Results 1 to 10 of about 54,545 (273)

Epigenetic memory is governed by an effector recruitment specificity toggle in Heterochromatin Protein 1 [PDF]

Nature Communications
HP1 proteins are essential for establishing and maintaining transcriptionally silent heterochromatin. They dimerize, forming a binding interface to recruit diverse chromatin-associated factors.
Amanda Ames, Melissa Seman, Ajay Larkin, Gulzhan Raiymbek, Ziyuan Chen, Alex Levashkevich, Bokyung Kim, Julie Suzanne Biteen, Kaushik Ragunathan   +8 more
doaj   +4 more sources

Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins [PDF]

ACS Omega, 2021
The heterochromatin protein 1 (HP1) sub-family of CBX chromodomains are responsible for the recognition of histone H3 lysine 9 tri-methyl (H3K9me3)-marked nucleosomal substrates through binding of the N-terminal chromodomain. These HP1 proteins, namely, CBX1 (HP1β), CBX3 (HP1γ), and CBX5 (HP1α), are commonly associated with regions of pericentric ...
Kelsey N. Lamb, Sarah N. Dishman, Jarod M. Waybright, Isabelle A. Engelberg, Justin M. Rectenwald, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Kenneth H. Pearce, Lindsey I. James, Stephen V. Frye   +9 more
doaj   +5 more sources

Characterization of a Novel Heterochromatin Protein 1 Homolog “HP1c” in the Silkworm, Bombyx mori [PDF]

Insects, 2022
Heterochromatin protein 1 plays an important role in chromatin structure and gene expression regulation. Three HP1 genes have been found in Homo sapiens, and five HP1 genes have been reported in Drosophila melanogaster. On the other hand, in Bombyx mori,
Masato Hino, Tsuneyuki Tatsuke, Akihiro Morio, Hiroaki Mon, Jae Man Lee, Akitsu Masuda, Kohei Kakino, Yoshino Tonooka, Takahiro Kusakabe   +8 more
doaj   +2 more sources

Heterochromatin protein 1 beta regulates neural and neural crest development by repressing pluripotency-associated gene pou5f3.2/oct25 in Xenopus. [PDF]

Dev Dyn, 2021
Tien CL, Mohammadparast S, Chang C.
europepmc   +3 more sources

Revealing site-specific molecular features mediating contacts of heterochromatin protein 1 α (HP1α) and the interactions with chromatin and DNA in LLPS environments. [PDF]

Commun Biol
Zhai Z, Soman A, Kuang J, Guo J, Chen Y, Zhao L, Prasanna C, Putri DA, Glukhov GS, Chng CP, Huang C, Nordenskiöld L, Xue K, Shi X.   +13 more
europepmc   +3 more sources

TORC2 inactivation promotes heterochromatin formation in rDNA and prolongs viability of quiescent fission yeast cells [PDF]

Communications Biology
A large amount of the energy produced by glucose is consumed in the biogenesis of ribosomes, the cellular machinery for protein synthesis. Recent studies suggest that a low-calorie diet and the suppression of ribosome biogenesis can extend lifespan ...
Hayato Hirai, Kunihiro Ohta
doaj   +2 more sources

Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture. [PDF]

Nucleic Acids Res
Lou J, Deng Q, Zhang X, Bell CC, Das AB, Bediaga NG, Zlatic CO, Johanson TM, Allan RS, Griffin MDW, Paradkar P, Harvey KF, Dawson MA, Hinde E.   +13 more
europepmc   +2 more sources

LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) partially inhibits the transcriptional activation of FT by MYB73 and regulates flowering in Arabidopsis. [PDF]

Plant J
Chae J, Han SJ, Karthik S, Kim HJ, Kim JH, Yun HR, Chung YS, Sung S, Heo JB.   +8 more
europepmc   +3 more sources

Recurrent Amplification of the Heterochromatin Protein 1 (HP1) Gene Family across Diptera. [PDF]

Mol Biol Evol, 2018
Helleu Q, Levine MT.
europepmc   +3 more sources

Correction to "Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging". [PDF]

MedComm (2020)
F Wang, L Zhou, Y Zhong
europepmc   +3 more sources