Results 231 to 240 of about 124,493 (360)

UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia, He Zhang, Dingqiang Mo, Bo Xie, Hongdou Qiao, Tao Chen, Haoyue Song, Xinxin Xu, Sheng Yang   +8 more
wiley   +1 more source

Constitutive heterochromatin distribution in pig (Sus scrofa) chromosomes [PDF]

, 1998
G.P. Di Meo, A. Perucatti, L. Ferrara, M. Palazzo, D. Matassino, L. Iannuzzi   +5 more
openalex   +1 more source

Mitochondrial complex I deficiency induces Alzheimer's disease–like signatures that are reversible by targeted therapy

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract INTRODUCTION Mitochondrial dysfunction is implicated in Alzheimer's disease (AD), but whether it drives AD‐associated changes is unclear. We assessed transcriptomic alterations in the brains of Ndufs4−/− mice, a model of mitochondrial complex I (mtCI) deficiency, and evaluated the therapeutic effects of the neuroprotective mtCI inhibitor CP2 ...
Huanyao Gao, Kate Jensen, Jarred Nesbitt, Mark Ostroot, Gregory A. Cary, Jesse Wiley, Sergey Trushin, Jens O. Watzlawik, Wolfdieter Springer, Alexander Galkin, Priyanka Baloni, Cory Funk, Eugenia Trushina   +12 more
wiley   +1 more source

Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer

BioEssays, Volume 47, Issue 8, August 2025.
Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley   +1 more source

Dominant Defects in Drosophila Eye Pigmentation Resulting From a Euchromatin-Heterochromatin Fusion Gene [PDF]

, 1998
Yikang S. Rong, Kent G. Golic
openalex   +1 more source

HP1 loses its chromatin clustering and phase separation function across evolution. [PDF]

Nat Commun
Bensaha S, Lewandowska D, Muzzopappa F, Hutin S, Tully MD, Anfossi M, Cammas FM, Normand C, Erdel F.   +8 more
europepmc   +1 more source

The yeastHMLI silencer defines a heterochromatin domain boundary by directional establishment of silencing [PDF]

, 1999
Xin Bi, Miriam Braunstein, Gan-Ju Shei, James R. Broach   +3 more
openalex   +1 more source

Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia. [PDF]

Leukemia
Ding Y, He B, Bogush D, Schramm J, Singh C, Dovat K, Randazzo J, Tukaramrao D, Hengst J, Annageldiyev C, Kudva A, Desai D, Sharma A, Spiegelman VS, Huang S, Viet CT, Dorsam G, Saulnier Scholler G, Broach J, Yue F, Dovat S.   +20 more
europepmc   +1 more source

The Suppression by Protein Synthesis Inhibitors of Sister Chromatid Exchanges Induced by Exogenous Agents in the Euchromatin and Heterochromatin of Chinese Hamster Cells

, 1981
Akira Sono, Kengo Sakaguchi
openalex   +2 more sources

Three-dimensional distribution of centromeric or paracentromeric heterochromatin of chromosomes 1, 7, 15 and 17 in human lymphocyte nuclei studied with light microscopic axial tomography [PDF]

, 1995
Steffen Dietzel, Eva Weilandt, Roland Eils, Christian Münkel, Christoph Cremer, Thomas Cremer   +5 more
openalex   +1 more source