Epigenetic memory is governed by an effector recruitment specificity toggle in Heterochromatin Protein 1 [PDF]
Nature CommunicationsHP1 proteins are essential for establishing and maintaining transcriptionally silent heterochromatin. They dimerize, forming a binding interface to recruit diverse chromatin-associated factors.
Amanda Ames +8 more
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Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins [PDF]
ACS Omega, 2021 The heterochromatin protein 1 (HP1) sub-family of CBX chromodomains are responsible for the recognition of histone H3 lysine 9 tri-methyl (H3K9me3)-marked nucleosomal substrates through binding of the N-terminal chromodomain. These HP1 proteins, namely, CBX1 (HP1β), CBX3 (HP1γ), and CBX5 (HP1α), are commonly associated with regions of pericentric ...
Kelsey N. Lamb +9 more
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Heterochromatin protein 1 (HP1): interactions with itself and chromatin components. [PDF]
Biophys Rev, 2020 Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the dissimilarities coded in protein sequence which confers different biophysical and biochemical properties to individual ...
Kumar A, Kumar A, Kono H.
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Characterization of a Novel Heterochromatin Protein 1 Homolog “HP1c” in the Silkworm, Bombyx mori [PDF]
Insects, 2022 Heterochromatin protein 1 plays an important role in chromatin structure and gene expression regulation. Three HP1 genes have been found in Homo sapiens, and five HP1 genes have been reported in Drosophila melanogaster. On the other hand, in Bombyx mori,
Masato Hino +8 more
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An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions [PDF]
Epigenetics, 2017 The presence of H3K9me3 and heterochromatin protein 1 (HP1) are hallmarks of heterochromatin conserved in eukaryotes. The spreading and maintenance of H3K9me3 is effected by the functional interplay between the H3K9me3-specific histone methyltransferase ...
Helena Raurell-Vila +9 more
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Heterochromatin protein 1 beta regulates neural and neural crest development by repressing pluripotency-associated gene pou5f3.2/oct25 in Xenopus. [PDF]
Dev Dyn, 2021 Tien CL, Mohammadparast S, Chang C.
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TORC2 inactivation promotes heterochromatin formation in rDNA and prolongs viability of quiescent fission yeast cells [PDF]
Communications BiologyA large amount of the energy produced by glucose is consumed in the biogenesis of ribosomes, the cellular machinery for protein synthesis. Recent studies suggest that a low-calorie diet and the suppression of ribosome biogenesis can extend lifespan ...
Hayato Hirai, Kunihiro Ohta
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Revealing site-specific molecular features mediating contacts of heterochromatin protein 1 α (HP1α) and the interactions with chromatin and DNA in LLPS environments. [PDF]
Commun BiolZhai Z +13 more
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Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture. [PDF]
Nucleic Acids ResLou J +13 more
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Recurrent Amplification of the Heterochromatin Protein 1 (HP1) Gene Family across Diptera. [PDF]
Mol Biol Evol, 2018 Helleu Q, Levine MT.
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