Results 171 to 180 of about 73,923 (265)

Transcriptomic and Metabolomic Analyses in Monozygotic and Dizygotic Twins

open access: yesAmerican Journal of Medical Genetics Part A, Volume 197, Issue 4, April 2025.
ABSTRACT Monozygotic (MZ) and dizygotic (DZ) twins are studied to understand genetic and environmental influences on complex traits, however the mechanisms behind twinning are not completely understood. (Epi)genomic studies identified SNPs associated with DZ twinning and DNA methylation sites with MZ twinning.
Nikki Hubers   +10 more
wiley   +1 more source

An extra band within the human 9qh+ region that behaves like the surrounding constitutive heterochromatin. [PDF]

open access: bronze, 1994
José Luís Fernández   +4 more
openalex   +1 more source

Functions and Therapeutic Potentials of Long Noncoding RNA in Skeletal Muscle Atrophy and Dystrophy

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 2, April 2025.
ABSTRACT Skeletal muscle is the most abundant tissue in the human body and is responsible for movement, metabolism, energy production and longevity. Muscle atrophy is a frequent complication of several diseases and occurs when protein degradation exceeds protein synthesis.
Yidi Zhang   +4 more
wiley   +1 more source

Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast

open access: yesAging Cell, Volume 24, Issue 4, April 2025.
Extender of chronological lifespan 1 (Ecl1), which inhibits the target of rapamycin complex 1 (TORC1), physically interacts with TORC1 subunits and is necessary for appropriate cellular responses to various stressors, such as starvation, in fission yeast. Several functions of Ecl1 are suppressed by Thr7 phosphorylation when nutrients are abundant.
Hokuto Ohtsuka   +10 more
wiley   +1 more source

Large‐Scale Clustered Transcriptional Silencing Associated With Cellular Senescence

open access: yesAging Cell, Volume 24, Issue 4, April 2025.
Senescence inducing stimuli leads to large‐cluster hypercondensed DNA globules. This architectural phenomenon is associated with geographically clustered transcriptional repression. Such large‐scale clustered silencing of chromosomal segments may drive deep senescence through two possible ways: (1) one or more critical combination of genes, for example
Aditi U. Gurkar   +4 more
wiley   +1 more source

Evaluation of Different Cryoprotectant Combinations in Vitrification and Slow Freezing for Ovarian Tissue Preservation in Domestic Cats

open access: yesReproduction in Domestic Animals, Volume 60, Issue 4, April 2025.
ABSTRACT Over the past decade, increased hunting and habitat disturbance have significantly impacted the endangered population within the Felidae family. Recognising this, it becomes imperative to implement strategies aimed at mitigating this concerning conservation scenario.
Rayane Brandão Ribeiro   +13 more
wiley   +1 more source

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