Results 51 to 60 of about 27,695 (265)

Derivatisable cyanobactin analogues : a semisynthetic approach [PDF]

, 2015
This work was supported by the European Research Council (339367), UK Biotechnology and Biological Sciences Research Council (K015508/1) and the Wellcome Trust (Triple TOF 5600 mass spectrometer (094476), the MALDI TOF-TOF Analyser (079272AIA), 700 NMR ...
Naismith, Jim, Oueis, Emilia, Naismith, James H, Greg Mann, Adamson, Catherine S, Westwood, Nicholas James, Adamson, Catherine, Emilia Oueis, Migaud, Marie, Nicholas J. Westwood, James H. Naismith, Westwood, Nicholas J, Catherine Adamson, Mann, Greg, Ludewig, Hannes, Redpath, Philip, Hannes Ludewig, Marie Migaud, Philip Redpath   +18 more
core   +1 more source

Hyperpolarization of [1‐13C]Ketoisocaproate‐d2 by Reversible Exchange with Parahydrogen Enables Profiling of Branched‐Chain‐Amino‐Acid Metabolism in Cellulo and in Vivo

Advanced Science, EarlyView.
We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen, Philipp R. Groß, Paul M. Schmidt, Henri de Maissin, Asitan Rittinger, Robert Willing, Adriana Sacristán‐Martín, Lisa Heß, Jule Koch, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Jan‐Bernd Hövener, André F. Martins, Max von Delius, Thomas Reinheckel, Andreas B. Schmidt   +18 more
wiley   +1 more source

Syntheses and medicinal chemistry of spiro heterocyclic steroids

Beilstein Journal of Organic Chemistry
There is compelling evidence that incorporating a heterocyclic moiety into a steroid can alter its pharmacological and pharmacokinetic properties, driving intense interest in the synthesis of such hybrids among research groups. In this review, we present
Laura L. Romero-Hernández, Ana Isabel Ahuja-Casarín, Penélope Merino-Montiel, Sara Montiel-Smith, José Luis Vega-Báez, Jesús Sandoval-Ramírez   +5 more
doaj   +1 more source

Discovery of 4,5-Dihydro-1H-thieno[2′,3′:2,3]thiepino [4,5-c]pyrazole-3-carboxamide Derivatives as the Potential Epidermal Growth Factor Receptors for Tyrosine Kinase Inhibitors

Molecules, 2018
The epidermal growth factor receptors (EGFRs), in which overexpression (known as upregulation) or overactivity have been associated with a number of cancers, has become an attractive molecular target for the treatment of selective cancers. We report here
Jia Ke, Qi Lu, Xin Wang, Rui Sun, Zhe Jin, Xiaoyi Zhan, Jianshu Hu, David Chi-cheong Wan, Chun Hu   +8 more
doaj   +1 more source

Transfer learning for Heterocycle Synthesis Prediction [PDF]

Heterocycles are important scaffolds in medicinal chemistry that can be used to modulate the binding mode as well as pharmacokinetic properties of drugs.
Dominik, Miketa, Victor S., Perez, Fernanda, Duarte, Paul E., Brennan, Joshua W., Sin, Liam, Wilbraham, Ewa , Wieczorek, Matthew T. O., Holland, Anthony, Bradley   +8 more
core   +2 more sources

Calcium‐Mechanochemistry Enabled Ketone Synthesis From Organic Iodides and Carboxylic Acids

Advanced Science, EarlyView.
Mechanochemically generated organocalcium species display unusual chemoselectivity toward carboxylates, enabling direct ketone synthesis without overaddition. Ball milling activates commercial calcium metal under ambient, solvent‐minimized conditions, providing a broad substrate scope, high functional‐group tolerance, and a practical one‐step ...
Mengyao Pei, Zekun Yang, Xueyan Yang, Yufang Yang, Yangyang Shen, Jiemin Wang, Peile Ma, Zezhu Li, Xiaoliang Zheng, Xiaofeng Wei   +9 more
wiley   +1 more source

Convenient Synthesis of Thiohydantoins, Imidazole-2-thiones and Imidazo[2,1-b]thiazol-4-iums from Polymer-Supported α-Acylamino Ketones

Molecules, 2018
The preparation of 5-methylene-thiohydantoins using solid-phase synthesis is reported in this paper. After sulfonylation of immobilized Ser (t-Bu)-OH with 4-nitrobenzenesulfonyl chloride followed by alkylation with various bromoketones, the 4-Nos group ...
Petra Králová, Michal Maloň, Hiroyuki Koshino, Miroslav Soural   +3 more
doaj   +1 more source

Palladium-catalysed heterocycle synthesis [PDF]

, 2012
Chapter 1 is a literature review of selected palladium-catalysed aryl C-N and C-S bond forming reactions. The application of these reactions to the synthesis of heterocycles is also discussed.
Sadig, Jessie E.R.
core   +1 more source

Pd‐Catalyzed Asymmetric Dearomative Heck/Tsuji‐Trost Difunctionalization of Naphthalenes

Advanced Science, EarlyView.
We have developed a palladium‐catalyzed asymmetric dearomative Heck/Tsuji‐Trost 1,4‐difunctionalization reaction of naphthalenes, affording 4‐aminospirocyclohexene oxindole products bearing two remote chiral centers. Through the effect of the newly designed chiral sulfinamide phosphine ligand with large steric hindrance, side reactions are inhibited ...
Long‐Ling Ma, Bing Xu, Junliang Zhang, Zhan‐Ming Zhang   +3 more
wiley   +1 more source

Iodine-Catalyzed Diversity-Oriented Synthesis of 3,4-Heterocycle-Fused Coumarins from 4‑Aminocoumarins and Aurones in Different Solvent

An unprecedented protocol has been developed for the synthesis of 3,4-heterocycle-fused coumarins from 4-aminocoumarins and aurones through iodine-catalyzed cascade reactions.
Lin Ma (23007), Changhui Yang (18369449), Suyue Duan (18369452), Xianfu Shen (4817457), Zhen Jiang (846105), Dan Yue (695973), Xuequan Wang (697301), Chahui Du (18369446)   +7 more
core   +1 more source