Results 31 to 40 of about 28,367 (257)

A review: Biologically active 3,4-heterocycle-fused coumarins

, 2021
© 2020 Elsevier Masson SASThe combination of heterocycles offers a new opportunity to create novel multicyclic compounds having improved biological activity.
Youseftabar-Miri, Leila, Tüylü Küçükkilinç, Tuba, Sharifzadeh, Mohammad, Salehian, Fatemeh, Foroumadi, Alireza, Khoobi, Mehdi, Abbas Bukhari, Syed Nasir, Nadri, Hamid, Jalili-Baleh, Leili   +8 more
core   +1 more source

Inhibition studies of Brucella suis β-carbonic anhydrases with a series of 4-substituted pyridine-3-sulphonamides

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The two β-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Brucella suis, BsuCA1 and BsuCA2, were investigated for their inhibition profile with a series of pyridine-3-sulphonamide derivatives incorporating 4-hetaryl moieties.
Simona Maria Monti, Angela Meccariello, Mariangela Ceruso, Krzysztof Szafrański, Jarosław Sławiński, Claudiu T. Supuran   +5 more
doaj   +1 more source

4-Chloro-6-ethoxy-2-(methylthio)pyrimidine

Molbank, 2016
4,6-Dichloro-2-(methylthio)pyrimidine (3) reacts with EtONa in EtOH, at ca. 20 °C, for 2 h, to give exclusively 4-chloro-6-ethoxy-2-(methylthio)pyrimidine (5) in 89% yield. The latter is presented as a useful multifunctionalised pyrimidine scaffold.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

Frontiers in Chemistry, 2018
The comprehensive review contains the analysis of literature data concerning reactions of heterocyclization of aminoazoles and demonstrates the application of these types of transformations in diversity-oriented synthesis.
Maryna V. Murlykina, Alisa D. Morozova, Ievgen M. Zviagin, Yana I. Sakhno, Sergey M. Desenko, Sergey M. Desenko, Valentyn A. Chebanov, Valentyn A. Chebanov   +7 more
doaj   +1 more source

Transformation of (allo)securinine to (allo)norsecurinine via a molecular editing strategy

Frontiers in Chemistry
Securinega alkaloids have intrigued chemists since the isolation of securinine in 1956. This family of natural products comprises a securinane subfamily with a piperidine substructure and norsecurinane alkaloids featuring a pyrrolidine core.
Seoyoung Kim, Hee-Seung Lee, Sunkyu Han
doaj   +1 more source

Synthetic strategy toward furyl- and benzofuryl-containing building blocks for organic materials

Chimica Techno Acta, 2022
A synthetic approach to furyl- and benzofuryl-containing building blocks utilizing easily accessible substrates is reported. Cascade acid-catalyzed reactions of 2-methylfuran with α,β-unsaturated carbonyl compounds or salicyl alcohols followed by ...
Diana A. Eshmemet’eva, Danil K. Vshivkov, Yury A. Vasev, Danil A. Myasnikov   +3 more
doaj   +1 more source

Constrained Dipeptide Surrogates: 5- and 7-Hydroxy Indolizidin-2-one Amino Acid Synthesis from Iodolactonization of Dehydro-2,8-diamino Azelates

Molecules, 2021
The constrained dipeptide surrogates 5- and 7-hydroxy indolizidin-2-one N-(Boc)amino acids have been synthesized from L-serine as a chiral educt. A linear precursor ∆4-unsaturated (2S,8S)-2,8-bis[N-(Boc)amino]azelic acid was prepared in five steps from L-
Ramakotaiah Mulamreddy, William D. Lubell   +1 more
doaj   +1 more source

(1R*,2R*,5R*,6S*)-6-Bromo-9-oxabicyclo[3.3.1]nonan-2-ol

IUCrData
Both six-membered rings in the title bicyclo[3.3.1] system, C8H13BrO2, adopt a chair conformation. Hydrogen bonds from the hydroxy group to the ether bridge connect the molecules into zigzag chains: single-enantiomer chains propagating along the b-axis ...
Lea Simon, Heiner Detert, Dieter Schollmeyer   +2 more
doaj   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

G^C Quartet  A DNA-Inspired Janus-GC Heterocycle: Synthesis, Structural Analysis, and Self-Organization

, 2016
G^C Quartet  A DNA-Inspired Janus-GC Heterocycle: Synthesis, Structural Analysis, and Self ...
Brian O. Patrick (155965), Ali Asadi (252077), David M. Perrin (1795915)   +2 more
core   +3 more sources