Results 1 to 10 of about 603,291 (199)

Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha. [PDF]

PLoS One, 2013
Heterochromatin protein 1 (HP1) is an essential heterochromatin-associated protein typically involved in the epigenetic regulation of gene silencing. However, recent reports have demonstrated that HP1 can also activate gene expression in certain contexts
Sdek P, Oyama K, Angelis E, Chan SS, Schenke-Layland K, MacLellan WR.   +5 more
europepmc   +4 more sources

Characterization of a Novel Heterochromatin Protein 1 Homolog "HP1c" in the Silkworm, Bombyx mori. [PDF]

Insects, 2022
Heterochromatin protein 1 plays an important role in chromatin structure and gene expression regulation. Three HP1 genes have been found in Homo sapiens, and five HP1 genes have been reported in Drosophila melanogaster. On the other hand, in Bombyx mori,
Hino M, Tatsuke T, Morio A, Mon H, Lee JM, Masuda A, Kakino K, Tonooka Y, Kusakabe T.   +8 more
europepmc   +2 more sources

The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis. [PDF]

Nat Commun, 2022
This study reports reduced expression of the chromatin and splicing regulator HP1γ in inflammatory bowel disease (IBD) and shows that HP1γ protects against pervasive RNA splicing leading to toxic mRNA products detected in IBD, like progerin.
Mata-Garrido J, Xiang Y, Chang-Marchand Y, Reisacher C, Ageron E, Guerrera IC, Casafont I, Bruneau A, Cherbuy C, Treton X, Dumay A, Ogier-Denis E, Batsché E, Costallat M, Revêchon G, Eriksson M, Muchardt C, Arbibe L.   +17 more
europepmc   +2 more sources

Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins. [PDF]

ACS Omega, 2022
Lamb KN, Dishman SN, Waybright JM, Engelberg IA, Rectenwald JM, Norris-Drouin JL, Cholensky SH, Pearce KH, James LI, Frye SV.   +9 more
europepmc   +2 more sources

Heterochromatin protein 1 (HP1): interactions with itself and chromatin components. [PDF]

Biophys Rev, 2020
Kumar A, Kono H.
europepmc   +3 more sources

Epigenetic memory is governed by an effector recruitment specificity toggle in Heterochromatin Protein 1. [PDF]

Nat Commun
HP1 proteins are essential for establishing and maintaining transcriptionally silent heterochromatin. They dimerize, forming a binding interface to recruit diverse chromatin-associated factors.
Ames A, Seman M, Larkin A, Raiymbek G, Chen Z, Levashkevich A, Kim B, Biteen JS, Ragunathan K.   +8 more
europepmc   +2 more sources

TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells. [PDF]

Oncogene, 2019
Crawford NT, McIntyre AJ, McCormick A, D'Costa ZC, Buckley NE, Mullan PB.   +5 more
europepmc   +3 more sources

Heterochromatin protein 1 (HP1) of Schistosoma mansoni: non-canonical chromatin landscape and oviposition effects. [PDF]

Mem Inst Oswaldo Cruz
da Trindade NS, Valentini MB, Rognon A, Mendes TMF, Gomes MS, Allegretti SM, Grunau C, Cabral FJ.   +7 more
europepmc   +2 more sources

Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture. [PDF]

Nucleic Acids Res
Lou J, Deng Q, Zhang X, Bell CC, Das AB, Bediaga NG, Zlatic CO, Johanson TM, Allan RS, Griffin MDW, Paradkar P, Harvey KF, Dawson MA, Hinde E.   +13 more
europepmc   +2 more sources

Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1. [PDF]

J Biol Chem, 2017
Liu Y, Qin S, Lei M, Tempel W, Zhang Y, Loppnau P, Li Y, Min J.   +7 more
europepmc   +2 more sources