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RID is required for both repeat-induced point mutation and nucleation of a novel transitional heterochromatic state for euchromatic repeats. [PDF]
He Z+11 more
europepmc +1 more source
Unveiling the dynamic drivers: phase separation's pivotal role in stem cell biology and therapeutic potential. [PDF]
Lin P+6 more
europepmc +1 more source
Emerging roles for the nucleolus in development and stem cells.
Leeke BJ, Staffhorst I, Percharde M.
europepmc +1 more source
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Function of heterochromatin protein 1 during DNA repair
Protoplasma, 2017This review focuses on the function of heterochromatin protein HP1 in response to DNA damage. We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1α, HP1β, and HP1γ) are the main components of constitutive heterochromatin, and HP1α and HP1β in particular are responsible for ...
E. Bártová+6 more
semanticscholar +4 more sources
Analysis of the heterochromatin protein 1 (HP1) interactome in Drosophila.
Journal of Proteomics, 2014Heterochromatin protein 1 (HP1) was first described in Drosophila melanogaster as a heterochromatin associated protein required for epigenetic gene silencing. Most eukaryotes have at least three HP1 homologs that play differential roles in heterochromatin and euchromatin.
Hyun-Wook Ryu+5 more
semanticscholar +4 more sources
Heterochromatin protein 1 expression is reduced in human thyroid malignancy [PDF]
Owing to the loss of heterochromatin integrity that occurs during thyroid tumorigenesis, the expression of Heterochromatin Protein 1 isoforms HP1α and HP1β was assessed by immunohistochemistry in 189 thyroid tumors and non-neoplastic tissues. Expression of HP1β was significantly decreased in all thyroid lesions, except in follicular adenomas, when ...
M. Tretiakova+6 more
semanticscholar +3 more sources
The Heterochronic Gene Oryza sativa LIKE HETEROCHROMATIN PROTEIN 1 Modulates miR156b/c/i/e Levels.
Journal of Integrative Plant Biology, 2020The juvenile-to-adult transition in plants involves changes in vegetative growth and plant architecture; the timing of this transition has important implications for agriculture.
Yongtao Cui+13 more
semanticscholar +1 more source
Heterochromatin protein 1 binds transgene arrays
Chromosoma, 1998Heterochromatin protein 1 (HP1) of Drosophila and its homologs in vertebrates are key components of constitutive heterochromatin. Here we provide cytological evidence for the presence of heterochromatin within a euchromatic chromosome arm by immunolocalization of HP1 to the site of a silenced transgene repeat array.
FANTI, Laura+4 more
openaire +4 more sources