Results 231 to 240 of about 133,661 (356)

m6A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post‐Transcriptional Control

Advanced Science, Volume 12, Issue 38, October 13, 2025.
As an m6A reader, hnRNPA2B1 predominantly regulates specific transcripts (e.g., Ep400, Rrs1) that are essential for chromosome organization and remodeling in an m6A‐dependent manner. Furthermore, it is demonstrated to interact with factors involved in mRNA processing and translation. This dual functionality is pivotal for ensuring the proper occurrence
Lisha Yin, Yuting Zhang, Bingqian Zhang, Jin Zhang, Mengneng Xiong, Nan Jiang, Jinxin Xiao, Huihui Gao, Wenjing Xiong, Xiaoli Wang, Fengli Wang, Shuiqiao Yuan   +11 more
wiley   +1 more source

HAND2 invades nucleolar condensates to pioneer lineage-specific cardiac pacemaker gene programs. [PDF]

Nat Commun
Kulkarni K, Quinn G, Dela Rosa J, Goetsch S, Pandit V, Wang L, Sakaguchi A, Sivakumar S, Munshi NV.   +8 more
europepmc   +1 more source

Sequence-directed curvature of repetitiveAluIDNA in constitutive heterochromatin ofArtemia franciscana

, 1989
Roberta Benfante, Nicoletta Landsberger, Grazia Tubiello, Gianfranco Badaracco   +3 more
openalex   +1 more source

Entwined processes in Alzheimer's disease: Brain cellular senescence and Alzheimer's disease pathology

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract Alzheimer's disease (AD) is one of the most common age‐related neurodegenerative diseases with severe progressive dementia. Amyloid beta (Aβ) deposition and phosphorylated tau accumulation are two typical AD pathologies, which could drive senescence in various types of brain cells.
Wen Li, Ying Han, Peichang Wang, Qiao Song   +3 more
wiley   +1 more source

Absence of Pericentromeric Heterochromatin (9qh-) in a Patient with Bilateral Retinoblastoma [PDF]

, 1997
T. A. Sivakumaran, S. Ghose, H. Kumar, Ujwala Singha, Kiran Kucheria   +4 more
openalex   +1 more source

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

BioEssays, Volume 47, Issue 10, October 2025.
Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley   +1 more source

A molecular census to elucidate the demixing mechanism of membraneless organelles. [PDF]

Genome Biol
Ali C, Muzzopappa F, Erdel F.
europepmc   +1 more source

Influence of heterochromatin on chiasma localization and terminalization in maize [PDF]

, 1995
Rosana Torrezan, Maria Suely Pagliarini
openalex   +1 more source

Telomere–metabolism–immunity axis in sarcoma: Immune evasion mechanisms and therapeutic strategies

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
Telomere maintenance mechanisms (telomerase reverse transcriptase and alternative lengthening of telomeres) reprogram metabolism and dampen innate immune sensing in sarcomas. Metabolic rewiring (glutamine addiction, glycolysis and fatty acid oxidation) fosters T‐cell dysfunction and myeloid‐derived suppressor cell accumulation.
Ji‐Yong Sung, June Hyuk Kim
wiley   +1 more source

Peripheral heterochromatin tethering is required for chromatin-based nuclear mechanical response. [PDF]

Nucleic Acids Res
Attar AG, Paturej J, Sarıyer OS, Banigan EJ, Erbaş A.   +4 more
europepmc   +1 more source