Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials
Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.With extended lifespans causing population aging, bone aging has become a worldwide issue. Cellular senescence in the bone microenvironment causes bone degeneration and dysfunction. This review summarises targets in cellular senescence and bone aging while detailing potential therapeutic strategies, including novel medicines and innovative biomedical ...
Qiyue Zhu +6 more
wiley +1 more source
Positive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis. [PDF]
Cell Commun SignalKaypee S +7 more
europepmc +1 more source
Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin [PDF]
, 1998 K Hahm +9 more
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Phase Separation in Chromatin Organization and Human Diseases. [PDF]
Int J Mol SciZhai Z, Meng F, Kuang J, Pei D.
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Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy
MedComm – Oncology, Volume 4, Issue 2, June 2025.Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang +4 more
wiley +1 more source
Absence of Pericentromeric Heterochromatin (9qh-) in a Patient with Bilateral Retinoblastoma [PDF]
, 1997 T. A. Sivakumaran +4 more
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Landscape of rare‐allele variants in cultivated and wild soybean genomes
The Plant Genome, Volume 18, Issue 2, June 2025.Abstract Rare‐allele variants are important for crop improvement because they can be linked to important traits. However, genome‐wide distribution and annotation of rare‐allele variants have not been reported. We analyzed sequencing data from 1556 soybean accessions and found 6,533,419 rare‐allele variants in Glycine max and 941,274 in Glycine soja ...
Zhi Liu +9 more
wiley +1 more source
Nucleosome dynamics render heterochromatin accessible in living human cells. [PDF]
Nat CommunPrajapati HK +3 more
europepmc +1 more source
The yeastHMLI silencer defines a heterochromatin domain boundary by directional establishment of silencing [PDF]
, 1999 Xin Bi +3 more
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