. Nguyen, Priya Sivaramakrishnan, Karen G. Wong, J. I. Murray, M. Lakadamyali, E. Joyce, R. Jain, J. Epstein   +9 more
semanticscholar   +1 more source

Histone variant H2A.W7 represses meiotic crossover formation in Arabidopsis heterochromatin

In eukaryotic genomes, DNA is packaged into nucleosomes to form chromatin. The incorporation of canonical or variant histones into nucleosomes confers different properties and influences chromatin structure to regulate cellular processes, including ...
Zhong, Z., Henderson, I. R., Lambing, C., Liu, X., Topp, S. D., Kuo, P., Tock, A. J.   +6 more
core   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source

CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation.

PLoS Biology
The densely packed centromeric heterochromatin at minor and major satellites is comprised of H3K9me2/3 histones, the heterochromatin protein HP1α, and histone variants.
Gokul Gopinathan, Qian Xu, Xianghong Luan, Thomas G H Diekwisch   +3 more
doaj   +1 more source