Results 1 to 10 of about 612,093 (259)
Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha. [PDF]
PLoS ONE, 2013 Heterochromatin protein 1 (HP1) is an essential heterochromatin-associated protein typically involved in the epigenetic regulation of gene silencing. However, recent reports have demonstrated that HP1 can also activate gene expression in certain contexts
Patima Sdek +5 more
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Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins [PDF]
ACS Omega, 2021 The heterochromatin protein 1 (HP1) sub-family of CBX chromodomains are responsible for the recognition of histone H3 lysine 9 tri-methyl (H3K9me3)-marked nucleosomal substrates through binding of the N-terminal chromodomain. These HP1 proteins, namely, CBX1 (HP1β), CBX3 (HP1γ), and CBX5 (HP1α), are commonly associated with regions of pericentric ...
Kelsey N. Lamb +9 more
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Heterochromatin protein 1 (HP1): interactions with itself and chromatin components. [PDF]
Biophys Rev, 2020 Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the dissimilarities coded in protein sequence which confers different biophysical and biochemical properties to individual ...
Kumar A, Kono H.
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Heterochromatin Protein 1: A Multiplayer in Cancer Progression. [PDF]
Cancers (Basel), 2022 Dysregulation of epigenetic mechanisms as well as genomic mutations contribute to the initiation and progression of cancer. In addition to histone code writers, including histone lysine methyltransferase (KMT), and histone code erasers, including histone lysine demethylase (KDM), histone code reader proteins such as HP1 are associated with abnormal ...
Jeon YH +7 more
europepmc +4 more sources
Conservation of Heterochromatin Protein 1 Function [PDF]
Molecular and Cellular Biology, 2000 Heterochromatin represents a cytologically visible state of heritable gene repression. In the yeast, Schizosaccharomyces pombe, the swi6 gene encodes a heterochromatin protein 1 (HP1)-like chromodomain protein that localizes to heterochromatin domains, including the centromeres, telomeres, and the donor mating-type loci, and is involved in silencing at
Guozheng Wang +6 more
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Characterization of a Novel Heterochromatin Protein 1 Homolog “HP1c” in the Silkworm, Bombyx mori [PDF]
Insects, 2022 Heterochromatin protein 1 plays an important role in chromatin structure and gene expression regulation. Three HP1 genes have been found in Homo sapiens, and five HP1 genes have been reported in Drosophila melanogaster. On the other hand, in Bombyx mori,
Masato Hino +8 more
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The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis [PDF]
Nature Communications, 2022 This study reports reduced expression of the chromatin and splicing regulator HP1γ in inflammatory bowel disease (IBD) and shows that HP1γ protects against pervasive RNA splicing leading to toxic mRNA products detected in IBD, like progerin.
Jorge Mata-Garrido +17 more
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Dynamic associations of heterochromatin protein 1 with the nuclear envelope [PDF]
The EMBO Journal, 2000 To study the dynamics of mammalian HP1 proteins we have microinjected recombinant forms of mHP1alpha, M31 and M32 into the cytoplasm of living cells. As could be expected from previous studies, the three fusion proteins were efficiently transported into the nucleus and targeted specific chromatin areas.
Niki Kourmouli
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Heterochromatin Protein 1 Binds to Nucleosomes and DNA in Vitro [PDF]
Journal of Biological Chemistry, 2000 Heterochromatin protein 1 (HP1) is a nonhistone chromosomal protein primarily associated with the pericentric heterochromatin and telomeres in Drosophila. The molecular mechanism by which HP1 specifically recognizes and binds to chromatin is unknown. The purpose of this study was to test whether HP1 can bind directly to nucleosomes.
Tao Zhao +3 more
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Comparison of three heterochromatin protein 1 homologs in Drosophila [PDF]
Journal of Cell Science, 2019 ABSTRACT Heterochromatin protein 1 (HP1) is an epigenetic regulator of chromatin structure and genome function in eukaryotes. Despite shared features, most eukaryotes have a minimum of three HP1 homologs with differential localization patterns and functions.
Dong Hoon Lee +3 more
openalex +4 more sources