Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha. [PDF]
PLoS ONE, 2013 Heterochromatin protein 1 (HP1) is an essential heterochromatin-associated protein typically involved in the epigenetic regulation of gene silencing. However, recent reports have demonstrated that HP1 can also activate gene expression in certain contexts
Patima Sdek +5 more
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Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins [PDF]
ACS Omega, 2021 The heterochromatin protein 1 (HP1) sub-family of CBX chromodomains are responsible for the recognition of histone H3 lysine 9 tri-methyl (H3K9me3)-marked nucleosomal substrates through binding of the N-terminal chromodomain. These HP1 proteins, namely, CBX1 (HP1β), CBX3 (HP1γ), and CBX5 (HP1α), are commonly associated with regions of pericentric ...
Kelsey N. Lamb +9 more
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The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis [PDF]
Nature Communications, 2022 This study reports reduced expression of the chromatin and splicing regulator HP1γ in inflammatory bowel disease (IBD) and shows that HP1γ protects against pervasive RNA splicing leading to toxic mRNA products detected in IBD, like progerin.
Jorge Mata-Garrido +17 more
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Heterochromatin protein 1 (HP1): interactions with itself and chromatin components. [PDF]
Biophys Rev, 2020 Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the dissimilarities coded in protein sequence which confers different biophysical and biochemical properties to individual ...
Kumar A, Kono H.
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Characterization of a Novel Heterochromatin Protein 1 Homolog “HP1c” in the Silkworm, Bombyx mori [PDF]
Insects, 2022 Heterochromatin protein 1 plays an important role in chromatin structure and gene expression regulation. Three HP1 genes have been found in Homo sapiens, and five HP1 genes have been reported in Drosophila melanogaster. On the other hand, in Bombyx mori,
Masato Hino +8 more
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Epigenetic memory is governed by an effector recruitment specificity toggle in Heterochromatin Protein 1 [PDF]
Nature CommunicationsHP1 proteins are essential for establishing and maintaining transcriptionally silent heterochromatin. They dimerize, forming a binding interface to recruit diverse chromatin-associated factors.
Amanda Ames +8 more
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TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells. [PDF]
Oncogene, 2019 Crawford NT +5 more
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The Growth, Pathogenesis, and Secondary Metabolism of <i>Fusarium verticillioides</i> Are Epigenetically Modulated by Putative Heterochromatin Protein 1 (FvHP1). [PDF]
J Fungi (Basel)Jacquat AG +7 more
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Heterochromatin protein 1 (HP1) of Schistosoma mansoni: non-canonical chromatin landscape and oviposition effects. [PDF]
Mem Inst Oswaldo Cruzda Trindade NS +7 more
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Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture. [PDF]
Nucleic Acids ResLou J +13 more
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