Results 171 to 180 of about 124,493 (360)

Nucleolar Organization in Response to Transcriptional Stress

Cancer Science, EarlyView.
In this review, we provide an overview of the research field on nucleolar regulation, mainly focusing on nucleolar organization under transcriptional stress. We also highlight the importance of ribosomal DNA stability, particularly in disease prevention, including cancer.
Rikiya Imamura, Takaaki Yasuhara
wiley   +1 more source

MITOTIC RECOMBINATION IN THE HETEROCHROMATIN OF THE SEX CHROMOSOMES OF DROSOPHILA MELANOGASTER [PDF]

, 1978
Pedro Ripóll, Antonio Garcı́a-Bellido
openalex   +1 more source

Reorganization of H3K9me heterochromatin leads to neuronal impairment via the cascading destruction of the KDM3B-centered epigenomic network

iScience
Summary: Histone H3K9 methylated heterochromatin silences repetitive non-coding sequences and lineage-specific genes during development, but how tissue-specific genes escape from heterochromatin in differentiated cells is unclear.
Mi-Jin An, Ji-Young Kim, Jinho Kim, Dae-Hyun Kim, Geun-Seup Shin, Hyun-Min Lee, Ah-Ra Jo, Yuna Park, Yujeong Hwangbo, Chul-Hong Kim, Mi Jin Kim, Youn-Sang Jung, Jeongkyu Kim, Sangmyung Rhee, Sang-Beom Seo, Jung-Woong Kim   +15 more
doaj   +1 more source

Hypertranscription of rDNA Responsible for Nucleolar Remodelling is a Doorman for Acquiring Pluripotency

Cell Proliferation, EarlyView.
Active nucleoli have the capability to release perinuclear heterochromatin, which is a novel event of iPSC reprogramming. ABSTRACT Ribosome biogenesis occurs within the nucleolus, with the initial step being the transcription of ribosomal DNA (rDNA). Although rDNA transcription is limited in somatic cells, it is more active in stem cells. Nevertheless,
Yuchen Sun, Xinglin Hu, Xingwei Huang, Wenyao Zhou, Shubing Lan, Hui Zhang, Guangming Wu, Lei Lei   +7 more
wiley   +1 more source

Chromocentres in polymorphs as interphase markers for chromosomes having increased constitutive heterochromatin [PDF]

, 1974
Niels B. Atkin, M.C. Baker
openalex   +1 more source

Overcoming BET‐inhibitor JQ1 resistance in aggressive non‐small cell lung cancer by inducing ferroptosis via inhibition of the BRD2–FTH1 axis

The FEBS Journal, EarlyView.
Recent studies emphasize alternative functions of FTH1 relevant for nuclear processes, such as transcriptional regulation. This study shows a novel FTH1/BRD2 association in non‐small cell lung carcinoma (NSCLC). This nuclear interaction affects BRD2 protein stability in aggressive NSCLC cells.
Stefania Scicchitano, Cinzia Garofalo, Beatrice Stella, Gianluca Santamaria, Flora Cozzolino, Vittoria Monaco, Flavia Biamonte, Maria Monti, Eleonora Vecchio, Maria Concetta Faniello   +9 more
wiley   +1 more source

A bouquet-like attachment plate for telomeres in leptotene of rye revealed by heterochromatin staining [PDF]

, 1976
Julian B. Thomas, P. J. Kaltsikes
openalex   +1 more source

Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression

The FEBS Journal, EarlyView.
Genes repressed by the Polycomb system display greater chromatin folding compared to ‘regular’ inactive genes. The associated chromatin compaction, driven by PRC1‐H3K27me3 interactions, is modest and dynamic. This questions traditional models where Polycomb proteins repress transcription by sheltering genes from transcriptional activators.
Ludvig Lizana, Yuri B. Schwartz
wiley   +1 more source

A MECHANISM OF CHROMOSOMAL REARRANGEMENTS: THE ROLE OF HETEROCHROMATIN AND ECTOPIC JOINING [PDF]

, 1978
Jong Sik Yoon, R. H. Richardson
openalex   +1 more source

Phase separation drives heterochromatin domain formation

Nature, 2017
Amy R. Strom, A. Emelyanov, Mustafa Mir, D. Fyodorov, X. Darzacq, G. Karpen   +5 more
semanticscholar   +1 more source